JP2009513660A - 肺動脈性高血圧の治療用併用療法におけるファスジル - Google Patents
肺動脈性高血圧の治療用併用療法におけるファスジル Download PDFInfo
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- JP2009513660A JP2009513660A JP2008537949A JP2008537949A JP2009513660A JP 2009513660 A JP2009513660 A JP 2009513660A JP 2008537949 A JP2008537949 A JP 2008537949A JP 2008537949 A JP2008537949 A JP 2008537949A JP 2009513660 A JP2009513660 A JP 2009513660A
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- Prior art keywords
- fasudil
- therapeutic combination
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- sarpogrelate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
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- A61P9/12—Antihypertensives
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73027305P | 2005-10-26 | 2005-10-26 | |
| PCT/US2006/041830 WO2007050783A2 (en) | 2005-10-26 | 2006-10-25 | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009513660A true JP2009513660A (ja) | 2009-04-02 |
| JP2009513660A5 JP2009513660A5 (enExample) | 2009-08-20 |
Family
ID=37814479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537949A Pending JP2009513660A (ja) | 2005-10-26 | 2006-10-25 | 肺動脈性高血圧の治療用併用療法におけるファスジル |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7893050B2 (enExample) |
| EP (2) | EP1951253A2 (enExample) |
| JP (1) | JP2009513660A (enExample) |
| AT (1) | ATE551059T1 (enExample) |
| WO (1) | WO2007050783A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011149012A1 (ja) * | 2010-05-27 | 2011-12-01 | 参天製薬株式会社 | イソキノリンスルホニル誘導体を有効成分として含有する網脈絡膜変性疾患の予防または治療剤、網脈絡膜変性疾患の予防または治療方法、イソキノリンスルホニル誘導体またはその医薬的に許容される塩、ならびにその使用 |
| JP2013501032A (ja) * | 2009-08-07 | 2013-01-10 | サイファーム ソシエテ ア レスポンサビリテ リミテ | 嚢胞性線維症の治療のための組成物 |
| JP2014505082A (ja) * | 2011-02-07 | 2014-02-27 | サイファーム ソシエテ ア レスポンサビリテ リミテ | 嚢胞性線維症の処置のための新規組成物 |
| WO2017170981A1 (ja) * | 2016-04-01 | 2017-10-05 | 国立大学法人京都大学 | Fgfr3病の予防または治療剤 |
| JP2020513028A (ja) * | 2017-04-11 | 2020-04-30 | セバ・サンテ・アニマル | 哺乳動物における心疾患の処置方法 |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7470787B2 (en) * | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| WO2007008942A2 (en) * | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Phenylamino-acetic acid [1-(pyridin-4-yl)-methylidene]-hydrazide derivatives and related compounds as modulators of g protein-coupled receptor kinases for the treatment of eye diseases |
| ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
| JP5235887B2 (ja) | 2006-09-20 | 2013-07-10 | アエリー ファーマシューティカルズ インコーポレイテッド | Rhoキナーゼ阻害剤 |
| WO2008049000A2 (en) * | 2006-10-18 | 2008-04-24 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010103040A1 (en) * | 2009-03-10 | 2010-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | 5'-adenosine monophosphate-activated protein kinase (ampk) activators for treating pulmonary hypertension |
| WO2010126626A2 (en) | 2009-05-01 | 2010-11-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| US8871781B2 (en) | 2011-11-30 | 2014-10-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating a subject for a lymphatic malformation |
| PT3811943T (pt) | 2013-03-15 | 2023-03-15 | Aerie Pharmaceuticals Inc | Composto para uso no tratamento de distúrbios oculares |
| EP2970149B1 (en) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Microcrystalline diketopiperazine compositions and methods |
| CN105451716A (zh) | 2013-07-18 | 2016-03-30 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
| US20150044288A1 (en) | 2013-07-31 | 2015-02-12 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| KR102276424B1 (ko) | 2014-10-06 | 2021-07-12 | 삼성전자주식회사 | 로-키나제 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| KR20160049435A (ko) | 2014-10-27 | 2016-05-09 | 삼성전자주식회사 | Atm 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| EP3112466A1 (en) | 2015-07-01 | 2017-01-04 | Samsung Electronics Co., Ltd. | Composition for reducing cellular senescence level including activity inhibitor inhibiting dcun1d3 activity or expression inhibitor inhibiting expression of dcun1d3-encoding gene and use thereof |
| US12048761B2 (en) * | 2015-10-13 | 2024-07-30 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion |
| WO2017086941A1 (en) | 2015-11-17 | 2017-05-26 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US11389441B2 (en) | 2016-08-31 | 2022-07-19 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| MA46749A (fr) | 2016-11-08 | 2019-09-18 | Reata Pharmaceuticals Inc | Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier |
| CA3057872A1 (en) | 2017-03-31 | 2018-10-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US20190125756A1 (en) * | 2017-11-01 | 2019-05-02 | Cipla Limited | Method of treating hypertension |
| US20210338699A1 (en) * | 2018-08-30 | 2021-11-04 | The Trustees Of Indiana University | Materials and methods for suppressing and/or treating cancer and/or cancer treatment induced cardiac toxicity |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| JP2022532431A (ja) | 2019-05-16 | 2022-07-14 | エアロベイト セラピューティクス, インコーポレイテッド | イマチニブ製剤、その製造および使用 |
| US20240325390A1 (en) * | 2020-11-23 | 2024-10-03 | Aerovate Therapeutics, Inc. | Imatinib formulations, manufacture, and uses thereof |
| WO2022245719A1 (en) * | 2021-05-19 | 2022-11-24 | Woolsey Pharmaceuticals, Inc. | Methods of treating depression and anxiety |
| MX2023013536A (es) * | 2021-05-19 | 2023-11-27 | Woolsey Pharmaceuticals Inc | Metodos para tratar la depresion y la ansiedad. |
| EP4429667A4 (en) * | 2021-11-12 | 2025-09-17 | Woolsey Pharmaceuticals Inc | METHOD OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND ASSOCIATED DOSAGE REGIMEN |
| EP4479058A1 (en) | 2022-02-17 | 2024-12-25 | Woolsey Pharmaceuticals, Inc. | Oral formulations of fasudil with ion exchange resin |
| JP2025506686A (ja) | 2022-02-17 | 2025-03-13 | ウールジー・ファーマシューティカルズ・インコーポレイテッド | ファスジルの味マスキング経口製剤 |
| WO2024238454A2 (en) * | 2023-05-12 | 2024-11-21 | The Texas A&M University System | Compositions and methods for the diagnosis and treatment of microvasculature dysfunction and related diseases |
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| US110553A (en) * | 1870-12-27 | Improvement in preventing incrustation of steam-boilers | ||
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| BE578515A (enExample) * | 1958-05-07 | |||
| US3047591A (en) * | 1959-08-31 | 1962-07-31 | British Drug Houses Ltd | Preparation of 17alpha-acyloxy-6alpha-methyl-16-methylenepregn-4-ene-3,20-diones |
| DE1265758B (de) | 1960-05-25 | 1968-04-11 | Guidotti & C Spa Labor | Verfahren zur Herstellung von o-(beta-Dialkylaminoaethoxy)-phenylketonen und deren Saeureadditionssalzen und quartaeren Salzen |
| SE300218B (enExample) | 1960-11-08 | 1968-04-22 | Recip Ab | |
| DE1154810B (de) | 1961-04-01 | 1963-09-26 | Knoll Ag | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
| US3262977A (en) | 1962-03-10 | 1966-07-26 | Chinoin Gyogyszer Es Vegyeszet | N-aralkyl-1, 1-diphenyl-propylamine derivatives |
| BR6464291D0 (pt) | 1963-11-26 | 1973-07-26 | Merrell Inc Richardson | Processo para preparar o novo composto quimico 1-1-di cloro-hexil-2-(2-piperidil)-etina |
| NL137318C (enExample) * | 1964-06-09 | |||
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-
2006
- 2006-10-25 AT AT09007232T patent/ATE551059T1/de active
- 2006-10-25 EP EP06826765A patent/EP1951253A2/en not_active Withdrawn
- 2006-10-25 US US11/588,185 patent/US7893050B2/en not_active Expired - Fee Related
- 2006-10-25 WO PCT/US2006/041830 patent/WO2007050783A2/en not_active Ceased
- 2006-10-25 EP EP09007232A patent/EP2111863B1/en not_active Not-in-force
- 2006-10-25 JP JP2008537949A patent/JP2009513660A/ja active Pending
-
2011
- 2011-01-13 US US13/005,954 patent/US20110171139A1/en not_active Abandoned
-
2012
- 2012-09-12 US US13/611,849 patent/US8476259B2/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013501032A (ja) * | 2009-08-07 | 2013-01-10 | サイファーム ソシエテ ア レスポンサビリテ リミテ | 嚢胞性線維症の治療のための組成物 |
| WO2011149012A1 (ja) * | 2010-05-27 | 2011-12-01 | 参天製薬株式会社 | イソキノリンスルホニル誘導体を有効成分として含有する網脈絡膜変性疾患の予防または治療剤、網脈絡膜変性疾患の予防または治療方法、イソキノリンスルホニル誘導体またはその医薬的に許容される塩、ならびにその使用 |
| JP2014505082A (ja) * | 2011-02-07 | 2014-02-27 | サイファーム ソシエテ ア レスポンサビリテ リミテ | 嚢胞性線維症の処置のための新規組成物 |
| WO2017170981A1 (ja) * | 2016-04-01 | 2017-10-05 | 国立大学法人京都大学 | Fgfr3病の予防または治療剤 |
| JP2020513028A (ja) * | 2017-04-11 | 2020-04-30 | セバ・サンテ・アニマル | 哺乳動物における心疾患の処置方法 |
| JP7148545B2 (ja) | 2017-04-11 | 2022-10-05 | セバ・サンテ・アニマル | 哺乳動物における心疾患の処置方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130005711A1 (en) | 2013-01-03 |
| US20110171139A1 (en) | 2011-07-14 |
| EP2111863A1 (en) | 2009-10-28 |
| WO2007050783A2 (en) | 2007-05-03 |
| US8476259B2 (en) | 2013-07-02 |
| EP1951253A2 (en) | 2008-08-06 |
| US20070111983A1 (en) | 2007-05-17 |
| EP2111863B1 (en) | 2012-03-28 |
| WO2007050783A3 (en) | 2007-12-21 |
| US7893050B2 (en) | 2011-02-22 |
| ATE551059T1 (de) | 2012-04-15 |
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