JP2009513660A5 - - Google Patents
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- Publication number
- JP2009513660A5 JP2009513660A5 JP2008537949A JP2008537949A JP2009513660A5 JP 2009513660 A5 JP2009513660 A5 JP 2009513660A5 JP 2008537949 A JP2008537949 A JP 2008537949A JP 2008537949 A JP2008537949 A JP 2008537949A JP 2009513660 A5 JP2009513660 A5 JP 2009513660A5
- Authority
- JP
- Japan
- Prior art keywords
- additional compound
- combination
- fasudil
- combination medicament
- medicament according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 7
- NGOGFTYYXHNFQH-UHFFFAOYSA-N fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 claims 4
- 229960002435 fasudil Drugs 0.000 claims 4
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 claims 2
- 229960003065 bosentan Drugs 0.000 claims 2
- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 claims 2
- 229960002240 iloprost Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229960003310 sildenafil Drugs 0.000 claims 2
- 208000007718 Stable Angina Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73027305P | 2005-10-26 | 2005-10-26 | |
| PCT/US2006/041830 WO2007050783A2 (en) | 2005-10-26 | 2006-10-25 | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009513660A JP2009513660A (ja) | 2009-04-02 |
| JP2009513660A5 true JP2009513660A5 (enExample) | 2009-08-20 |
Family
ID=37814479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537949A Pending JP2009513660A (ja) | 2005-10-26 | 2006-10-25 | 肺動脈性高血圧の治療用併用療法におけるファスジル |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7893050B2 (enExample) |
| EP (2) | EP2111863B1 (enExample) |
| JP (1) | JP2009513660A (enExample) |
| AT (1) | ATE551059T1 (enExample) |
| WO (1) | WO2007050783A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2580108T3 (es) * | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
| US20070135499A1 (en) * | 2005-07-11 | 2007-06-14 | Aerie Pharmaceuticals, Inc. | Hydrazide compounds |
| WO2007050783A2 (en) | 2005-10-26 | 2007-05-03 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| EP2526948A1 (en) | 2006-09-20 | 2012-11-28 | Aerie Pharmaceuticals, Inc. | RHO kinase inhibitors |
| US20090036465A1 (en) * | 2006-10-18 | 2009-02-05 | United Therapeutics Corporation | Combination therapy for pulmonary arterial hypertension |
| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010103040A1 (en) * | 2009-03-10 | 2010-09-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | 5'-adenosine monophosphate-activated protein kinase (ampk) activators for treating pulmonary hypertension |
| WO2010126626A2 (en) | 2009-05-01 | 2010-11-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| AU2010259943C1 (en) | 2009-06-12 | 2016-03-03 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| AU2010280684B2 (en) * | 2009-08-07 | 2016-07-28 | Scipharm Sarl | Composition for the treatment of cystic fibrosis |
| WO2011149012A1 (ja) * | 2010-05-27 | 2011-12-01 | 参天製薬株式会社 | イソキノリンスルホニル誘導体を有効成分として含有する網脈絡膜変性疾患の予防または治療剤、網脈絡膜変性疾患の予防または治療方法、イソキノリンスルホニル誘導体またはその医薬的に許容される塩、ならびにその使用 |
| RS55624B1 (sr) * | 2011-02-07 | 2017-06-30 | Scipharm Sàrl | Nova kompozicija za lečenje cistične fibroze |
| US8871781B2 (en) | 2011-11-30 | 2014-10-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating a subject for a lymphatic malformation |
| ES2776199T3 (es) | 2013-03-15 | 2020-07-29 | Aerie Pharmaceuticals Inc | Conjugados de compuestos de isoquinolina y prostaglandinas |
| BR112015023168B1 (pt) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina |
| BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
| CA3280124A1 (en) | 2013-07-31 | 2025-10-31 | Avalyn Pharma Inc. | Aerosol imatinib compounds and uses thereof |
| KR102276424B1 (ko) | 2014-10-06 | 2021-07-12 | 삼성전자주식회사 | 로-키나제 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| KR20160049435A (ko) | 2014-10-27 | 2016-05-09 | 삼성전자주식회사 | Atm 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| EP3112466A1 (en) | 2015-07-01 | 2017-01-04 | Samsung Electronics Co., Ltd. | Composition for reducing cellular senescence level including activity inhibitor inhibiting dcun1d3 activity or expression inhibitor inhibiting expression of dcun1d3-encoding gene and use thereof |
| US12048761B2 (en) * | 2015-10-13 | 2024-07-30 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| WO2017086941A1 (en) | 2015-11-17 | 2017-05-26 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| WO2017170981A1 (ja) * | 2016-04-01 | 2017-10-05 | 国立大学法人京都大学 | Ｆｇｆｒ３病の予防または治療剤 |
| WO2018045091A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| BR112019009256A2 (pt) | 2016-11-08 | 2019-07-16 | Reata Pharmaceuticals, Inc. | métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo |
| CA3057872A1 (en) | 2017-03-31 | 2018-10-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| WO2018189246A1 (en) * | 2017-04-11 | 2018-10-18 | Ceva Sante Animale | Method for the treatment of heart disease in mammals |
| US20190125756A1 (en) * | 2017-11-01 | 2019-05-02 | Cipla Limited | Method of treating hypertension |
| WO2020047220A1 (en) * | 2018-08-30 | 2020-03-05 | The Trustees Of Indiana University | Materials and methods for suppressing and/or treating cancer and/or cancer treatment induced cardiac toxicity |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US11413289B2 (en) | 2019-05-16 | 2022-08-16 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
| JP2023550463A (ja) * | 2020-11-23 | 2023-12-01 | エアロベイト セラピューティクス， インコーポレイテッド | イマチニブ処方物、その製造および使用 |
| WO2022245708A1 (en) * | 2021-05-19 | 2022-11-24 | Woolsey Pharmaceuticals, Inc. | Methods of treating depression and anxiety |
| MX2023013538A (es) * | 2021-05-19 | 2023-11-27 | Woolsey Pharmaceuticals Inc | Metodos para tratar la depresion y la ansiedad. |
| CA3236338A1 (en) * | 2021-11-12 | 2023-05-19 | Woolsey Pharmaceuticals, Inc. | Method of treating amyotrophic lateral sclerosis and dosing regimen for same |
| MX2024009983A (es) | 2022-02-17 | 2024-08-26 | Woolsey Pharmaceuticals Inc | Formulaciones orales de fasudil que enmascaran el sabor. |
| MX2024010030A (es) | 2022-02-17 | 2024-09-24 | Woolsey Pharmaceuticals Inc | Formulaciones orales de fasudil con resina de intercambio ionico. |
| CN121463952A (zh) * | 2023-05-12 | 2026-02-03 | 得克萨斯A&M大学系统 | 用于微血管功能障碍及相关疾病的诊断和治疗的组合物和方法 |
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| TW200400821A (en) | 1999-11-02 | 2004-01-16 | Pfizer | Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient |
| AU2002349411A1 (en) | 2001-11-30 | 2003-06-17 | Asahi Kasei Pharma Corporation | Remedies for primary pulmonary hypertension |
| FR2833840B1 (fr) | 2001-12-21 | 2010-06-18 | Rytek | Methodes et compositions pour le traitement de pathologies respiratoires |
| KR101160780B1 (ko) | 2002-08-29 | 2012-06-27 | 산텐 세이야꾸 가부시키가이샤 | Ｒｈｏ 키나아제 억제제 및 프로스타글란딘류를 포함하는 녹내장 치료제 |
| US20040102361A1 (en) * | 2002-11-27 | 2004-05-27 | Frederic Bodin | Pharmaceutical composition for the treatment of pulmonary arterial hypertension |
| US20050101608A1 (en) * | 2003-09-24 | 2005-05-12 | Santel Donald J. | Iloprost in combination therapies for the treatment of pulmonary arterial hypertension |
| WO2007050783A2 (en) | 2005-10-26 | 2007-05-03 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| AT510757B1 (de) | 2010-11-15 | 2014-01-15 | Siemens Ag Oesterreich | System zur fehlersicheren und redundanten übertragung von komplexen daten |
-
2006
- 2006-10-25 WO PCT/US2006/041830 patent/WO2007050783A2/en not_active Ceased
- 2006-10-25 EP EP09007232A patent/EP2111863B1/en not_active Not-in-force
- 2006-10-25 AT AT09007232T patent/ATE551059T1/de active
- 2006-10-25 EP EP06826765A patent/EP1951253A2/en not_active Withdrawn
- 2006-10-25 US US11/588,185 patent/US7893050B2/en not_active Expired - Fee Related
- 2006-10-25 JP JP2008537949A patent/JP2009513660A/ja active Pending
-
2011
- 2011-01-13 US US13/005,954 patent/US20110171139A1/en not_active Abandoned
-
2012
- 2012-09-12 US US13/611,849 patent/US8476259B2/en active Active
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