JP2009513660A5 - - Google Patents

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Publication number
JP2009513660A5
JP2009513660A5 JP2008537949A JP2008537949A JP2009513660A5 JP 2009513660 A5 JP2009513660 A5 JP 2009513660A5 JP 2008537949 A JP2008537949 A JP 2008537949A JP 2008537949 A JP2008537949 A JP 2008537949A JP 2009513660 A5 JP2009513660 A5 JP 2009513660A5
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JP
Japan
Prior art keywords
additional compound
combination
fasudil
combination medicament
medicament according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008537949A
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English (en)
Japanese (ja)
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JP2009513660A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/041830 external-priority patent/WO2007050783A2/en
Publication of JP2009513660A publication Critical patent/JP2009513660A/ja
Publication of JP2009513660A5 publication Critical patent/JP2009513660A5/ja
Pending legal-status Critical Current

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JP2008537949A 2005-10-26 2006-10-25 肺動脈性高血圧の治療用併用療法におけるファスジル Pending JP2009513660A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73027305P 2005-10-26 2005-10-26
PCT/US2006/041830 WO2007050783A2 (en) 2005-10-26 2006-10-25 Fasudil in combination therapies for the treatment of pulmonary arterial hypertension

Publications (2)

Publication Number Publication Date
JP2009513660A JP2009513660A (ja) 2009-04-02
JP2009513660A5 true JP2009513660A5 (enExample) 2009-08-20

Family

ID=37814479

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008537949A Pending JP2009513660A (ja) 2005-10-26 2006-10-25 肺動脈性高血圧の治療用併用療法におけるファスジル

Country Status (5)

Country Link
US (3) US7893050B2 (enExample)
EP (2) EP1951253A2 (enExample)
JP (1) JP2009513660A (enExample)
AT (1) ATE551059T1 (enExample)
WO (1) WO2007050783A2 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007008942A2 (en) * 2005-07-11 2007-01-18 Aerie Pharmaceuticals, Inc. Phenylamino-acetic acid [1-(pyridin-4-yl)-methylidene]-hydrazide derivatives and related compounds as modulators of g protein-coupled receptor kinases for the treatment of eye diseases
WO2007008926A1 (en) * 2005-07-11 2007-01-18 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
CA2664335C (en) 2006-09-20 2014-12-02 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
WO2008049000A2 (en) * 2006-10-18 2008-04-24 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) * 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) * 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
WO2010103040A1 (en) * 2009-03-10 2010-09-16 INSERM (Institut National de la Santé et de la Recherche Médicale) 5'-adenosine monophosphate-activated protein kinase (ampk) activators for treating pulmonary hypertension
ES2553827T3 (es) * 2009-05-01 2015-12-14 Aerie Pharmaceuticals, Inc. Inhibidores de mecanismo doble para el tratamiento de enfermedad
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
SG178315A1 (en) * 2009-08-07 2012-03-29 Scipharm Sarl Composition for the treatment of cystic fibrosis
JP2012006918A (ja) * 2010-05-27 2012-01-12 Santen Pharmaceut Co Ltd イソキノリンスルホニル誘導体を有効成分として含有する網脈絡膜変性疾患の予防または治療剤
HUE031652T2 (en) 2011-02-07 2017-07-28 Scipharm Sarl New composition for treating cystic fibrosis
US8871781B2 (en) 2011-11-30 2014-10-28 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating a subject for a lymphatic malformation
KR102391750B1 (ko) 2013-03-15 2022-04-28 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
HUE061618T2 (hu) 2013-03-15 2023-07-28 Aerie Pharmaceuticals Inc Vegyület szemrendellenességek kezelésére
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
AU2014296032A1 (en) 2013-07-31 2016-03-17 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
KR102276424B1 (ko) 2014-10-06 2021-07-12 삼성전자주식회사 로-키나제 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도
KR20160049435A (ko) 2014-10-27 2016-05-09 삼성전자주식회사 Atm 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도
EP3112466A1 (en) 2015-07-01 2017-01-04 Samsung Electronics Co., Ltd. Composition for reducing cellular senescence level including activity inhibitor inhibiting dcun1d3 activity or expression inhibitor inhibiting expression of dcun1d3-encoding gene and use thereof
US12048761B2 (en) * 2015-10-13 2024-07-30 Inserm (Institut National De La Santé Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102579582B1 (ko) 2015-11-17 2023-09-15 에어리 파마슈티컬즈, 인코포레이티드 키나아제 억제제 및 이의 중간체의 제조 방법
WO2017170981A1 (ja) * 2016-04-01 2017-10-05 国立大学法人京都大学 Fgfr3病の予防または治療剤
WO2018045091A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
CA3042123A1 (en) 2016-11-08 2018-05-17 Reata Pharmaceuticals, Inc. Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
JP2020515583A (ja) 2017-03-31 2020-05-28 アエリエ ファーマシューティカルズ インコーポレイテッド アリールシクロプロピル−アミノ−イソキノリニルアミド化合物
LT3609486T (lt) * 2017-04-11 2021-10-11 Ceva Santé Animale Sarpogrelatas, skirtas naudoti žinduolių širdies ligų gydymo būdui
US20190125756A1 (en) * 2017-11-01 2019-05-02 Cipla Limited Method of treating hypertension
WO2020047220A1 (en) * 2018-08-30 2020-03-05 The Trustees Of Indiana University Materials and methods for suppressing and/or treating cancer and/or cancer treatment induced cardiac toxicity
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2020232238A1 (en) 2019-05-16 2020-11-19 Aerovate Therapeutics, Inc. Inhalable formulations for kinase inhibition
AU2021382051A1 (en) * 2020-11-23 2023-06-08 Aerovate Therapeutics, Inc. Imatinib formulations, manufacture, and uses thereof
US20240252511A1 (en) * 2021-05-19 2024-08-01 Woolsey Pharmaceuticals, Inc. Methods of treating depression and anxiety
US20240261298A1 (en) * 2021-05-19 2024-08-08 Woolsey Pharmaceuticals, Inc. Methods of treating depression and anxiety
MX2024005745A (es) * 2021-11-12 2024-05-28 Woolsey Pharmaceuticals Inc Metodo para tratar la esclerosis lateral amiotrofica y la pauta posologica para la misma.
US20250144113A1 (en) 2022-02-17 2025-05-08 Woolsey Pharmaceuticals, Inc. Taste-masking oral formulations of fasudil
MX2024010030A (es) * 2022-02-17 2024-09-24 Woolsey Pharmaceuticals Inc Formulaciones orales de fasudil con resina de intercambio ionico.
WO2024238454A2 (en) * 2023-05-12 2024-11-21 The Texas A&M University System Compositions and methods for the diagnosis and treatment of microvasculature dysfunction and related diseases

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US326704A (en) * 1885-09-22 James h
US2882271A (en) 1959-04-14 Xcixcxh
US377393A (en) * 1888-02-07 Dyeing or scouring machine
US3746A (en) * 1844-09-17 Improvement in coating iron and copper with tin and other metals
US110553A (en) * 1870-12-27 Improvement in preventing incrustation of steam-boilers
US56403A (en) * 1866-07-17 Improved machine for grinding cutlery
US870767A (en) * 1907-02-11 1907-11-12 Robert J Emory & Company Spooling-machine.
NL238796A (enExample) 1958-05-07
US3047591A (en) * 1959-08-31 1962-07-31 British Drug Houses Ltd Preparation of 17alpha-acyloxy-6alpha-methyl-16-methylenepregn-4-ene-3,20-diones
DE1265758B (de) 1960-05-25 1968-04-11 Guidotti & C Spa Labor Verfahren zur Herstellung von o-(beta-Dialkylaminoaethoxy)-phenylketonen und deren Saeureadditionssalzen und quartaeren Salzen
SE300218B (enExample) 1960-11-08 1968-04-22 Recip Ab
DE1154810B (de) 1961-04-01 1963-09-26 Knoll Ag Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
US3262977A (en) * 1962-03-10 1966-07-26 Chinoin Gyogyszer Es Vegyeszet N-aralkyl-1, 1-diphenyl-propylamine derivatives
BR6464291D0 (pt) 1963-11-26 1973-07-26 Merrell Inc Richardson Processo para preparar o novo composto quimico 1-1-di cloro-hexil-2-(2-piperidil)-etina
NL137318C (enExample) 1964-06-09
FR1406805A (fr) 1964-08-17 1965-07-23 Egyt Gyogyszervegyeszeti Gyar Procédé de préparation de nouveaux éthers basiques de cycloalkanols substitués
DE1670827C3 (de) 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3773939A (en) 1971-11-24 1973-11-20 Janssen Pharmaceutica Nv N-arallyl-n'-aralkyl piperazine pharmaceutical compositions
BE795735A (fr) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay Nouvelles ethylenediamines substituees a activite cardiovasculaire
US3985758A (en) 1973-02-20 1976-10-12 Yamanouchi Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives
US4338322A (en) * 1975-07-02 1982-07-06 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same
US4154839A (en) 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
US4466972A (en) 1977-06-20 1984-08-21 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
JPS55301A (en) 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
SE429652B (sv) 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
GB2111978B (en) 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
ATE50987T1 (de) * 1982-05-10 1990-03-15 Takeda Chemical Industries Ltd Dihydropyridinderivate, deren herstellung und verwendung.
DE3382204D1 (de) 1982-10-15 1991-04-18 Kyowa Hakko Kogyo Kk 1,4-dihydropyridin-derivate.
US4451244A (en) 1982-11-30 1984-05-29 Borg-Warner Corporation Series vibration damper with non-symmetrical curve
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
JPS60222472A (ja) 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
US4672068A (en) 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
ATE71622T1 (de) 1985-07-29 1992-02-15 Santen Pharmaceutical Co Ltd Neue benzothiazinabkoemmlinge.
US4885284A (en) 1986-01-22 1989-12-05 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic propylene ester
CA1319144C (en) * 1986-11-14 1993-06-15 Quirico Branca Tetrahydronaphthalene derivatives
ATE61588T1 (de) * 1987-08-03 1991-03-15 Delagrange Lab 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
JPH06141894A (ja) 1992-11-11 1994-05-24 Asahi Chem Ind Co Ltd ミオシン軽鎖リン酸化酵素の活性測定法
ES2142065T3 (es) 1995-07-03 2000-04-01 Asahi Chemical Ind Clorhidratos de 1-(5-isoquinoleinsulfonil)homopiperazina hidratado.
KR100576148B1 (ko) * 1996-08-12 2006-05-03 미쯔비시 웰 파마 가부시키가이샤 Rho 키나아제 억제제를 함유하는 약제
US6147109A (en) 1997-10-14 2000-11-14 The General Hospital Corporation Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors
US6180597B1 (en) 1998-03-19 2001-01-30 Brigham And Women's Hospital, Inc. Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors
AU4990599A (en) 1998-07-14 2000-02-07 Brigham And Women's Hospital Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization
EP1175246A4 (en) 1999-03-19 2004-12-15 Brigham & Womens Hospital POSITIVE REGULATION OF NITRIC OXIDE SYNTHASE OF TYPE III ENDOTHELIAL CELLS BY HMG-COA REDUCTASE INHIBITORS
US6228843B1 (en) * 1999-04-23 2001-05-08 University Technology Corporation Method of using PKC inhibiting compounds to treat vascular disease
TWI224966B (en) 1999-11-02 2004-12-11 Pfizer Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient
AU2002349411A1 (en) 2001-11-30 2003-06-17 Asahi Kasei Pharma Corporation Remedies for primary pulmonary hypertension
FR2833840B1 (fr) * 2001-12-21 2010-06-18 Rytek Methodes et compositions pour le traitement de pathologies respiratoires
AU2003257588A1 (en) 2002-08-29 2004-03-19 Santen Pharmaceutical Co., Ltd. REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND PROSTAGLANDINS
US20040102361A1 (en) * 2002-11-27 2004-05-27 Frederic Bodin Pharmaceutical composition for the treatment of pulmonary arterial hypertension
US20050101608A1 (en) * 2003-09-24 2005-05-12 Santel Donald J. Iloprost in combination therapies for the treatment of pulmonary arterial hypertension
ATE551059T1 (de) 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
AT510757B1 (de) 2010-11-15 2014-01-15 Siemens Ag Oesterreich System zur fehlersicheren und redundanten übertragung von komplexen daten

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