JP2009513113A5 - - Google Patents

Info

Publication number

JP2009513113A5

JP2009513113A5 JP2008536898A JP2008536898A JP2009513113A5 JP 2009513113 A5 JP2009513113 A5 JP 2009513113A5 JP 2008536898 A JP2008536898 A JP 2008536898A JP 2008536898 A JP2008536898 A JP 2008536898A JP 2009513113 A5 JP2009513113 A5 JP 2009513113A5

Authority

JP

Japan

Prior art keywords

protease

substrate

seq

sample

self

Prior art date

2006-10-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 238000000034 method Methods 0.000 claims 14
• 239000000758 substrate Substances 0.000 claims 14
• 108091005804 Peptidases Proteins 0.000 claims 12
• 239000004365 Protease Substances 0.000 claims 12
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 12
• 239000006227 byproduct Substances 0.000 claims 7
• 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims 6
• 239000000047 product Substances 0.000 claims 6
• 101800001020 Non-structural protein 4A Proteins 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 4
• NLEBIOOXCVAHBD-QKMCSOCLSA-N dodecyl beta-D-maltoside Chemical compound O[C@@H]1[C@@H](O)[C@H](OCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 NLEBIOOXCVAHBD-QKMCSOCLSA-N 0.000 claims 4
• 238000003776 cleavage reaction Methods 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 2
• OGGIFKYAUCDPFX-UHFFFAOYSA-N n,n-diethyldodecan-1-amine oxide Chemical compound CCCCCCCCCCCC[N+]([O-])(CC)CC OGGIFKYAUCDPFX-UHFFFAOYSA-N 0.000 claims 2
• 230000007017 scission Effects 0.000 claims 2
• 239000004094 surface-active agent Substances 0.000 claims 2
• WCKQPPQRFNHPRJ-UHFFFAOYSA-N 4-[[4-(dimethylamino)phenyl]diazenyl]benzoic acid Chemical compound C1=CC(N(C)C)=CC=C1N=NC1=CC=C(C(O)=O)C=C1 WCKQPPQRFNHPRJ-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• SJQRQOKXQKVJGJ-UHFFFAOYSA-N 5-(2-aminoethylamino)naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(NCCN)=CC=CC2=C1S(O)(=O)=O SJQRQOKXQKVJGJ-UHFFFAOYSA-N 0.000 claims 1
• 108091035707 Consensus sequence Proteins 0.000 claims 1
• 108010002156 Depsipeptides Proteins 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1