JP2018532384A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018532384A5 JP2018532384A5 JP2018511420A JP2018511420A JP2018532384A5 JP 2018532384 A5 JP2018532384 A5 JP 2018532384A5 JP 2018511420 A JP2018511420 A JP 2018511420A JP 2018511420 A JP2018511420 A JP 2018511420A JP 2018532384 A5 JP2018532384 A5 JP 2018532384A5
- Authority
- JP
- Japan
- Prior art keywords
- lsp
- compound
- assay system
- enzyme
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562214695P | 2015-09-04 | 2015-09-04 | |
| US62/214,695 | 2015-09-04 | ||
| PCT/US2016/049869 WO2017040762A2 (en) | 2015-09-04 | 2016-09-01 | Methods for identifying novel antibiotics and related compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532384A JP2018532384A (ja) | 2018-11-08 |
| JP2018532384A5 true JP2018532384A5 (https=) | 2019-10-03 |
Family
ID=58189060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511420A Pending JP2018532384A (ja) | 2015-09-04 | 2016-09-01 | 新規な抗生物質を同定するための方法および関連組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190144912A1 (https=) |
| EP (1) | EP3344043A4 (https=) |
| JP (1) | JP2018532384A (https=) |
| CN (1) | CN108135181A (https=) |
| CA (1) | CA2997530A1 (https=) |
| WO (1) | WO2017040762A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200181101A1 (en) * | 2017-07-05 | 2020-06-11 | The Scripps Research Institute | Benzamide inhibitors of bacterial lipoprotein signal peptidase |
| EP3587382A1 (en) * | 2018-06-28 | 2020-01-01 | Rheinische Friedrich-Wilhelms-Universität Bonn | Click-mass spectrometry of alkyne-labeled compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62236494A (ja) * | 1986-04-08 | 1987-10-16 | Sumitomo Chem Co Ltd | シグナルペプチダ−ゼに対するモノクロ−ナル抗体、およびそれを産生するハイブリド−マ |
| CA2032914A1 (en) * | 1989-12-26 | 1991-06-27 | Peter C.K. Lau | Use of bacterial lipoprotein amino terminus in fusion plasmids for in vivo expression of lipid modified polypeptides |
| US7888005B2 (en) * | 2003-02-12 | 2011-02-15 | The Curators Of The University Of Missouri | Inhibitors of macromolecular activity |
| FR2890446B1 (fr) * | 2005-09-05 | 2008-04-18 | Cis Bio Internat Sa | Methode de detection d'interaction intracellulaire entre bio-molecules |
| BRPI0818162B1 (pt) * | 2007-10-10 | 2023-11-07 | Givaudan Sa | Método para identificar modulador da formação de mau cheiro no corpo, kit, método para inibir peptidase em sua capacidade de clivar seu substrato e método para formar peptidase |
| GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| US20130012687A1 (en) * | 2009-09-21 | 2013-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Inducible self-cleaving protease tag and method of purifying recombinant proteins using the same |
| CN103502466A (zh) * | 2010-09-07 | 2014-01-08 | 斯隆－凯特林纪念癌症中心 | 用于γ-分泌酶测定的方法和组合物 |
| EP2612916A1 (en) * | 2012-01-09 | 2013-07-10 | Universität Zürich | Cellular high throughput encapsulation for screening or selection |
| JP6327662B2 (ja) * | 2012-09-26 | 2018-05-23 | 学校法人藤田学園 | 細胞表面タンパクを抗原とする抗体を測定する方法 |
| GB201222833D0 (en) * | 2012-12-18 | 2013-01-30 | Isis Innovation | Detection of membrane proteins |
| US20140287447A1 (en) * | 2013-03-14 | 2014-09-25 | Ronald R. Fiscus | Ultrasensitive methodology for quantifying the kinase catalytic activity of any protein kinase in biological/clinical samples or recombinant/purified proteins using near-infrared-fluorescence (NIRF)-labeled, kinase-selective peptide substrates and a combination of kinase-selective inhibitors to define individual kinase activity |
-
2016
- 2016-09-01 CA CA2997530A patent/CA2997530A1/en not_active Abandoned
- 2016-09-01 CN CN201680058081.8A patent/CN108135181A/zh active Pending
- 2016-09-01 EP EP16842970.2A patent/EP3344043A4/en not_active Withdrawn
- 2016-09-01 WO PCT/US2016/049869 patent/WO2017040762A2/en not_active Ceased
- 2016-09-01 JP JP2018511420A patent/JP2018532384A/ja active Pending
- 2016-09-01 US US15/756,741 patent/US20190144912A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kitamura et al. | Expedited approach toward the rational design of noncovalent SARS-CoV-2 main protease inhibitors | |
| Mensa et al. | Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16 | |
| Ogilvie et al. | Peptidomimetic inhibitors of the human cytomegalovirus protease | |
| Bogyo et al. | Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs | |
| Osman et al. | Why all the fury over furin? | |
| Weigel et al. | Phenylalanine and phenylglycine analogues as arginine mimetics in dengue protease inhibitors | |
| Loregian et al. | Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase | |
| US20240083885A1 (en) | Compositions and methods for inhibiting m pro protease activity and for preventing and treating sars-cov-2 infection | |
| US9187524B2 (en) | Broad spectrum antibiotic arylomycin analogs | |
| MD Bastos et al. | Parasite prolyl oligopeptidases and the challenge of designing chemotherapeuticals for Chagas disease, leishmaniasis and African trypanosomiasis | |
| US20160297851A1 (en) | Broad spectrum antibiotic arylomycin analogs | |
| JP2010506166A (ja) | デング熱の診断及び治療 | |
| Breuning et al. | Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids | |
| WO2005043118A2 (en) | Drug discovery method | |
| Weisshaar et al. | Identification and characterization of influenza virus entry inhibitors through dual myxovirus high-throughput screening | |
| Xu et al. | A commensal dipeptidyl aminopeptidase with specificity for N-terminal glycine degrades human-produced antimicrobial peptides in vitro | |
| Ridgway et al. | Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies | |
| JP2018532384A5 (https=) | ||
| Lange et al. | Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors | |
| US20240401101A1 (en) | A live cell assay to determine permeability of test molecules to and/or within the peptidoglycan scaffold of bacteria cells | |
| EP2365091A1 (en) | Method of screening for HtrA protease inhibitors useful for prophylaxis and therapy of a bacterial infection | |
| EP3097124B1 (en) | Means and methods for detecting activated malt1 | |
| Brennan et al. | Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus | |
| Heal et al. | Application of activity-based protein profiling to the study of microbial pathogenesis | |
| JP2008538178A5 (https=) |