JP2018532384A - 新規な抗生物質を同定するための方法および関連組成物 - Google Patents

新規な抗生物質を同定するための方法および関連組成物 Download PDF

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JP2018532384A
JP2018532384A JP2018511420A JP2018511420A JP2018532384A JP 2018532384 A JP2018532384 A JP 2018532384A JP 2018511420 A JP2018511420 A JP 2018511420A JP 2018511420 A JP2018511420 A JP 2018511420A JP 2018532384 A JP2018532384 A JP 2018532384A
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lsp
compound
enzyme
assay
bacterial
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JP2018532384A5 (https=
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ウォラン，デニス・ダブリュー
オーウェンズビー，アンナ
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ザ スクリプス リサーチ インスティテュート
ザ スクリプス リサーチ インスティテュート
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23036—Signal peptidase II (3.4.23.36)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2018511420A 2015-09-04 2016-09-01 新規な抗生物質を同定するための方法および関連組成物 Pending JP2018532384A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562214695P 2015-09-04 2015-09-04
US62/214,695 2015-09-04
PCT/US2016/049869 WO2017040762A2 (en) 2015-09-04 2016-09-01 Methods for identifying novel antibiotics and related compositions

Publications (2)

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JP2018532384A true JP2018532384A (ja) 2018-11-08
JP2018532384A5 JP2018532384A5 (https=) 2019-10-03

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US (1) US20190144912A1 (https=)
EP (1) EP3344043A4 (https=)
JP (1) JP2018532384A (https=)
CN (1) CN108135181A (https=)
CA (1) CA2997530A1 (https=)
WO (1) WO2017040762A2 (https=)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
US20200181101A1 (en) * 2017-07-05 2020-06-11 The Scripps Research Institute Benzamide inhibitors of bacterial lipoprotein signal peptidase
EP3587382A1 (en) * 2018-06-28 2020-01-01 Rheinische Friedrich-Wilhelms-Universität Bonn Click-mass spectrometry of alkyne-labeled compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014081365A (ja) * 2012-09-26 2014-05-08 Fujita Gakuen 細胞表面タンパクを抗原とする抗体を測定する方法
JP2015503926A (ja) * 2012-01-09 2015-02-05 ウニヴェルズィテート チューリッヒ スクリーニングまたは選択のための細胞ハイスループット封入
JP2015133973A (ja) * 2007-12-08 2015-07-27 ヘプタレス セラピューティックス リミテッド 変異体タンパク質とその製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62236494A (ja) * 1986-04-08 1987-10-16 Sumitomo Chem Co Ltd シグナルペプチダ−ゼに対するモノクロ−ナル抗体、およびそれを産生するハイブリド−マ
CA2032914A1 (en) * 1989-12-26 1991-06-27 Peter C.K. Lau Use of bacterial lipoprotein amino terminus in fusion plasmids for in vivo expression of lipid modified polypeptides
US7888005B2 (en) * 2003-02-12 2011-02-15 The Curators Of The University Of Missouri Inhibitors of macromolecular activity
FR2890446B1 (fr) * 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
BRPI0818162B1 (pt) * 2007-10-10 2023-11-07 Givaudan Sa Método para identificar modulador da formação de mau cheiro no corpo, kit, método para inibir peptidase em sua capacidade de clivar seu substrato e método para formar peptidase
US20130012687A1 (en) * 2009-09-21 2013-01-10 The Board Of Trustees Of The Leland Stanford Junior University Inducible self-cleaving protease tag and method of purifying recombinant proteins using the same
CN103502466A (zh) * 2010-09-07 2014-01-08 斯隆－凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物
GB201222833D0 (en) * 2012-12-18 2013-01-30 Isis Innovation Detection of membrane proteins
US20140287447A1 (en) * 2013-03-14 2014-09-25 Ronald R. Fiscus Ultrasensitive methodology for quantifying the kinase catalytic activity of any protein kinase in biological/clinical samples or recombinant/purified proteins using near-infrared-fluorescence (NIRF)-labeled, kinase-selective peptide substrates and a combination of kinase-selective inhibitors to define individual kinase activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015133973A (ja) * 2007-12-08 2015-07-27 ヘプタレス セラピューティックス リミテッド 変異体タンパク質とその製造方法
JP2015503926A (ja) * 2012-01-09 2015-02-05 ウニヴェルズィテート チューリッヒ スクリーニングまたは選択のための細胞ハイスループット封入
JP2014081365A (ja) * 2012-09-26 2014-05-08 Fujita Gakuen 細胞表面タンパクを抗原とする抗体を測定する方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AN. ACAD. BRAS. CIENC., vol. 81, no. 3, JPN7020002757, 2009, pages 381 - 392, ISSN: 0004479320 *
FEBS LETT., vol. 166, no. 1, JPN6020033718, 1984, pages 179 - 182, ISSN: 0004479319 *
FEBS LETT., vol. 173, no. 1, JPN6020033717, 1984, pages 264 - 268, ISSN: 0004479318 *

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Publication number Publication date
CN108135181A (zh) 2018-06-08
WO2017040762A2 (en) 2017-03-09
CA2997530A1 (en) 2017-03-09
US20190144912A1 (en) 2019-05-16
EP3344043A2 (en) 2018-07-11
EP3344043A4 (en) 2019-07-10
WO2017040762A3 (en) 2017-07-13

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