CA2997530A1 - Methods for identifying novel antibiotics and related compositions - Google Patents
Methods for identifying novel antibiotics and related compositions Download PDFInfo
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- CA2997530A1 CA2997530A1 CA2997530A CA2997530A CA2997530A1 CA 2997530 A1 CA2997530 A1 CA 2997530A1 CA 2997530 A CA2997530 A CA 2997530A CA 2997530 A CA2997530 A CA 2997530A CA 2997530 A1 CA2997530 A1 CA 2997530A1
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/23—Aspartic endopeptidases (3.4.23)
- C12Y304/23036—Signal peptidase II (3.4.23.36)
Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
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| US201562214695P | 2015-09-04 | 2015-09-04 | |
| US62/214,695 | 2015-09-04 | ||
| PCT/US2016/049869 WO2017040762A2 (en) | 2015-09-04 | 2016-09-01 | Methods for identifying novel antibiotics and related compositions |
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| CA2997530A1 true CA2997530A1 (en) | 2017-03-09 |
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| EP (1) | EP3344043A4 (https=) |
| JP (1) | JP2018532384A (https=) |
| CN (1) | CN108135181A (https=) |
| CA (1) | CA2997530A1 (https=) |
| WO (1) | WO2017040762A2 (https=) |
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| US20200181101A1 (en) * | 2017-07-05 | 2020-06-11 | The Scripps Research Institute | Benzamide inhibitors of bacterial lipoprotein signal peptidase |
| EP3587382A1 (en) * | 2018-06-28 | 2020-01-01 | Rheinische Friedrich-Wilhelms-Universität Bonn | Click-mass spectrometry of alkyne-labeled compounds |
Family Cites Families (12)
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| JPS62236494A (ja) * | 1986-04-08 | 1987-10-16 | Sumitomo Chem Co Ltd | シグナルペプチダ−ゼに対するモノクロ−ナル抗体、およびそれを産生するハイブリド−マ |
| CA2032914A1 (en) * | 1989-12-26 | 1991-06-27 | Peter C.K. Lau | Use of bacterial lipoprotein amino terminus in fusion plasmids for in vivo expression of lipid modified polypeptides |
| US7888005B2 (en) * | 2003-02-12 | 2011-02-15 | The Curators Of The University Of Missouri | Inhibitors of macromolecular activity |
| FR2890446B1 (fr) * | 2005-09-05 | 2008-04-18 | Cis Bio Internat Sa | Methode de detection d'interaction intracellulaire entre bio-molecules |
| BRPI0818162B1 (pt) * | 2007-10-10 | 2023-11-07 | Givaudan Sa | Método para identificar modulador da formação de mau cheiro no corpo, kit, método para inibir peptidase em sua capacidade de clivar seu substrato e método para formar peptidase |
| GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| US20130012687A1 (en) * | 2009-09-21 | 2013-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Inducible self-cleaving protease tag and method of purifying recombinant proteins using the same |
| CN103502466A (zh) * | 2010-09-07 | 2014-01-08 | 斯隆－凯特林纪念癌症中心 | 用于γ-分泌酶测定的方法和组合物 |
| EP2612916A1 (en) * | 2012-01-09 | 2013-07-10 | Universität Zürich | Cellular high throughput encapsulation for screening or selection |
| JP6327662B2 (ja) * | 2012-09-26 | 2018-05-23 | 学校法人藤田学園 | 細胞表面タンパクを抗原とする抗体を測定する方法 |
| GB201222833D0 (en) * | 2012-12-18 | 2013-01-30 | Isis Innovation | Detection of membrane proteins |
| US20140287447A1 (en) * | 2013-03-14 | 2014-09-25 | Ronald R. Fiscus | Ultrasensitive methodology for quantifying the kinase catalytic activity of any protein kinase in biological/clinical samples or recombinant/purified proteins using near-infrared-fluorescence (NIRF)-labeled, kinase-selective peptide substrates and a combination of kinase-selective inhibitors to define individual kinase activity |
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Also Published As
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| CN108135181A (zh) | 2018-06-08 |
| WO2017040762A2 (en) | 2017-03-09 |
| JP2018532384A (ja) | 2018-11-08 |
| US20190144912A1 (en) | 2019-05-16 |
| EP3344043A2 (en) | 2018-07-11 |
| EP3344043A4 (en) | 2019-07-10 |
| WO2017040762A3 (en) | 2017-07-13 |
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