JP2005503824A5 - - Google Patents
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- Publication number
- JP2005503824A5 JP2005503824A5 JP2003532668A JP2003532668A JP2005503824A5 JP 2005503824 A5 JP2005503824 A5 JP 2005503824A5 JP 2003532668 A JP2003532668 A JP 2003532668A JP 2003532668 A JP2003532668 A JP 2003532668A JP 2005503824 A5 JP2005503824 A5 JP 2005503824A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- hdac9
- nucleic acid
- activity
- histone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 56
- 108090000765 processed proteins & peptides Proteins 0.000 claims 56
- 102000004196 processed proteins & peptides Human genes 0.000 claims 56
- 101710177326 Histone deacetylase 9 Proteins 0.000 claims 51
- 102100038720 Histone deacetylase 9 Human genes 0.000 claims 51
- 238000000034 method Methods 0.000 claims 24
- 230000000694 effects Effects 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000007523 nucleic acids Chemical group 0.000 claims 16
- 239000000758 substrate Substances 0.000 claims 15
- 108010033040 Histones Proteins 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 7
- 102000003964 Histone deacetylase Human genes 0.000 claims 6
- 108090000353 Histone deacetylase Proteins 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 108091007494 Nucleic acid- binding domains Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 102100039556 Galectin-4 Human genes 0.000 claims 3
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 230000003828 downregulation Effects 0.000 claims 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 102000006947 Histones Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108700019889 TEL-AML1 fusion Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000006196 deacetylation Effects 0.000 claims 2
- 238000003381 deacetylation reaction Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108700024394 Exon Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- -1 label Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0123664.5A GB0123664D0 (en) | 2001-10-02 | 2001-10-02 | Histone deacetylase 9 |
| PCT/GB2002/004455 WO2003029451A2 (en) | 2001-10-02 | 2002-10-02 | Histone deacetylase 9 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503824A JP2005503824A (ja) | 2005-02-10 |
| JP2005503824A5 true JP2005503824A5 (https=) | 2006-01-05 |
| JP4383170B2 JP4383170B2 (ja) | 2009-12-16 |
Family
ID=9923113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532668A Expired - Fee Related JP4383170B2 (ja) | 2001-10-02 | 2002-10-02 | ヒストン脱アセチル化酵素９ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7291492B2 (https=) |
| EP (1) | EP1432792B1 (https=) |
| JP (1) | JP4383170B2 (https=) |
| AT (1) | ATE340257T1 (https=) |
| DE (1) | DE60214867T2 (https=) |
| GB (1) | GB0123664D0 (https=) |
| WO (1) | WO2003029451A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002318364A1 (en) | 2001-06-14 | 2003-01-02 | Bristol-Myers Squibb Company | Novel human histone deacetylases |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7381825B2 (en) | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0321694D0 (en) * | 2003-09-16 | 2003-10-15 | Ark Therapeutics Ltd | Genes and their therapeutic use |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1896436A2 (en) | 2005-05-11 | 2008-03-12 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EA200800321A1 (ru) | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| WO2008039461A2 (en) * | 2006-09-27 | 2008-04-03 | Thinsilicon Corp. | Back contact device for photovoltaic cells and method of manufacturing a back contact |
| WO2008150769A2 (en) * | 2007-05-31 | 2008-12-11 | Thinsilicon Corporation | Photovoltaic device and method of manufacturing photovoltaic devices |
| MX2010003371A (es) | 2007-09-28 | 2010-05-05 | Intrexon Corp | Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos. |
| US8623853B2 (en) | 2008-07-23 | 2014-01-07 | The Brigham And Women's Hospital, Inc. | Treatment of cancers characterized by chromosomal rearrangement of the NUT gene |
| KR101319674B1 (ko) * | 2009-05-06 | 2013-10-17 | 씬실리콘 코포레이션 | 광기전 전지 및 반도체층 적층체에서의 광 포획성 향상 방법 |
| WO2010144459A2 (en) * | 2009-06-10 | 2010-12-16 | Thinsilicon Corporation | Photovoltaic modules and methods for manufacturing photovoltaic modules having tandem semiconductor layer stacks |
| US20110114156A1 (en) * | 2009-06-10 | 2011-05-19 | Thinsilicon Corporation | Photovoltaic modules having a built-in bypass diode and methods for manufacturing photovoltaic modules having a built-in bypass diode |
| US11441672B2 (en) * | 2019-10-29 | 2022-09-13 | Lokar, Inc. | Adjustable shift lever mount |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE320484T1 (de) | 1999-12-08 | 2006-04-15 | Axys Pharm Inc | Histone-deacetylase-8 proteine, nukleinsäuren und methoden zur verwendung |
| WO2002036783A2 (en) | 2000-10-31 | 2002-05-10 | Bayer Aktiengesellschaft | Regulation of human histone deacetylase |
| US20040077046A1 (en) | 2000-12-20 | 2004-04-22 | Dalia Cohen | Histone deacetylase-related gene and protein |
| CA2465075A1 (en) * | 2001-06-14 | 2002-12-27 | Sloan-Kettering Institute For Cancer Research | Hdac9 polypeptides and polynucleotides and uses thereof |
| AU2002318364A1 (en) * | 2001-06-14 | 2003-01-02 | Bristol-Myers Squibb Company | Novel human histone deacetylases |
-
2001
- 2001-10-02 GB GBGB0123664.5A patent/GB0123664D0/en not_active Ceased
-
2002
- 2002-10-02 EP EP02765071A patent/EP1432792B1/en not_active Expired - Lifetime
- 2002-10-02 WO PCT/GB2002/004455 patent/WO2003029451A2/en not_active Ceased
- 2002-10-02 AT AT02765071T patent/ATE340257T1/de not_active IP Right Cessation
- 2002-10-02 US US10/491,372 patent/US7291492B2/en not_active Expired - Fee Related
- 2002-10-02 JP JP2003532668A patent/JP4383170B2/ja not_active Expired - Fee Related
- 2002-10-02 DE DE60214867T patent/DE60214867T2/de not_active Expired - Lifetime
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