JP2009513113A - Ｃ型肝炎ウイルスｎｓ２／３活性のアッセイ法 - Google Patents

Ｃ型肝炎ウイルスｎｓ２／３活性のアッセイ法 Download PDF

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Publication number
JP2009513113A
JP2009513113A JP2008536898A JP2008536898A JP2009513113A JP 2009513113 A JP2009513113 A JP 2009513113A JP 2008536898 A JP2008536898 A JP 2008536898A JP 2008536898 A JP2008536898 A JP 2008536898A JP 2009513113 A JP2009513113 A JP 2009513113A
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Prior art keywords
protease
substrate
seq
assay
cleavage
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Japanese (ja)
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JP2009513113A5 (https=
Inventor
ロジャー モーリス
ダイアン ティボール
Original Assignee
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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Publication of JP2009513113A publication Critical patent/JP2009513113A/ja
Publication of JP2009513113A5 publication Critical patent/JP2009513113A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2008536898A 2005-10-28 2006-10-27 Ｃ型肝炎ウイルスｎｓ２／３活性のアッセイ法 Pending JP2009513113A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73099905P 2005-10-28 2005-10-28
PCT/CA2006/001773 WO2007048254A1 (en) 2005-10-28 2006-10-27 Hepatitis c virus ns2/3 activity assay

Publications (2)

Publication Number Publication Date
JP2009513113A true JP2009513113A (ja) 2009-04-02
JP2009513113A5 JP2009513113A5 (https=) 2009-12-17

Family

ID=37967381

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008536898A Pending JP2009513113A (ja) 2005-10-28 2006-10-27 Ｃ型肝炎ウイルスｎｓ２／３活性のアッセイ法

Country Status (7)

Country Link
US (1) US7655394B2 (https=)
EP (1) EP1945797B1 (https=)
JP (1) JP2009513113A (https=)
CA (1) CA2627247C (https=)
DK (1) DK1945797T3 (https=)
ES (1) ES2386462T3 (https=)
WO (1) WO2007048254A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070141701A1 (en) * 2005-12-21 2007-06-21 Boehringer Ingelheim International Gmbh Hepatitis c virus ns2/3 assay
MX2009008439A (es) * 2007-02-12 2009-08-13 Intermune Inc Nuevos inhibidores de la replicacion del virus de hepatitis c.
EA036483B1 (ru) * 2012-11-12 2020-11-16 Эпитоп Интернэшнл Нв Пептиды, способные индуцировать толерантность к рекомбинантному fviii, содержащая их композиция, их применение и способ лечения гемофилии

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08205893A (ja) * 1994-12-08 1996-08-13 Sumitomo Metal Ind Ltd Ｈｃｖプロテアーゼ活性測定法
JP2002530430A (ja) * 1998-11-26 2002-09-17 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Ｃ型肝炎ウイルスｎｓ３プロテアーゼ阻害用の医薬組成物
JP2003526361A (ja) * 2000-03-17 2003-09-09 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Ｈｃｖｎｓ２／３フラグメント及びその使用
JP2005523016A (ja) * 2002-04-19 2005-08-04 アマシャム・バイオサイエンス・コーポレイション 熱安定性ｄｎａポリメラーゼ及びその製造方法
WO2005073216A2 (en) * 2004-01-30 2005-08-11 Medivir Ab Hcv ns-3 serine protease inhibitors

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US4372755A (en) * 1978-07-27 1983-02-08 Enrecon, Inc. Production of a fuel gas with a stabilized metal carbide catalyst
DE3133562C2 (de) * 1981-08-25 1987-01-15 Fried. Krupp Gmbh, 4300 Essen Verfahren zur Herstellung flüssiger Kohlenwasserstoffe durch katalytische Hydrierung von Kohle in Gegenwart von Wasser
US4946667A (en) * 1985-06-10 1990-08-07 Engelhard Corporation Method of steam reforming methanol to hydrogen
FR2622563B1 (fr) * 1987-10-29 1990-02-16 Azote & Prod Chim Procede de reformage de methanol impur et dispositif de mise en oeuvre
FR2631949B1 (fr) * 1988-05-27 1990-09-14 Inst Francais Du Petrole Procede de production d'hydrogene de haute purete par reformage catalytique du methanol
US5280701A (en) * 1992-08-31 1994-01-25 Environmental Energy Systems, Inc. Waste treatment system and method utilizing pressurized fluid
IT1272179B (it) * 1994-02-23 1997-06-16 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv.
IT1277914B1 (it) * 1995-08-22 1997-11-12 Angeletti P Ist Richerche Bio Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e
US5972077A (en) * 1996-02-15 1999-10-26 Lockheed Martin Energy Research Corporation Gas separation device based on electrical swing adsorption
DE69707361T2 (de) * 1996-06-06 2002-05-02 Mitsubishi Heavy Industries, Ltd. Verfahren und Apparat zur Konvertierung von Kunststoffabfällen in Öl
US6001256A (en) * 1996-09-25 1999-12-14 Energy & Environmental Research Center Method of manipulating the chemical properties of water to improve the effectiveness of a desired chemical process
US6352644B1 (en) * 1996-09-25 2002-03-05 Energy & Environmental Research Center Foundation Method of manipulating the chemical properties of water to improve the effectiveness of a desired process
US5912424A (en) * 1997-03-31 1999-06-15 Lockheed Martin Energy Research Corporation Electrical swing adsorption gas storage and delivery system
JPH11124400A (ja) * 1997-10-17 1999-05-11 Japan Energy Corp Ｃ型肝炎ウイルス由来セリンプロテアーゼ酵素アッセイ用基質ペプチド
US6251583B1 (en) * 1998-04-27 2001-06-26 Schering Corporation Peptide substrates for HCV NS3 protease assays
JP3057250B2 (ja) * 1998-11-18 2000-06-26 財団法人石炭利用総合センター 有機廃棄物の処理方法
DE10041577A1 (de) 2000-08-24 2002-03-14 Inst Technologie Der Kohlenhyd Verfahren zur Herstellung von Alkylglycosiden, insbesondere Alkylfructosiden
US6846806B2 (en) * 2000-10-23 2005-01-25 Bristol-Myers Squibb Company Peptide inhibitors of Hepatitis C virus NS3 protein
MXPA03004835A (es) * 2000-12-15 2005-04-19 Boehringer Ingelheim Ltd Proteasa ns2/3 activa, purificada de virus de hepatitis c.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08205893A (ja) * 1994-12-08 1996-08-13 Sumitomo Metal Ind Ltd Ｈｃｖプロテアーゼ活性測定法
JP2002530430A (ja) * 1998-11-26 2002-09-17 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Ｃ型肝炎ウイルスｎｓ３プロテアーゼ阻害用の医薬組成物
JP2003526361A (ja) * 2000-03-17 2003-09-09 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Ｈｃｖｎｓ２／３フラグメント及びその使用
JP2005523016A (ja) * 2002-04-19 2005-08-04 アマシャム・バイオサイエンス・コーポレイション 熱安定性ｄｎａポリメラーゼ及びその製造方法
WO2005073216A2 (en) * 2004-01-30 2005-08-11 Medivir Ab Hcv ns-3 serine protease inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012015499; Ｊ　Ｂｉｏｌ　Ｃｈｅｍ．，　２００５年８月，　第２８０巻，　２９６０４-２９６１１ページ *
JPN6012015500; Ｊ　Ｖｉｒｏｌ．，　２００１年，　第７５巻，　９９３９-９９４６ページ *

Also Published As

Publication number Publication date
WO2007048254A1 (en) 2007-05-03
EP1945797A1 (en) 2008-07-23
EP1945797B1 (en) 2012-05-30
ES2386462T3 (es) 2012-08-21
US7655394B2 (en) 2010-02-02
CA2627247A1 (en) 2007-05-03
US20070212754A1 (en) 2007-09-13
DK1945797T3 (da) 2012-08-06
EP1945797A4 (en) 2010-06-23
CA2627247C (en) 2013-04-02

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