ES2386462T3 - Ensayo de la actividad NS2/3 del virus de la hepatitis C - Google Patents
Ensayo de la actividad NS2/3 del virus de la hepatitis C Download PDFInfo
- Publication number
- ES2386462T3 ES2386462T3 ES06804656T ES06804656T ES2386462T3 ES 2386462 T3 ES2386462 T3 ES 2386462T3 ES 06804656 T ES06804656 T ES 06804656T ES 06804656 T ES06804656 T ES 06804656T ES 2386462 T3 ES2386462 T3 ES 2386462T3
- Authority
- ES
- Spain
- Prior art keywords
- protease
- substrate
- sec
- product
- assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73099905P | 2005-10-28 | 2005-10-28 | |
| US730999P | 2005-10-28 | ||
| PCT/CA2006/001773 WO2007048254A1 (en) | 2005-10-28 | 2006-10-27 | Hepatitis c virus ns2/3 activity assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2386462T3 true ES2386462T3 (es) | 2012-08-21 |
Family
ID=37967381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06804656T Active ES2386462T3 (es) | 2005-10-28 | 2006-10-27 | Ensayo de la actividad NS2/3 del virus de la hepatitis C |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7655394B2 (https=) |
| EP (1) | EP1945797B1 (https=) |
| JP (1) | JP2009513113A (https=) |
| CA (1) | CA2627247C (https=) |
| DK (1) | DK1945797T3 (https=) |
| ES (1) | ES2386462T3 (https=) |
| WO (1) | WO2007048254A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070141701A1 (en) * | 2005-12-21 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Hepatitis c virus ns2/3 assay |
| MX2009008439A (es) * | 2007-02-12 | 2009-08-13 | Intermune Inc | Nuevos inhibidores de la replicacion del virus de hepatitis c. |
| EA036483B1 (ru) * | 2012-11-12 | 2020-11-16 | Эпитоп Интернэшнл Нв | Пептиды, способные индуцировать толерантность к рекомбинантному fviii, содержащая их композиция, их применение и способ лечения гемофилии |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4372755A (en) * | 1978-07-27 | 1983-02-08 | Enrecon, Inc. | Production of a fuel gas with a stabilized metal carbide catalyst |
| DE3133562C2 (de) * | 1981-08-25 | 1987-01-15 | Fried. Krupp Gmbh, 4300 Essen | Verfahren zur Herstellung flüssiger Kohlenwasserstoffe durch katalytische Hydrierung von Kohle in Gegenwart von Wasser |
| US4946667A (en) * | 1985-06-10 | 1990-08-07 | Engelhard Corporation | Method of steam reforming methanol to hydrogen |
| FR2622563B1 (fr) * | 1987-10-29 | 1990-02-16 | Azote & Prod Chim | Procede de reformage de methanol impur et dispositif de mise en oeuvre |
| FR2631949B1 (fr) * | 1988-05-27 | 1990-09-14 | Inst Francais Du Petrole | Procede de production d'hydrogene de haute purete par reformage catalytique du methanol |
| US5280701A (en) * | 1992-08-31 | 1994-01-25 | Environmental Energy Systems, Inc. | Waste treatment system and method utilizing pressurized fluid |
| IT1272179B (it) * | 1994-02-23 | 1997-06-16 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv. |
| JPH08205893A (ja) * | 1994-12-08 | 1996-08-13 | Sumitomo Metal Ind Ltd | Ｈｃｖプロテアーゼ活性測定法 |
| IT1277914B1 (it) * | 1995-08-22 | 1997-11-12 | Angeletti P Ist Richerche Bio | Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e |
| US5972077A (en) * | 1996-02-15 | 1999-10-26 | Lockheed Martin Energy Research Corporation | Gas separation device based on electrical swing adsorption |
| DE69707361T2 (de) * | 1996-06-06 | 2002-05-02 | Mitsubishi Heavy Industries, Ltd. | Verfahren und Apparat zur Konvertierung von Kunststoffabfällen in Öl |
| US6001256A (en) * | 1996-09-25 | 1999-12-14 | Energy & Environmental Research Center | Method of manipulating the chemical properties of water to improve the effectiveness of a desired chemical process |
| US6352644B1 (en) * | 1996-09-25 | 2002-03-05 | Energy & Environmental Research Center Foundation | Method of manipulating the chemical properties of water to improve the effectiveness of a desired process |
| US5912424A (en) * | 1997-03-31 | 1999-06-15 | Lockheed Martin Energy Research Corporation | Electrical swing adsorption gas storage and delivery system |
| JPH11124400A (ja) * | 1997-10-17 | 1999-05-11 | Japan Energy Corp | Ｃ型肝炎ウイルス由来セリンプロテアーゼ酵素アッセイ用基質ペプチド |
| US6251583B1 (en) * | 1998-04-27 | 2001-06-26 | Schering Corporation | Peptide substrates for HCV NS3 protease assays |
| JP3057250B2 (ja) * | 1998-11-18 | 2000-06-26 | 財団法人石炭利用総合センター | 有機廃棄物の処理方法 |
| GB9825946D0 (en) * | 1998-11-26 | 1999-01-20 | Angeletti P Ist Richerche Bio | Pharmaceutical compounds for the inhibition of hepatitis C virus NS3 protease |
| GB0006537D0 (en) * | 2000-03-17 | 2000-05-10 | Angeletti P Ist Richerche Bio | Assays and screening methods |
| DE10041577A1 (de) | 2000-08-24 | 2002-03-14 | Inst Technologie Der Kohlenhyd | Verfahren zur Herstellung von Alkylglycosiden, insbesondere Alkylfructosiden |
| US6846806B2 (en) * | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
| MXPA03004835A (es) * | 2000-12-15 | 2005-04-19 | Boehringer Ingelheim Ltd | Proteasa ns2/3 activa, purificada de virus de hepatitis c. |
| US20030134292A1 (en) * | 2001-10-30 | 2003-07-17 | Farchaus Joseph W. | Thermostable DNA polymerases and methods of making same |
| JP4902361B2 (ja) * | 2004-01-30 | 2012-03-21 | メディヴィル・アクチエボラーグ | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
-
2006
- 2006-10-27 CA CA2627247A patent/CA2627247C/en not_active Expired - Fee Related
- 2006-10-27 WO PCT/CA2006/001773 patent/WO2007048254A1/en not_active Ceased
- 2006-10-27 EP EP06804656A patent/EP1945797B1/en not_active Not-in-force
- 2006-10-27 ES ES06804656T patent/ES2386462T3/es active Active
- 2006-10-27 JP JP2008536898A patent/JP2009513113A/ja active Pending
- 2006-10-27 US US11/553,531 patent/US7655394B2/en active Active
- 2006-10-27 DK DK06804656.4T patent/DK1945797T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009513113A (ja) | 2009-04-02 |
| WO2007048254A1 (en) | 2007-05-03 |
| EP1945797A1 (en) | 2008-07-23 |
| EP1945797B1 (en) | 2012-05-30 |
| US7655394B2 (en) | 2010-02-02 |
| CA2627247A1 (en) | 2007-05-03 |
| US20070212754A1 (en) | 2007-09-13 |
| DK1945797T3 (da) | 2012-08-06 |
| EP1945797A4 (en) | 2010-06-23 |
| CA2627247C (en) | 2013-04-02 |
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| US6251583B1 (en) | Peptide substrates for HCV NS3 protease assays | |
| ES2300262T3 (es) | Sistema basado en celulas sustitutivas y metodo ara analizar la actividad de la proteasa ns3 del virus de la hepatitis c. | |
| ES2386462T3 (es) | Ensayo de la actividad NS2/3 del virus de la hepatitis C | |
| JP3878132B2 (ja) | 精製活性型ｈｃｖｎｓ２／３プロテアーゼ | |
| Massariol et al. | Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3–NS4A proteins | |
| US8501426B2 (en) | Method for identifying protease inhibitors | |
| ES2317417T3 (es) | Ensayo del virus ns2/3 de la hepatitis c. | |
| AU2002224688B2 (en) | Purified active HCV NS2/3 protease | |
| Leary et al. | The Molecular Biology of GB Viruses | |
| JP2010502184A (ja) | プロテアーゼ阻害剤の同定方法 | |
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