JP2002541776A5 - - Google Patents
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- Publication number
- JP2002541776A5 JP2002541776A5 JP2000601144A JP2000601144A JP2002541776A5 JP 2002541776 A5 JP2002541776 A5 JP 2002541776A5 JP 2000601144 A JP2000601144 A JP 2000601144A JP 2000601144 A JP2000601144 A JP 2000601144A JP 2002541776 A5 JP2002541776 A5 JP 2002541776A5
- Authority
- JP
- Japan
- Prior art keywords
- phex
- sec
- endopeptidase
- homology
- chromosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2,262,056 | 1999-02-24 | ||
| CA002262056A CA2262056A1 (en) | 1999-02-24 | 1999-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human pex |
| PCT/CA2000/000201 WO2000050580A2 (en) | 1999-02-24 | 2000-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human phex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002541776A JP2002541776A (ja) | 2002-12-10 |
| JP2002541776A5 true JP2002541776A5 (https=) | 2007-03-15 |
Family
ID=4163297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000601144A Pending JP2002541776A (ja) | 1999-02-24 | 2000-02-24 | ヒトｐｈｅｘの可溶性形態の組成物、方法及び合成試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6790649B1 (https=) |
| EP (1) | EP1159412A2 (https=) |
| JP (1) | JP2002541776A (https=) |
| AU (1) | AU776042B2 (https=) |
| CA (1) | CA2262056A1 (https=) |
| WO (1) | WO2000050580A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001287429B2 (en) * | 2000-08-23 | 2005-08-18 | Alexion Pharmaceuticals, Inc. | Method and compositions for promoting osteogenesis |
| WO2002092128A1 (en) * | 2001-05-11 | 2002-11-21 | Genzyme Corporation | Compositions and methods to regulate serum phosphate |
| AU2003291867A1 (en) * | 2002-12-03 | 2004-06-23 | Biomep Inc. | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex |
| US20060292657A1 (en) * | 2003-03-26 | 2006-12-28 | Guy Boileau | Phex substrates and methods using same |
| CA2559228C (en) * | 2004-04-21 | 2016-06-21 | Enobia Pharma Inc. | Bone delivery conjugates and method of using same to target proteins to bone |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| BR112012027765A2 (pt) | 2010-04-30 | 2019-09-24 | Enobia Pharma Inc. | métodos, composições e kits para tratamento de distúrbios de mineralização da matriz. |
| WO2012088608A1 (en) | 2010-12-27 | 2012-07-05 | Enobia Canada Limited Partnership | Compositions comprising natriuretic peptides and methods of use thereof |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| MX389350B (es) | 2014-12-05 | 2025-03-19 | Alexion Pharma Inc | Fosfatasas alcalinas recombinantes y usos de las mismas para el tratamiento de convulsiones. |
| JP6868561B2 (ja) | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
| CN108350440A (zh) | 2015-08-17 | 2018-07-31 | 阿雷克森制药公司 | 碱性磷酸酯的制造 |
| JP6868617B2 (ja) | 2015-09-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 低ホスファターゼ血症の組織非特異的アルカリホスファターゼ（ｔｎｓａｌｐ）酵素補充療法に有効な投薬計画の特定 |
| JP2018533571A (ja) | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| WO2017155569A1 (en) | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| JP7613826B2 (ja) | 2016-04-01 | 2025-01-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼによって筋力低下を治療すること |
| US10988744B2 (en) | 2016-06-06 | 2021-04-27 | Alexion Pharmaceuticals, Inc. | Method of producing alkaline phosphatase |
| EP3500289B1 (en) | 2016-08-18 | 2024-10-09 | Alexion Pharmaceuticals, Inc. | Asfotase alfa for use in treating tracheobronchomalacia |
| EP3600383A4 (en) | 2017-03-31 | 2020-10-28 | Alexion Pharmaceuticals, Inc. | METHODS OF TREATMENT OF HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS |
| US11913039B2 (en) | 2018-03-30 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Method for producing recombinant alkaline phosphatase |
| US12268733B2 (en) | 2018-08-10 | 2025-04-08 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| CA3161266A1 (en) | 2019-12-09 | 2021-06-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| EP4130733B1 (en) * | 2020-03-27 | 2025-12-10 | Sekisui Medical Co., Ltd. | Liquid chromatography component |
| AU2021337652B2 (en) | 2020-09-04 | 2025-01-30 | Alexion Pharmaceuticals, Inc. | Methods for treating bone mineralization disorders |
| BR112023016048A2 (pt) | 2021-02-12 | 2023-11-14 | Alexion Pharma Inc | Polipeptídeos de fosfatase alcalina e métodos de uso dos mesmos |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840509A (en) * | 1996-07-22 | 1998-11-24 | Eli Lilly And Company | Protease and related nucleic acid compounds |
| WO1998010078A2 (en) * | 1996-09-05 | 1998-03-12 | Karaplis Andrew C | CLONING OF FULL-LENGTH HUMAN PEX cDNA |
-
1999
- 1999-02-24 CA CA002262056A patent/CA2262056A1/en not_active Abandoned
-
2000
- 2000-02-24 WO PCT/CA2000/000201 patent/WO2000050580A2/en not_active Ceased
- 2000-02-24 AU AU27900/00A patent/AU776042B2/en not_active Ceased
- 2000-02-24 JP JP2000601144A patent/JP2002541776A/ja active Pending
- 2000-02-24 EP EP00906114A patent/EP1159412A2/en not_active Withdrawn
- 2000-02-24 US US09/913,955 patent/US6790649B1/en not_active Expired - Lifetime
-
2004
- 2004-06-08 US US10/862,459 patent/US7427498B2/en not_active Expired - Fee Related
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