JP2009512837A5 - - Google Patents
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- Publication number
- JP2009512837A5 JP2009512837A5 JP2008533937A JP2008533937A JP2009512837A5 JP 2009512837 A5 JP2009512837 A5 JP 2009512837A5 JP 2008533937 A JP2008533937 A JP 2008533937A JP 2008533937 A JP2008533937 A JP 2008533937A JP 2009512837 A5 JP2009512837 A5 JP 2009512837A5
- Authority
- JP
- Japan
- Prior art keywords
- moiety
- fluorescent
- carboxyfluorescein
- acceptor
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- DCPHSBOTFHCNQC-UHFFFAOYSA-N 3',6'-dihydroxy-4',5'-dimethoxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylic acid Chemical compound O1C(=O)C2=CC=C(C(O)=O)C=C2C21C1=CC=C(O)C(OC)=C1OC1=C2C=CC(O)=C1OC DCPHSBOTFHCNQC-UHFFFAOYSA-N 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical group C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000011942 biocatalyst Substances 0.000 claims 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 2
- 150000008300 phosphoramidites Chemical class 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 238000002835 absorbance Methods 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 150000001993 dienes Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000007 visual effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72420205P | 2005-10-05 | 2005-10-05 | |
| US60/724,202 | 2005-10-05 | ||
| PCT/EP2006/009646 WO2007039301A2 (en) | 2005-10-05 | 2006-10-05 | Non-fluorescent energy transfer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009512837A JP2009512837A (ja) | 2009-03-26 |
| JP2009512837A5 true JP2009512837A5 (https=) | 2009-09-03 |
| JP4843044B2 JP4843044B2 (ja) | 2011-12-21 |
Family
ID=37574999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533937A Expired - Fee Related JP4843044B2 (ja) | 2005-10-05 | 2006-10-05 | 非蛍光性エネルギー移動 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7741467B2 (https=) |
| EP (1) | EP1934374B1 (https=) |
| JP (1) | JP4843044B2 (https=) |
| CN (1) | CN101321878B (https=) |
| AT (1) | ATE519863T1 (https=) |
| CA (1) | CA2624917C (https=) |
| ES (1) | ES2371088T3 (https=) |
| WO (1) | WO2007039301A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| FI20070163A0 (fi) * | 2007-02-27 | 2007-02-27 | Hidex Oy | Parannettu homogeeninen luminesenssibiotesti |
| JP2010525333A (ja) * | 2007-04-18 | 2010-07-22 | ベクトン・ディキンソン・アンド・カンパニー | Ｓｅｒｓナノタグを用いる分析法 |
| US8206929B2 (en) * | 2009-01-07 | 2012-06-26 | Roche Molecular Systems, Inc. | Nucleic acid amplification with allele-specific suppression of sequence variants |
| EP2398868B1 (en) * | 2009-02-20 | 2016-06-15 | Perkinelmer Biosignal, Inc. | Multiplex assay methods and compositions |
| WO2010101947A2 (en) * | 2009-03-02 | 2010-09-10 | Cooperative Diagnostics, Llc | Rapid oligo probes |
| US8674080B2 (en) | 2009-04-09 | 2014-03-18 | Roche Molecular Systems, Inc. | Dye composition for liquid transfer control |
| EP3209798B1 (en) * | 2014-10-23 | 2022-07-27 | Ricardo Mancebo | Reagents and methods for isothermal chain reaction |
| US9745618B2 (en) | 2014-11-19 | 2017-08-29 | Roche Molecular Systems, Inc. | Photoblocked probes and methods for sequential detection of nucleic acids |
| US9920381B2 (en) | 2014-12-02 | 2018-03-20 | Roche Molecular Systems, Inc. | Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus |
| WO2017153566A1 (en) | 2016-03-11 | 2017-09-14 | Roche Diagnostics Gmbh | Compositions and methods for detection of zika virus |
| CN109154023B (zh) | 2016-05-27 | 2022-09-20 | 豪夫迈·罗氏有限公司 | 用于检测阴道毛滴虫的组合物和方法 |
| US10612101B2 (en) | 2016-05-27 | 2020-04-07 | Roche Molecular Systems, Inc. | Compositions and methods for detection of Mycoplasma genitalium |
| EP4645615A3 (en) * | 2016-06-03 | 2026-01-28 | The General Hospital Corporation | System and method for micro laser particles |
| IL291323B2 (en) | 2016-07-15 | 2023-09-01 | Am Chemicals Llc | Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis |
| JP7483373B2 (ja) | 2016-07-29 | 2024-05-15 | ジュノー セラピューティクス インコーポレイテッド | 複製可能ウイルスの存在または非存在を評価するための方法 |
| ES3008759T3 (en) | 2016-08-02 | 2025-03-25 | Hoffmann La Roche | Helper oligonucleotide for improving efficiency of amplification and detection/quantitation of nucleic acids |
| US10793923B2 (en) | 2016-11-09 | 2020-10-06 | Roche Molecular Systems, Inc. | Compositions and methods for detection of BK virus |
| US10760137B2 (en) | 2017-07-18 | 2020-09-01 | Roche Molecular Systems, Inc. | Compositions and methods for detection of Babesia |
| WO2019063661A1 (en) | 2017-09-29 | 2019-04-04 | Roche Diagnostics Gmbh | COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS |
| US11535903B2 (en) | 2018-01-31 | 2022-12-27 | Juno Therapeutics, Inc. | Methods and reagents for assessing the presence or absence of replication competent virus |
| US11604186B2 (en) * | 2018-10-17 | 2023-03-14 | Molecular Devices (Austria) GmbH | Real time western blot assays utilizing fluorescence resonance energy transfer (FRET) |
| JP7478734B2 (ja) | 2018-12-03 | 2024-05-07 | エフ． ホフマン－ラ ロシュ アーゲー | カンジダ・アウリス（ｃａｎｄｉｄａ ａｕｒｉｓ）の検出のための組成物および方法 |
| JP7628085B2 (ja) | 2019-05-02 | 2025-02-07 | エフ． ホフマン－ラ ロシュ アーゲー | 鎖分離温度に基づくＤＮＡに対してＲＮＡ標的の優先的／選択的増幅のためのｄＩＴＰの利用 |
| WO2020225231A1 (en) | 2019-05-07 | 2020-11-12 | F. Hoffmann-La Roche Ag | Compositions and methods for detection of neisseria gonorroheae |
| WO2021013972A1 (en) | 2019-07-25 | 2021-01-28 | F. Hoffmann-La Roche Ag | Compositions and methods for detection of epstein barr virus (ebv) |
| JP7677950B2 (ja) | 2019-08-27 | 2025-05-15 | エフ． ホフマン－ラ ロシュ アーゲー | ｃｃｃＤＮＡから転写されたＨＢＶ ＲＮＡを含む、Ｂ型肝炎ウイルスＲＮＡの増幅および検出のための組成物および方法 |
| US11441167B2 (en) | 2019-11-20 | 2022-09-13 | Roche Molecular Systems, Inc. | Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi |
| ES2991814T3 (es) | 2019-12-27 | 2024-12-05 | Hoffmann La Roche | Composiciones y procedimientos para detectar Staphylococcus aureus resistente a la meticilina |
| US20220356537A1 (en) | 2019-12-31 | 2022-11-10 | Roche Molecular Systems, Inc. | Quantitative pcr screening of inducible prophage from bacterial isolates |
| CA3166337A1 (en) | 2020-03-09 | 2021-09-16 | F. Hoffmann-La Roche Ag | Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2), influenza a and influenza b |
| US20220042117A1 (en) | 2020-08-06 | 2022-02-10 | Roche Molecular Systems, Inc. | COMPOSITIONS AND METHODS FOR THE SIMULTANEOUS DETECTION OF INFLUENZA A, INFLUENZA B, AND SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2) |
| CN112630198A (zh) * | 2020-09-15 | 2021-04-09 | 北京工业大学 | 一种基于回音壁模式光学微腔的传感检测方法 |
| EP4256089A1 (en) | 2020-12-04 | 2023-10-11 | F. Hoffmann-La Roche AG | Compositions and methods for detection of malaria |
| US20220205020A1 (en) | 2020-12-30 | 2022-06-30 | Roche Molecular Systems, Inc. | Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis |
| JP2024505686A (ja) | 2021-02-05 | 2024-02-07 | エフ． ホフマン－ラ ロシュ アーゲー | ヒトパラインフルエンザウイルス１－４（ｈｐｉｖ１－４）の検出のための組成物及び方法 |
| US20220290221A1 (en) | 2021-03-15 | 2022-09-15 | Roche Molecular Systems, Inc. | Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations |
| US20240240273A1 (en) | 2021-05-06 | 2024-07-18 | Roche Molecular Systems, Inc. | Compositions and Methods for Detecting Hepatitis Delta Virus by a Dual-Target Assay |
| CN118202069A (zh) | 2021-11-05 | 2024-06-14 | 豪夫迈·罗氏有限公司 | 用于检测疟疾的组合物和方法 |
| EP4437142A1 (en) | 2021-11-22 | 2024-10-02 | F. Hoffmann-La Roche AG | Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance |
| JP2025500496A (ja) | 2021-12-24 | 2025-01-09 | エフ． ホフマン－ラ ロシュ アーゲー | Ｌａｍｐ増幅産物の改良された検出 |
| US20260098309A1 (en) | 2022-06-30 | 2026-04-09 | Roche Molecular Systems, Inc. | Compositions and methods for detecting lymphogranuloma venereum (lgv) serovars of chlamydia trachomatis |
| US20260055475A1 (en) | 2022-08-24 | 2026-02-26 | Roche Molecular Systems, Inc. | Compositions and methods for detecting monkeypox virus |
| WO2024141442A1 (en) | 2022-12-25 | 2024-07-04 | F. Hoffmann-La Roche Ag | Compositions and methods for detecting carbapenem resistant acinetobacter calcoaceticus-baumannii (crab) |
| JP2026502046A (ja) | 2022-12-28 | 2026-01-21 | エフ． ホフマン－ラ ロシュ アーゲー | 複数のｂ型肝炎ウイルス遺伝子標的のためのデジタルｐｃｒアッセイ設計およびそのための非伸長性ブロッカーオリゴヌクレオチド |
| EP4669777A1 (en) | 2023-02-25 | 2025-12-31 | F. Hoffmann-La Roche AG | COMPOSITIONS AND METHODS FOR DETECTION OF CANDIDA SPECIES |
| EP4677114A1 (en) | 2023-03-03 | 2026-01-14 | F. Hoffmann-La Roche AG | Compositions and methods for the detection of group b streptococcus( streptococcus agalactiae) and clindamycin resistance gene determinants |
| CN121889512A (zh) | 2023-08-03 | 2026-04-17 | 罗氏测序解决方案公司 | 使用5'加尾长引物来改善靶向短引物结合位点时的扩增性能 |
| WO2025202488A1 (en) | 2024-03-28 | 2025-10-02 | Roche Diagnostics Gmbh | Enhancer of nucleic acid amplification |
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| US4318846A (en) * | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| DE3071373D1 (en) | 1980-10-27 | 1986-03-06 | Syva Co | Novel ether substituted fluorescein compounds as fluorescers and quenchers |
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| US5654419A (en) * | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| US6028190A (en) * | 1994-02-01 | 2000-02-22 | The Regents Of The University Of California | Probes labeled with energy transfer coupled dyes |
| WO1995030139A1 (en) * | 1994-04-29 | 1995-11-09 | Perkin-Elmer Corporation | System for real time detection of nucleic acid amplification products |
| US5863727A (en) * | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
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| US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5853992A (en) * | 1996-10-04 | 1998-12-29 | The Regents Of The University Of California | Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels |
| US6365346B1 (en) * | 1998-02-18 | 2002-04-02 | Dade Behring Inc. | Quantitative determination of nucleic acid amplification products |
| US6768000B1 (en) * | 1998-06-12 | 2004-07-27 | Intergen Company | Multi-fluorescent hairpin energy transfer oligonucleotides |
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| US20040197793A1 (en) * | 2002-08-30 | 2004-10-07 | Arjang Hassibi | Methods and apparatus for biomolecule detection, identification, quantification and/or sequencing |
| US20050118619A1 (en) * | 2003-09-22 | 2005-06-02 | Wensheng Xia | Dark quenchers for fluorescence resonance energy transfer (FRET) in bioassays |
| KR101244759B1 (ko) | 2004-06-18 | 2013-03-19 | 엑손모빌 업스트림 리서치 캄파니 | 확장형 용량의 액화 천연 가스 플랜트 |
-
2006
- 2006-10-05 WO PCT/EP2006/009646 patent/WO2007039301A2/en not_active Ceased
- 2006-10-05 US US11/544,460 patent/US7741467B2/en not_active Expired - Fee Related
- 2006-10-05 AT AT06806056T patent/ATE519863T1/de active
- 2006-10-05 ES ES06806056T patent/ES2371088T3/es active Active
- 2006-10-05 CN CN200680045298.1A patent/CN101321878B/zh not_active Expired - Fee Related
- 2006-10-05 EP EP06806056A patent/EP1934374B1/en not_active Not-in-force
- 2006-10-05 JP JP2008533937A patent/JP4843044B2/ja not_active Expired - Fee Related
- 2006-10-05 CA CA2624917A patent/CA2624917C/en not_active Expired - Fee Related
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