JP2009511551A - 心房細動の治療のための化合物 - Google Patents

心房細動の治療のための化合物 Download PDF

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JP2009511551A
JP2009511551A JP2008535047A JP2008535047A JP2009511551A JP 2009511551 A JP2009511551 A JP 2009511551A JP 2008535047 A JP2008535047 A JP 2008535047A JP 2008535047 A JP2008535047 A JP 2008535047A JP 2009511551 A JP2009511551 A JP 2009511551A
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receptor
atrial fibrillation
antagonist
atrial
calcium
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Japanese (ja)
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JP2009511551A5 (enExample
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ラファエル、フランコ、フェルナンデス
フランシスコ、シルエラ、アルフェレス
カルメン、リュイス、ビセット
クリスタ、ミュラー
ホアン、シンカ、クスクジョラ
レイフ、オベ‐マデセン
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Proyecto de Biomedicina CIMA SL
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Proyecto de Biomedicina CIMA SL
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Publication of JP2009511551A publication Critical patent/JP2009511551A/ja
Publication of JP2009511551A5 publication Critical patent/JP2009511551A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
JP2008535047A 2005-10-14 2006-10-10 心房細動の治療のための化合物 Pending JP2009511551A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200502545A ES2273599B1 (es) 2005-10-14 2005-10-14 Compuestos para el tratamiento de la fibrilacion auricular.
PCT/ES2006/000564 WO2007045705A2 (es) 2005-10-14 2006-10-10 Compuestos para el tratamiento de la fibrilación auricular

Publications (2)

Publication Number Publication Date
JP2009511551A true JP2009511551A (ja) 2009-03-19
JP2009511551A5 JP2009511551A5 (enExample) 2009-11-26

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Family Applications (1)

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JP2008535047A Pending JP2009511551A (ja) 2005-10-14 2006-10-10 心房細動の治療のための化合物

Country Status (13)

Country Link
US (1) US8012973B2 (enExample)
EP (1) EP1949903B8 (enExample)
JP (1) JP2009511551A (enExample)
CN (1) CN101325956B (enExample)
AT (1) ATE553763T1 (enExample)
AU (1) AU2006303240B2 (enExample)
BR (1) BRPI0617369A2 (enExample)
CA (1) CA2626020A1 (enExample)
DK (1) DK1949903T3 (enExample)
ES (2) ES2273599B1 (enExample)
MX (1) MX2008004886A (enExample)
RU (1) RU2445099C2 (enExample)
WO (1) WO2007045705A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020519564A (ja) * 2017-03-07 2020-07-02 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド アミノピリミジン縮合5員複素環化合物、その中間体、製造方法、薬物組成物および使用
KR20230004995A (ko) * 2021-06-30 2023-01-09 단국대학교 천안캠퍼스 산학협력단 인간치아줄기세포의 상아모세포로의 분화를 위한 신규 화합물 및 이의 의학적 용도

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3088900B1 (en) * 2011-10-17 2020-08-12 Roche Diagniostics GmbH Troponin as marker for intermittent atrial fibrillation
CZ2014307A3 (cs) * 2014-05-06 2016-01-13 Vysoká škola chemicko- technologická v Praze Kofein-8-hydrazony jako nová cytostatika pro léčbu onkologických onemocnění
WO2017008205A1 (en) * 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
JP7478673B2 (ja) 2018-06-04 2024-05-07 エクスシエンティア・エルティーディー アデノシン受容体アンタゴニストとしてのピラゾロピリミジン化合物
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
EP4146341A4 (en) * 2020-05-06 2024-06-26 Ohio State Innovation Foundation Compositions and methods for treating atrial fibrillation

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JP2005515980A (ja) * 2001-11-19 2005-06-02 エフ.ホフマン−ラ ロシュ アーゲー アデノシン受容体リガンドとしてのベンゾチアゾール誘導体

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020519564A (ja) * 2017-03-07 2020-07-02 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド アミノピリミジン縮合5員複素環化合物、その中間体、製造方法、薬物組成物および使用
JP7071389B2 (ja) 2017-03-07 2022-05-18 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド アミノピリミジン縮合5員複素環化合物、その中間体、製造方法、薬物組成物および使用
KR20230004995A (ko) * 2021-06-30 2023-01-09 단국대학교 천안캠퍼스 산학협력단 인간치아줄기세포의 상아모세포로의 분화를 위한 신규 화합물 및 이의 의학적 용도
KR102675647B1 (ko) * 2021-06-30 2024-06-18 단국대학교 천안캠퍼스 산학협력단 인간치아줄기세포의 상아모세포로의 분화를 위한 신규 화합물 및 이의 의학적 용도

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Publication number Publication date
CN101325956B (zh) 2012-02-29
AU2006303240A1 (en) 2007-04-26
ATE553763T1 (de) 2012-05-15
ES2273599A1 (es) 2007-05-01
US20090312332A1 (en) 2009-12-17
EP1949903B1 (en) 2012-04-18
AU2006303240B2 (en) 2012-07-12
CA2626020A1 (en) 2007-04-26
RU2445099C2 (ru) 2012-03-20
CN101325956A (zh) 2008-12-17
ES2273599B1 (es) 2008-06-01
EP1949903B8 (en) 2012-05-23
ES2386377T3 (es) 2012-08-20
MX2008004886A (es) 2009-03-02
BRPI0617369A2 (pt) 2011-07-26
US8012973B2 (en) 2011-09-06
RU2008118995A (ru) 2009-11-20
WO2007045705A2 (es) 2007-04-26
DK1949903T3 (da) 2012-07-30
EP1949903A2 (en) 2008-07-30
WO2007045705A3 (es) 2007-06-14

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