AU2006303240B2 - Compounds for the treatment of atrial fibrillation - Google Patents

Compounds for the treatment of atrial fibrillation Download PDF

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Publication number
AU2006303240B2
AU2006303240B2 AU2006303240A AU2006303240A AU2006303240B2 AU 2006303240 B2 AU2006303240 B2 AU 2006303240B2 AU 2006303240 A AU2006303240 A AU 2006303240A AU 2006303240 A AU2006303240 A AU 2006303240A AU 2006303240 B2 AU2006303240 B2 AU 2006303240B2
Authority
AU
Australia
Prior art keywords
receptor
receptor antagonist
selective adenosine
adenosine
atrial fibrillation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006303240A
Other languages
English (en)
Other versions
AU2006303240A1 (en
Inventor
Joan Cinca Cuscullola
Francisco Ciruela Alferez
Rafael Franco Fernandez
Leif Hove-Madsen
Carmen Lluis Biset
Christa Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proyecto de Biomedicina CIMA SL
Original Assignee
Proyecto de Biomedicina CIMA SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proyecto de Biomedicina CIMA SL filed Critical Proyecto de Biomedicina CIMA SL
Publication of AU2006303240A1 publication Critical patent/AU2006303240A1/en
Application granted granted Critical
Publication of AU2006303240B2 publication Critical patent/AU2006303240B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
AU2006303240A 2005-10-14 2006-10-10 Compounds for the treatment of atrial fibrillation Ceased AU2006303240B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200502545 2005-10-14
ES200502545A ES2273599B1 (es) 2005-10-14 2005-10-14 Compuestos para el tratamiento de la fibrilacion auricular.
PCT/ES2006/000564 WO2007045705A2 (es) 2005-10-14 2006-10-10 Compuestos para el tratamiento de la fibrilación auricular

Publications (2)

Publication Number Publication Date
AU2006303240A1 AU2006303240A1 (en) 2007-04-26
AU2006303240B2 true AU2006303240B2 (en) 2012-07-12

Family

ID=37962872

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006303240A Ceased AU2006303240B2 (en) 2005-10-14 2006-10-10 Compounds for the treatment of atrial fibrillation

Country Status (13)

Country Link
US (1) US8012973B2 (enExample)
EP (1) EP1949903B8 (enExample)
JP (1) JP2009511551A (enExample)
CN (1) CN101325956B (enExample)
AT (1) ATE553763T1 (enExample)
AU (1) AU2006303240B2 (enExample)
BR (1) BRPI0617369A2 (enExample)
CA (1) CA2626020A1 (enExample)
DK (1) DK1949903T3 (enExample)
ES (2) ES2273599B1 (enExample)
MX (1) MX2008004886A (enExample)
RU (1) RU2445099C2 (enExample)
WO (1) WO2007045705A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3088900B1 (en) * 2011-10-17 2020-08-12 Roche Diagniostics GmbH Troponin as marker for intermittent atrial fibrillation
CZ2014307A3 (cs) * 2014-05-06 2016-01-13 Vysoká škola chemicko- technologická v Praze Kofein-8-hydrazony jako nová cytostatika pro léčbu onkologických onemocnění
WO2017008205A1 (en) * 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
CN108570054B (zh) * 2017-03-07 2021-07-16 广州再极医药科技有限公司 氨基嘧啶并五元杂环化合物、其中间体、制备方法、药物组合物及应用
JP7478673B2 (ja) 2018-06-04 2024-05-07 エクスシエンティア・エルティーディー アデノシン受容体アンタゴニストとしてのピラゾロピリミジン化合物
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
EP4146341A4 (en) * 2020-05-06 2024-06-26 Ohio State Innovation Foundation Compositions and methods for treating atrial fibrillation
KR102675647B1 (ko) * 2021-06-30 2024-06-18 단국대학교 천안캠퍼스 산학협력단 인간치아줄기세포의 상아모세포로의 분화를 위한 신규 화합물 및 이의 의학적 용도

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Also Published As

Publication number Publication date
CN101325956B (zh) 2012-02-29
AU2006303240A1 (en) 2007-04-26
ATE553763T1 (de) 2012-05-15
ES2273599A1 (es) 2007-05-01
US20090312332A1 (en) 2009-12-17
EP1949903B1 (en) 2012-04-18
CA2626020A1 (en) 2007-04-26
RU2445099C2 (ru) 2012-03-20
CN101325956A (zh) 2008-12-17
ES2273599B1 (es) 2008-06-01
EP1949903B8 (en) 2012-05-23
ES2386377T3 (es) 2012-08-20
MX2008004886A (es) 2009-03-02
BRPI0617369A2 (pt) 2011-07-26
US8012973B2 (en) 2011-09-06
RU2008118995A (ru) 2009-11-20
JP2009511551A (ja) 2009-03-19
WO2007045705A2 (es) 2007-04-26
DK1949903T3 (da) 2012-07-30
EP1949903A2 (en) 2008-07-30
WO2007045705A3 (es) 2007-06-14

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