CN101325956B - 治疗心房颤动的化合物 - Google Patents

治疗心房颤动的化合物 Download PDF

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Publication number
CN101325956B
CN101325956B CN200680046601XA CN200680046601A CN101325956B CN 101325956 B CN101325956 B CN 101325956B CN 200680046601X A CN200680046601X A CN 200680046601XA CN 200680046601 A CN200680046601 A CN 200680046601A CN 101325956 B CN101325956 B CN 101325956B
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receptor
adenosine
atrial fibrillation
calcium
antagonists
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Expired - Fee Related
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CN101325956A (zh
Inventor
拉斐尔·弗朗克费尔南德兹
弗朗西斯科·斯如拉阿尔费瑞兹
卡门·路易斯比萨特
克里斯塔·穆勒
让·辛卡库斯库洛拉
雷夫·浩乌-马德森
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Proyecto de Biomedicina CIMA SL
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Proyecto de Biomedicina CIMA SL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN200680046601XA 2005-10-14 2006-10-10 治疗心房颤动的化合物 Expired - Fee Related CN101325956B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200502545 2005-10-14
ES200502545A ES2273599B1 (es) 2005-10-14 2005-10-14 Compuestos para el tratamiento de la fibrilacion auricular.
PCT/ES2006/000564 WO2007045705A2 (es) 2005-10-14 2006-10-10 Compuestos para el tratamiento de la fibrilación auricular

Publications (2)

Publication Number Publication Date
CN101325956A CN101325956A (zh) 2008-12-17
CN101325956B true CN101325956B (zh) 2012-02-29

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CN200680046601XA Expired - Fee Related CN101325956B (zh) 2005-10-14 2006-10-10 治疗心房颤动的化合物

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Country Link
US (1) US8012973B2 (enExample)
EP (1) EP1949903B8 (enExample)
JP (1) JP2009511551A (enExample)
CN (1) CN101325956B (enExample)
AT (1) ATE553763T1 (enExample)
AU (1) AU2006303240B2 (enExample)
BR (1) BRPI0617369A2 (enExample)
CA (1) CA2626020A1 (enExample)
DK (1) DK1949903T3 (enExample)
ES (2) ES2273599B1 (enExample)
MX (1) MX2008004886A (enExample)
RU (1) RU2445099C2 (enExample)
WO (1) WO2007045705A2 (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
EP3088900B1 (en) * 2011-10-17 2020-08-12 Roche Diagniostics GmbH Troponin as marker for intermittent atrial fibrillation
CZ2014307A3 (cs) * 2014-05-06 2016-01-13 Vysoká škola chemicko- technologická v Praze Kofein-8-hydrazony jako nová cytostatika pro léčbu onkologických onemocnění
WO2017008205A1 (en) * 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Substituted aminoquinazoline compounds as a2a antagonist
CN108570054B (zh) * 2017-03-07 2021-07-16 广州再极医药科技有限公司 氨基嘧啶并五元杂环化合物、其中间体、制备方法、药物组合物及应用
JP7478673B2 (ja) 2018-06-04 2024-05-07 エクスシエンティア・エルティーディー アデノシン受容体アンタゴニストとしてのピラゾロピリミジン化合物
CN108864114B (zh) * 2018-06-04 2020-11-06 应世生物科技(南京)有限公司 选择性a2a受体拮抗剂
EP4146341A4 (en) * 2020-05-06 2024-06-26 Ohio State Innovation Foundation Compositions and methods for treating atrial fibrillation
KR102675647B1 (ko) * 2021-06-30 2024-06-18 단국대학교 천안캠퍼스 산학협력단 인간치아줄기세포의 상아모세포로의 분화를 위한 신규 화합물 및 이의 의학적 용도

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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
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US4772607A (en) * 1986-05-20 1988-09-20 Warner-Lambert Company Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor
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Also Published As

Publication number Publication date
AU2006303240A1 (en) 2007-04-26
ATE553763T1 (de) 2012-05-15
ES2273599A1 (es) 2007-05-01
US20090312332A1 (en) 2009-12-17
EP1949903B1 (en) 2012-04-18
AU2006303240B2 (en) 2012-07-12
CA2626020A1 (en) 2007-04-26
RU2445099C2 (ru) 2012-03-20
CN101325956A (zh) 2008-12-17
ES2273599B1 (es) 2008-06-01
EP1949903B8 (en) 2012-05-23
ES2386377T3 (es) 2012-08-20
MX2008004886A (es) 2009-03-02
BRPI0617369A2 (pt) 2011-07-26
US8012973B2 (en) 2011-09-06
RU2008118995A (ru) 2009-11-20
JP2009511551A (ja) 2009-03-19
WO2007045705A2 (es) 2007-04-26
DK1949903T3 (da) 2012-07-30
EP1949903A2 (en) 2008-07-30
WO2007045705A3 (es) 2007-06-14

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