JP2009510462A5 - - Google Patents
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- Publication number
- JP2009510462A5 JP2009510462A5 JP2008533849A JP2008533849A JP2009510462A5 JP 2009510462 A5 JP2009510462 A5 JP 2009510462A5 JP 2008533849 A JP2008533849 A JP 2008533849A JP 2008533849 A JP2008533849 A JP 2008533849A JP 2009510462 A5 JP2009510462 A5 JP 2009510462A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- cycloalkenyl
- cycloalkyl
- cycloalkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000001875 compounds Chemical class 0.000 claims 35
- 125000001072 heteroaryl group Chemical group 0.000 claims 35
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000003118 aryl group Chemical group 0.000 claims 31
- -1 cycloalkynyl Chemical group 0.000 claims 24
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims 21
- 125000000623 heterocyclic group Chemical group 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 125000003342 alkenyl group Chemical group 0.000 claims 16
- 239000004721 Polyphenylene oxide Substances 0.000 claims 14
- 125000002877 alkyl aryl group Chemical group 0.000 claims 14
- 229920000570 polyether Polymers 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 150000007942 carboxylates Chemical class 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- SVSARCCKBMZNMR-UHFFFAOYSA-N [1-[2-[methyl-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethyl]amino]ethyl]pyridin-4-ylidene]methyl-oxoazanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1CCN(C)CCN1C=CC(=C[NH+]=O)C=C1 SVSARCCKBMZNMR-UHFFFAOYSA-N 0.000 claims 5
- CMFNMSMUKZHDEY-UHFFFAOYSA-N peroxynitrous acid Chemical compound OON=O CMFNMSMUKZHDEY-UHFFFAOYSA-N 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 229930194542 Keto Natural products 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000000468 ketone group Chemical group 0.000 claims 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 3
- 150000001408 amides Chemical group 0.000 claims 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 3
- 150000002485 inorganic esters Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 150000003573 thiols Chemical class 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- NNRXCKZMQLFUPL-WBMZRJHASA-N (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;(2r,3 Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 NNRXCKZMQLFUPL-WBMZRJHASA-N 0.000 claims 1
- VGIRNWJSIRVFRT-UHFFFAOYSA-N 2',7'-difluorofluorescein Chemical compound OC(=O)C1=CC=CC=C1C1=C2C=C(F)C(=O)C=C2OC2=CC(O)=C(F)C=C21 VGIRNWJSIRVFRT-UHFFFAOYSA-N 0.000 claims 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 claims 1
- QCPFFGGFHNZBEP-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 QCPFFGGFHNZBEP-UHFFFAOYSA-N 0.000 claims 1
- IDLISIVVYLGCKO-UHFFFAOYSA-N 6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein Chemical compound O1C(=O)C2=CC=C(C(O)=O)C=C2C21C1=CC(OC)=C(O)C(Cl)=C1OC1=C2C=C(OC)C(O)=C1Cl IDLISIVVYLGCKO-UHFFFAOYSA-N 0.000 claims 1
- BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 claims 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 1
- 108010053210 Phycocyanin Proteins 0.000 claims 1
- 108010004729 Phycoerythrin Proteins 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical group C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 claims 1
- 108010004469 allophycocyanin Proteins 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 125000005577 anthracene group Chemical group 0.000 claims 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 claims 1
- 229940098008 erythrocin Drugs 0.000 claims 1
- ZFKJVJIDPQDDFY-UHFFFAOYSA-N fluorescamine Chemical compound C12=CC=CC=C2C(=O)OC1(C1=O)OC=C1C1=CC=CC=C1 ZFKJVJIDPQDDFY-UHFFFAOYSA-N 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 150000002390 heteroarenes Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 claims 1
- WGTODYJZXSJIAG-UHFFFAOYSA-N tetramethylrhodamine chloride Chemical compound [Cl-].C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C(O)=O WGTODYJZXSJIAG-UHFFFAOYSA-N 0.000 claims 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/245,529 US7705040B2 (en) | 2005-10-07 | 2005-10-07 | Reagents for highly specific detection of peroxynitrite |
| PCT/CN2006/002177 WO2007041923A1 (en) | 2005-10-07 | 2006-08-25 | Reagents for highly specific detection of peroxynitrite |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009510462A JP2009510462A (ja) | 2009-03-12 |
| JP2009510462A5 true JP2009510462A5 (enExample) | 2009-10-01 |
Family
ID=37911450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533849A Abandoned JP2009510462A (ja) | 2005-10-07 | 2006-08-25 | ペルオキシナイトライトの高特異的検出のための試薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7705040B2 (enExample) |
| EP (1) | EP1943254A4 (enExample) |
| JP (1) | JP2009510462A (enExample) |
| CN (1) | CN101321767B (enExample) |
| AU (1) | AU2006301818A1 (enExample) |
| CA (1) | CA2624598A1 (enExample) |
| WO (1) | WO2007041923A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5228190B2 (ja) * | 2005-11-14 | 2013-07-03 | 国立大学法人 東京大学 | パーオキシナイトライト蛍光プローブ |
| US7858598B2 (en) * | 2007-03-12 | 2010-12-28 | Morningside Ventures Limited & Versitech Limited | Reagents for detection of hypochlorous acid |
| JPWO2009107769A1 (ja) * | 2008-02-29 | 2011-07-07 | 国立大学法人 東京大学 | 活性酸素測定用試薬 |
| US20110004203A1 (en) * | 2009-07-01 | 2011-01-06 | Ralph Zipper | Laser Device and Method for Decreasing the Size and/or Changing the Shape of Pelvic Tissues |
| US10743929B2 (en) * | 2009-07-01 | 2020-08-18 | Ralph Zipper | Bulbous tipped surgical device and method for decreasing the size and/or changing the shape of pelvic tissues |
| US8795264B2 (en) * | 2008-07-01 | 2014-08-05 | Ralph Zipper | Method for decreasing the size and/or changing the shape of pelvic tissues |
| US20100081159A1 (en) * | 2008-09-26 | 2010-04-01 | Lebedeva Irina V | Profiling reactive oxygen, nitrogen and halogen species |
| WO2012047212A1 (en) * | 2010-10-06 | 2012-04-12 | Hewlett-Packard Development Company, L.P. | Modified bodipy dye matrix |
| KR101174585B1 (ko) | 2011-04-11 | 2012-08-16 | 부산대학교 산학협력단 | 퍼옥시니트리트 검출용 바이오센서 및 이를 이용한 퍼옥시니트리트 검출방법 |
| CN102702768B (zh) * | 2012-06-04 | 2013-12-04 | 天津理工大学 | 一种新型红光bodipy荧光染料及其制备方法和应用 |
| CN102898858B (zh) * | 2012-10-19 | 2014-10-01 | 中国乐凯集团有限公司 | 一种3',6'-二甲氧基荧烷黄热敏染料的制备方法 |
| EP2948462A2 (en) * | 2013-01-28 | 2015-12-02 | Council of Scientific & Industrial Research | A novel aza bodipy compound for the selective detection of nitrite ions in water and a process for preparation thereof |
| CN103145685B (zh) * | 2013-03-20 | 2014-10-29 | 大连理工大学 | 一类荧光化合物和其在检测钌中的应用 |
| CN103342720B (zh) * | 2013-07-01 | 2015-08-26 | 南京大学 | 近红外bodipy类的羟基自由基探针及其合成方法和用途 |
| HU231175B1 (hu) * | 2015-12-04 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával |
| GB2551567A (en) * | 2016-06-23 | 2017-12-27 | Sumitomo Chemical Co | Method, composition and sensor |
| CN108732299B (zh) * | 2018-06-01 | 2020-10-16 | 遵义医科大学 | 水质中亚硝酸盐的比色检测方法 |
| JP2021155362A (ja) * | 2020-03-27 | 2021-10-07 | 株式会社ナリス化粧品 | ペルオキシナイトライト活性阻害方法および、ペルオキシナイトライト活性阻害剤のスクリーニング方法 |
| CN114853779B (zh) * | 2022-06-09 | 2023-11-10 | 南京工业大学 | 细胞及生物体内生物硫醇检测与特异性快速标记巯基蛋白质的荧光探针、制备方法及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0654311B2 (ja) * | 1986-10-28 | 1994-07-20 | コニカ株式会社 | 亜硝酸イオンによる口臭測定用分析素子 |
| US5185129A (en) * | 1991-02-28 | 1993-02-09 | President And Fellows Of Harvard College | Ozone monitors |
| PL317192A1 (en) * | 1994-05-13 | 1997-03-17 | Monsanto Co | Methods of using pernitrite decomposition catalyst and their pharmaceutic compositions |
| US5729697A (en) * | 1995-04-24 | 1998-03-17 | International Business Machines Corporation | Intelligent shopping cart |
| US6861262B2 (en) * | 2000-03-03 | 2005-03-01 | Quest Diagnostics Investments Incorporated | Composition and method for detecting an adulterant in an aqueous sample |
| US7087766B2 (en) * | 2000-02-29 | 2006-08-08 | Daiichi Pure Chemicals Co., Ltd. | Reagents for the quantitation of active oxygen |
| US7599855B2 (en) * | 2001-02-13 | 2009-10-06 | Lester Sussman | System and method for a complete and convenient shopping experience |
| JP4206381B2 (ja) | 2002-10-16 | 2009-01-07 | 哲雄 長野 | パーオキシナイトライト測定用試薬 |
| CN100427928C (zh) * | 2005-01-17 | 2008-10-22 | 浙江大学 | 硝酸盐、亚硝酸盐快速测定试纸及其应用 |
| US7389934B2 (en) * | 2005-05-27 | 2008-06-24 | International Business Machines Corporation | On-demand point-of-sale scanner access |
-
2005
- 2005-10-07 US US11/245,529 patent/US7705040B2/en active Active
-
2006
- 2006-08-25 AU AU2006301818A patent/AU2006301818A1/en not_active Abandoned
- 2006-08-25 CA CA002624598A patent/CA2624598A1/en not_active Abandoned
- 2006-08-25 CN CN200680045462.9A patent/CN101321767B/zh active Active
- 2006-08-25 WO PCT/CN2006/002177 patent/WO2007041923A1/en not_active Ceased
- 2006-08-25 JP JP2008533849A patent/JP2009510462A/ja not_active Abandoned
- 2006-08-25 EP EP06775495A patent/EP1943254A4/en not_active Withdrawn
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