JP2009508842A - ヌクレオチド修飾による短鎖干渉リボ核酸(siRNA)の免疫賦活性の調節 - Google Patents
ヌクレオチド修飾による短鎖干渉リボ核酸(siRNA)の免疫賦活性の調節 Download PDFInfo
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Applications Claiming Priority (2)
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| US71759705P | 2005-09-16 | 2005-09-16 | |
| PCT/IB2006/003356 WO2007031877A2 (en) | 2005-09-16 | 2006-09-15 | Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification |
Publications (2)
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| JP2009508842A true JP2009508842A (ja) | 2009-03-05 |
| JP2009508842A5 JP2009508842A5 (https=) | 2010-01-07 |
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| EP (1) | EP1924692A2 (https=) |
| JP (1) | JP2009508842A (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013516190A (ja) * | 2010-01-07 | 2013-05-13 | クォーク ファーマシューティカルズ インコーポレーティッド | 非ヌクレオチドオーバーハングを含むオリゴヌクレオチド化合物 |
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| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| PT1077722E (pt) | 1998-05-22 | 2006-12-29 | Coley Pharm Group Inc | Produtos e composições para utilização na indução da imunidade mucosal |
| US7585847B2 (en) | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| AU2001270134B2 (en) | 2000-06-22 | 2006-06-15 | University Of Iowa Research Foundation | Methods for enhancing antibody-induced cell lysis and treating cancer |
| US8153141B2 (en) | 2002-04-04 | 2012-04-10 | Coley Pharmaceutical Gmbh | Immunostimulatory G, U-containing oligoribonucleotides |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
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| PT2241325E (pt) | 2002-10-29 | 2012-04-12 | Coley Pharm Gmbh | Utilização de oligonucleótidos cpg no tratamento de infecção com vírus da hepatite c |
| EP1578954A4 (en) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | 5'-CPG NUCLEIC ACIDS AND USE METHOD |
| BRPI0411514A (pt) * | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | antagonistas de receptor toll-like de molécula pequena |
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| AU2007280690C1 (en) | 2006-07-31 | 2012-08-23 | Curevac Gmbh | Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant |
| DE102006035618A1 (de) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
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| CA2635187A1 (en) | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
| ES2534947T3 (es) | 2009-03-25 | 2015-04-30 | The Board Of Regents Of The University Of Texas System | Composiciones para la estimulación de resistencia inmunitaria innata de mamíferos a patógenos |
| WO2010111891A1 (zh) | 2009-04-03 | 2010-10-07 | 北京大学 | 修饰的寡聚核酸分子及其制备方法和应用 |
| EP2694660B1 (en) | 2011-04-03 | 2018-08-08 | The General Hospital Corporation | Efficient protein expression in vivo using modified rna (mod-rna) |
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| US10286065B2 (en) | 2014-09-19 | 2019-05-14 | Board Of Regents, The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| WO2019217459A1 (en) | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| CA3160329A1 (en) * | 2019-11-06 | 2021-05-14 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| WO2021126281A1 (en) | 2019-12-20 | 2021-06-24 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof |
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| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7935675B1 (en) * | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030050263A1 (en) * | 1994-07-15 | 2003-03-13 | The University Of Iowa Research Foundation | Methods and products for treating HIV infection |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
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- 2006-09-15 SG SG201006744-5A patent/SG165394A1/en unknown
- 2006-09-15 BR BRPI0616069-7A patent/BRPI0616069A2/pt not_active IP Right Cessation
- 2006-09-15 US US11/992,073 patent/US20090306177A1/en not_active Abandoned
- 2006-09-15 AU AU2006290435A patent/AU2006290435A1/en not_active Abandoned
- 2006-09-15 KR KR1020087008950A patent/KR20080047463A/ko not_active Withdrawn
- 2006-09-15 CA CA002622761A patent/CA2622761A1/en not_active Abandoned
- 2006-09-15 EA EA200800838A patent/EA013375B1/ru not_active IP Right Cessation
- 2006-09-15 JP JP2008530660A patent/JP2009508842A/ja active Pending
- 2006-09-15 EP EP06820976A patent/EP1924692A2/en not_active Withdrawn
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2008
- 2008-03-13 IL IL190154A patent/IL190154A0/en unknown
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| WO2004065600A2 (en) * | 2003-01-17 | 2004-08-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Rna interference by palindromic or modified rna molecules |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013516190A (ja) * | 2010-01-07 | 2013-05-13 | クォーク ファーマシューティカルズ インコーポレーティッド | 非ヌクレオチドオーバーハングを含むオリゴヌクレオチド化合物 |
Also Published As
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|---|---|
| AU2006290435A1 (en) | 2007-03-22 |
| IL190154A0 (en) | 2008-08-07 |
| KR20080047463A (ko) | 2008-05-28 |
| EP1924692A2 (en) | 2008-05-28 |
| BRPI0616069A2 (pt) | 2011-06-07 |
| CN101321868A (zh) | 2008-12-10 |
| WO2007031877A2 (en) | 2007-03-22 |
| US20090306177A1 (en) | 2009-12-10 |
| EA200800838A1 (ru) | 2008-08-29 |
| WO2007031877A3 (en) | 2007-08-30 |
| CA2622761A1 (en) | 2007-03-22 |
| SG165394A1 (en) | 2010-10-28 |
| EA013375B1 (ru) | 2010-04-30 |
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