IL190154A0 - Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification - Google Patents
Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modificationInfo
- Publication number
- IL190154A0 IL190154A0 IL190154A IL19015408A IL190154A0 IL 190154 A0 IL190154 A0 IL 190154A0 IL 190154 A IL190154 A IL 190154A IL 19015408 A IL19015408 A IL 19015408A IL 190154 A0 IL190154 A0 IL 190154A0
- Authority
- IL
- Israel
- Prior art keywords
- sirna
- modulation
- ribonucleic acid
- short interfering
- nucleotide modification
- Prior art date
Links
- 108020004459 Small interfering RNA Proteins 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 title 1
- 230000002452 interceptive effect Effects 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 229920002477 rna polymer Polymers 0.000 title 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71759705P | 2005-09-16 | 2005-09-16 | |
| PCT/IB2006/003356 WO2007031877A2 (en) | 2005-09-16 | 2006-09-15 | Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL190154A0 true IL190154A0 (en) | 2008-08-07 |
Family
ID=37865319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL190154A IL190154A0 (en) | 2005-09-16 | 2008-03-13 | Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090306177A1 (https=) |
| EP (1) | EP1924692A2 (https=) |
| JP (1) | JP2009508842A (https=) |
| KR (1) | KR20080047463A (https=) |
| CN (1) | CN101321868A (https=) |
| AU (1) | AU2006290435A1 (https=) |
| BR (1) | BRPI0616069A2 (https=) |
| CA (1) | CA2622761A1 (https=) |
| EA (1) | EA013375B1 (https=) |
| IL (1) | IL190154A0 (https=) |
| SG (1) | SG165394A1 (https=) |
| WO (1) | WO2007031877A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| PT1077722E (pt) | 1998-05-22 | 2006-12-29 | Coley Pharm Group Inc | Produtos e composições para utilização na indução da imunidade mucosal |
| US7585847B2 (en) | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
| AU2001270134B2 (en) | 2000-06-22 | 2006-06-15 | University Of Iowa Research Foundation | Methods for enhancing antibody-induced cell lysis and treating cancer |
| US8153141B2 (en) | 2002-04-04 | 2012-04-10 | Coley Pharmaceutical Gmbh | Immunostimulatory G, U-containing oligoribonucleotides |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7569553B2 (en) | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7576066B2 (en) | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| PT2241325E (pt) | 2002-10-29 | 2012-04-12 | Coley Pharm Gmbh | Utilização de oligonucleótidos cpg no tratamento de infecção com vírus da hepatite c |
| EP1578954A4 (en) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | 5'-CPG NUCLEIC ACIDS AND USE METHOD |
| BRPI0411514A (pt) * | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | antagonistas de receptor toll-like de molécula pequena |
| GEP20094767B (en) | 2003-10-30 | 2009-09-10 | Coley Pharm Group Inc | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
| AU2007280690C1 (en) | 2006-07-31 | 2012-08-23 | Curevac Gmbh | Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant |
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| AU2006290435A1 (en) | 2007-03-22 |
| KR20080047463A (ko) | 2008-05-28 |
| EP1924692A2 (en) | 2008-05-28 |
| BRPI0616069A2 (pt) | 2011-06-07 |
| JP2009508842A (ja) | 2009-03-05 |
| CN101321868A (zh) | 2008-12-10 |
| WO2007031877A2 (en) | 2007-03-22 |
| US20090306177A1 (en) | 2009-12-10 |
| EA200800838A1 (ru) | 2008-08-29 |
| WO2007031877A3 (en) | 2007-08-30 |
| CA2622761A1 (en) | 2007-03-22 |
| SG165394A1 (en) | 2010-10-28 |
| EA013375B1 (ru) | 2010-04-30 |
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