WO2009143277A3 - Compositions comprising hscn9a sirna and methods of use thereof - Google Patents

Compositions comprising hscn9a sirna and methods of use thereof Download PDF

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Publication number
WO2009143277A3
WO2009143277A3 PCT/US2009/044719 US2009044719W WO2009143277A3 WO 2009143277 A3 WO2009143277 A3 WO 2009143277A3 US 2009044719 W US2009044719 W US 2009044719W WO 2009143277 A3 WO2009143277 A3 WO 2009143277A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
hscn9a
sirna
compositions
nucleic acid
Prior art date
Application number
PCT/US2009/044719
Other languages
French (fr)
Other versions
WO2009143277A2 (en
Inventor
Frank Y. Xie
Original Assignee
Intradigm Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intradigm Corporation filed Critical Intradigm Corporation
Publication of WO2009143277A2 publication Critical patent/WO2009143277A2/en
Publication of WO2009143277A3 publication Critical patent/WO2009143277A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides nucleic acid molecules that inhibit hSCN9A expression. Methods of using the nucleic acid molecules are also provided.
PCT/US2009/044719 2008-05-20 2009-05-20 Compositions comprising hscn9a sirna and methods of use thereof WO2009143277A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5477108P 2008-05-20 2008-05-20
US61/054,771 2008-05-20

Publications (2)

Publication Number Publication Date
WO2009143277A2 WO2009143277A2 (en) 2009-11-26
WO2009143277A3 true WO2009143277A3 (en) 2010-03-11

Family

ID=40910770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/044719 WO2009143277A2 (en) 2008-05-20 2009-05-20 Compositions comprising hscn9a sirna and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2009143277A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2016118528A (en) * 2010-06-23 2018-10-31 Курна, Инк. TREATMENT OF DISEASES ASSOCIATED WITH AN ALPHA SUBNITION OF A POTENTIAL DEPENDENT SODIUM CHANNEL (SCNA), BY INHIBITING A NATURAL ANTISOUND TRANSCRIPT OF THE SCNA GENE
JP7241019B2 (en) * 2017-01-24 2023-03-16 オリパス コーポレーション SCN9A antisense analgesic
WO2021247995A2 (en) 2020-06-04 2021-12-09 Voyager Therapeutics, Inc. Compositions and methods of treating neuropathic pain

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007109324A2 (en) * 2006-03-21 2007-09-27 Xenon Pharmaceuticals, Inc. Potent and selective nav 1.7 sodium channel blockers
WO2009033027A2 (en) * 2007-09-05 2009-03-12 Medtronic, Inc. Suppression of scn9a gene expression and/or function for the treatment of pain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007109324A2 (en) * 2006-03-21 2007-09-27 Xenon Pharmaceuticals, Inc. Potent and selective nav 1.7 sodium channel blockers
WO2009033027A2 (en) * 2007-09-05 2009-03-12 Medtronic, Inc. Suppression of scn9a gene expression and/or function for the treatment of pain

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KLUGBAUER NORBERT ET AL: "Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 14, no. 6, 1995, pages 1084 - 1090, XP002540498, ISSN: 0261-4189 *
KRAFTE DOUGLAS S ET AL: "Sodium channels and nociception: recent concepts and therapeutic opportunities.", CURRENT OPINION IN PHARMACOLOGY FEB 2008, vol. 8, no. 1, February 2008 (2008-02-01), pages 50 - 56, XP002540499, ISSN: 1471-4892 *
MEGURO KENTARO ET AL: "Function and role of voltage-gated sodium channel Na(V)1.7 expressed in aortic smooth muscle cells", AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY, vol. 296, no. 1, January 2009 (2009-01-01), pages H211 - H219, XP009121180, ISSN: 0363-6135 *
NAKAJIMA T ET AL: "Eicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells.", BRITISH JOURNAL OF PHARMACOLOGY FEB 2009, vol. 156, no. 3, February 2009 (2009-02-01), pages 420 - 431, XP002540501, ISSN: 1476-5381 *

Also Published As

Publication number Publication date
WO2009143277A2 (en) 2009-11-26

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