CN101321868A - 通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性 - Google Patents

通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性 Download PDF

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Publication number
CN101321868A
CN101321868A CNA2006800429468A CN200680042946A CN101321868A CN 101321868 A CN101321868 A CN 101321868A CN A2006800429468 A CNA2006800429468 A CN A2006800429468A CN 200680042946 A CN200680042946 A CN 200680042946A CN 101321868 A CN101321868 A CN 101321868A
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China
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sense strand
modified
nucleotide
sugar
sirna
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CNA2006800429468A
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Chinese (zh)
Inventor
E·尤尔曼
M·朱尔克
J·沃尔莫
C·舍特
M·韦伯
I·安迪奥
S·皮施
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Qiagen GmbH
Coley Pharmaceutical GmbH
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Qiagen GmbH
Coley Pharmaceutical GmbH
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CNA2006800429468A 2005-09-16 2006-09-15 通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性 Pending CN101321868A (zh)

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US71759705P 2005-09-16 2005-09-16
US60/717,597 2005-09-16

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CN101321868A true CN101321868A (zh) 2008-12-10

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CNA2006800429468A Pending CN101321868A (zh) 2005-09-16 2006-09-15 通过核苷酸修饰调节短干扰核糖核酸(siRNA)的免疫刺激特性

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US (1) US20090306177A1 (https=)
EP (1) EP1924692A2 (https=)
JP (1) JP2009508842A (https=)
KR (1) KR20080047463A (https=)
CN (1) CN101321868A (https=)
AU (1) AU2006290435A1 (https=)
BR (1) BRPI0616069A2 (https=)
CA (1) CA2622761A1 (https=)
EA (1) EA013375B1 (https=)
IL (1) IL190154A0 (https=)
SG (1) SG165394A1 (https=)
WO (1) WO2007031877A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108977446A (zh) * 2011-11-18 2018-12-11 阿尔尼拉姆医药品有限公司 修饰的RNAi试剂
CN114945669A (zh) * 2019-11-06 2022-08-26 阿尔尼拉姆医药品有限公司 肝外递送

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US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
PT1077722E (pt) 1998-05-22 2006-12-29 Coley Pharm Group Inc Produtos e composições para utilização na indução da imunidade mucosal
US7585847B2 (en) 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
AU2001270134B2 (en) 2000-06-22 2006-06-15 University Of Iowa Research Foundation Methods for enhancing antibody-induced cell lysis and treating cancer
US8153141B2 (en) 2002-04-04 2012-04-10 Coley Pharmaceutical Gmbh Immunostimulatory G, U-containing oligoribonucleotides
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