JP2009506124A5 - - Google Patents

Info

Publication number

JP2009506124A5

JP2009506124A5 JP2008529232A JP2008529232A JP2009506124A5 JP 2009506124 A5 JP2009506124 A5 JP 2009506124A5 JP 2008529232 A JP2008529232 A JP 2008529232A JP 2008529232 A JP2008529232 A JP 2008529232A JP 2009506124 A5 JP2009506124 A5 JP 2009506124A5

Authority

JP

Japan

Prior art keywords

antisense compound

use according

mir

nucleic acid

antisense

Prior art date

2006-08-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 30
• 230000000692 anti-sense effect Effects 0.000 claims 28
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 8
• 108091026501 miR-122a stem-loop Proteins 0.000 claims 6
• 239000002777 nucleoside Substances 0.000 claims 5
• 210000002966 serum Anatomy 0.000 claims 5
• 125000003835 nucleoside group Chemical group 0.000 claims 4
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 4
• 150000003833 nucleoside derivatives Chemical class 0.000 claims 3
• LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 2
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 208000030159 metabolic disease Diseases 0.000 claims 2
• 230000002503 metabolic effect Effects 0.000 claims 2
• YIMATHOGWXZHFX-WCTZXXKLSA-N (2r,3r,4r,5r)-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolane-2,4-diol Chemical compound COCCO[C@H]1[C@H](O)O[C@H](CO)[C@H]1O YIMATHOGWXZHFX-WCTZXXKLSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
• 238000008214 LDL Cholesterol Methods 0.000 claims 1
• 108010028554 LDL Cholesterol Proteins 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 108091007780 MiR-122 Proteins 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 125000002619 bicyclic group Chemical group 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 229940104302 cytosine Drugs 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 108091051828 miR-122 stem-loop Proteins 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1