JP2009504803A5 - - Google Patents
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- JP2009504803A5 JP2009504803A5 JP2008528017A JP2008528017A JP2009504803A5 JP 2009504803 A5 JP2009504803 A5 JP 2009504803A5 JP 2008528017 A JP2008528017 A JP 2008528017A JP 2008528017 A JP2008528017 A JP 2008528017A JP 2009504803 A5 JP2009504803 A5 JP 2009504803A5
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- Japan
- Prior art keywords
- alkyl
- compound according
- compound
- aryl
- substituted
- Prior art date
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71033705P | 2005-08-22 | 2005-08-22 | |
| PCT/US2006/032371 WO2007024707A2 (en) | 2005-08-22 | 2006-08-21 | Tlr agonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012254043A Division JP2013040209A (ja) | 2005-08-22 | 2012-11-20 | Tlrアゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504803A JP2009504803A (ja) | 2009-02-05 |
| JP2009504803A5 true JP2009504803A5 (enExample) | 2009-10-01 |
Family
ID=37772216
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008528017A Pending JP2009504803A (ja) | 2005-08-22 | 2006-08-21 | Tlrアゴニスト |
| JP2012254043A Pending JP2013040209A (ja) | 2005-08-22 | 2012-11-20 | Tlrアゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012254043A Pending JP2013040209A (ja) | 2005-08-22 | 2012-11-20 | Tlrアゴニスト |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090324551A1 (enExample) |
| EP (1) | EP1931352B1 (enExample) |
| JP (2) | JP2009504803A (enExample) |
| CN (1) | CN101304748A (enExample) |
| CA (1) | CA2620182A1 (enExample) |
| ES (1) | ES2577514T3 (enExample) |
| WO (1) | WO2007024707A2 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2497765A1 (en) * | 2002-09-27 | 2004-04-08 | Sumitomo Pharmaceuticals Co., Ltd. | 8-hydroxy substituted adenine compounds and uses thereof |
| BRPI0509258A8 (pt) | 2004-03-26 | 2019-01-22 | Astrazeneca Ab | composto de 8-oxoadenina 9-substituída |
| CA2620182A1 (en) | 2005-08-22 | 2007-03-01 | Dennis A. Carson | Tlr agonists |
| EP1939202A4 (en) * | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| US8846697B2 (en) | 2006-05-31 | 2014-09-30 | The Regents Of The University Of California | Purine analogs |
| JP2009542645A (ja) | 2006-07-05 | 2009-12-03 | アストラゼネカ・アクチエボラーグ | Tlr7のモジュレーターとして作用する8−オキソアデニン誘導体 |
| TW200831105A (en) * | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| EP2510946B1 (en) | 2007-02-07 | 2015-08-05 | The Regents of The University of California | Conjugates of synthetic tlr agonists and uses therefor |
| JP2010519186A (ja) * | 2007-02-19 | 2010-06-03 | スミスクライン ビーチャム コーポレーション | 免疫調節物質としてのプリン誘導体 |
| EP2132209B8 (en) * | 2007-03-19 | 2014-04-16 | AstraZeneca AB | 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators |
| JP5329444B2 (ja) * | 2007-03-19 | 2013-10-30 | アストラゼネカ・アクチエボラーグ | Toll様受容体(tlr7)モジュレーターとしての9−置換−8−オキソ−アデニン化合物 |
| EP2138497A4 (en) | 2007-03-20 | 2012-01-04 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| TW200902018A (en) * | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Novel adenine compound |
| BRPI0811125A2 (pt) * | 2007-05-08 | 2017-05-09 | Astrazeneca Ab | imidazoquinolinas com propriedades imunomoduladoras |
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| US20110054168A1 (en) * | 2008-01-17 | 2011-03-03 | Ayumu Kurimoto | Method for preparing adenine compound |
| US8865896B2 (en) * | 2008-01-17 | 2014-10-21 | Astrazeneca Aktiebolag | Method for preparing adenine compound |
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| BR112012009329A2 (pt) | 2009-10-22 | 2016-06-07 | Gilead Sciences Inc | derivados de purina ou deazapurina úteis para o tratamento de infecções virais (inter alia) |
| JP2013512859A (ja) * | 2009-12-03 | 2013-04-18 | 大日本住友製薬株式会社 | トール様受容体(tlr)を介して作用するイミダゾキノリン |
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| US9050319B2 (en) | 2010-04-30 | 2015-06-09 | Telormedix, Sa | Phospholipid drug analogs |
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| CN107029223A (zh) | 2010-05-26 | 2017-08-11 | 西莱克塔生物科技公司 | 合成纳米载体联合疫苗 |
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| CN103370317B (zh) | 2010-12-16 | 2015-10-07 | 阿斯利康(瑞典)有限公司 | 可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物 |
| WO2012080730A1 (en) | 2010-12-17 | 2012-06-21 | Astrazeneca Ab | Purine derivatives |
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| RU2014103159A (ru) * | 2011-07-22 | 2015-08-27 | Павел КАЛИНСКИЙ | Опухолесективная модуляция хемокинов |
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| US9173872B2 (en) | 2012-08-24 | 2015-11-03 | Glaxosmithkline Llc | Pyrazolopyrimidine compounds |
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| JP6216387B2 (ja) | 2012-11-20 | 2017-10-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 新規化合物 |
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| SI3166607T1 (sl) | 2014-07-11 | 2023-01-31 | Gilead Sciences, Inc. | Modulatorji toličnih receptorjev za zdravljenje HIV-a |
| ES2944541T3 (es) | 2014-08-06 | 2023-06-22 | Scripps Research Inst | Adyuvantes de molécula pequeña independientes de TLR |
| CN112898308B (zh) * | 2014-08-15 | 2026-08-07 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| CN110305133A (zh) | 2014-09-16 | 2019-10-08 | 吉利德科学公司 | Toll样受体调节剂的固体形式 |
| KR102112192B1 (ko) | 2015-11-05 | 2020-05-19 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Tlr7 효능제로서의 7-(티아졸-5-일)피롤로피리미딘 화합물 |
| CN107043379A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
| BR112019000071A2 (pt) | 2016-07-07 | 2019-07-02 | Bolt Biotherapeutics Inc | conjugados adjuvantes de anticorpo |
| CA3045944A1 (en) | 2016-12-07 | 2018-06-14 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018112108A1 (en) | 2016-12-13 | 2018-06-21 | Bolt Biotherapeutics, Inc. | Antibody adjuvant conjugates |
| WO2018112223A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a tlr modulator |
| PL3609540T3 (pl) | 2017-04-14 | 2023-03-27 | Bolt Biotherapeutics, Inc. | Sposób syntezy immunokoniugatu |
| JP2021035910A (ja) * | 2017-11-01 | 2021-03-04 | 大日本住友製薬株式会社 | 置換プリン化合物 |
| WO2019196918A1 (zh) * | 2018-04-13 | 2019-10-17 | 罗欣药业(上海)有限公司 | 五元杂环并嘧啶类化合物、药物组合物及用途 |
| US20210154316A1 (en) | 2018-05-17 | 2021-05-27 | Bolt Biotherapeutics, Inc. | Immunoconjugates |
| CN109608462B (zh) * | 2018-12-15 | 2021-11-23 | 华南理工大学 | 一种7-烃基-9-烷氧/硫基嘌呤-8-酮类化合物及其合成方法与在药物中的应用 |
| EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| CN113924114A (zh) | 2019-05-22 | 2022-01-11 | 吉利德科学公司 | Tlr7调节化合物和hiv疫苗的组合 |
| WO2021046347A1 (en) | 2019-09-04 | 2021-03-11 | Bolt Biotherapeutics, Inc. | Immunoconjugate synthesis method |
| WO2021174024A1 (en) | 2020-02-28 | 2021-09-02 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| EP4175640A1 (en) | 2020-07-02 | 2023-05-10 | VIIV Healthcare Company | Method of achieving hiv viral remission using long-acting antiretroviral agents |
| EP4219504A4 (en) * | 2020-09-27 | 2024-10-16 | Shanghai Visonpharma Co., Ltd. | MACROCYCLIC TLR7 AGONIST, MANUFACTURING METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
| EP4232094A1 (en) | 2020-10-21 | 2023-08-30 | Univerza V Ljubljani | Conjugated tlr7 and nod2 agonists |
| CN115819215B (zh) * | 2022-11-08 | 2024-09-13 | 广东省科学院化工研究所 | 一种路易斯酸催化合成羧酸衍生物的方法 |
| WO2025040743A1 (en) | 2023-08-22 | 2025-02-27 | Univerza V Ljubljani | Conjugated tlr7 and rig-i agonists |
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| WO2005092892A1 (ja) | 2004-03-26 | 2005-10-06 | Dainippon Sumitomo Pharma Co., Ltd. | 8−オキソアデニン化合物 |
| WO2006054129A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
| US8105632B2 (en) | 2004-12-07 | 2012-01-31 | University Of Miami | Cell-derived microparticles as hemostatic agents for control of hemorrhage and treatment of bleeding disorders |
| BRPI0609399A2 (pt) | 2005-03-21 | 2010-03-30 | Ferrer Int | método para produzir compostos da 1h-imidazo[4,5-c]quinolin-4-amina 1-substituìda e intermediários dos mesmos |
| US20070292418A1 (en) * | 2005-04-26 | 2007-12-20 | Eisai Co., Ltd. | Compositions and methods for immunotherapy |
| CA2620182A1 (en) | 2005-08-22 | 2007-03-01 | Dennis A. Carson | Tlr agonists |
| WO2007034917A1 (ja) | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | 新規なアデニン化合物 |
| EP1939202A4 (en) | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| WO2007038720A2 (en) | 2005-09-27 | 2007-04-05 | Coley Pharmaceutical Gmbh | Modulation of tlr-mediated immune responses using adaptor oligonucleotides |
| US20070100146A1 (en) * | 2005-11-03 | 2007-05-03 | Trevor Dzwiniel | Process for the preparation of imidazo[4,5-c]-quinolin-4-amines |
| US8846697B2 (en) | 2006-05-31 | 2014-09-30 | The Regents Of The University Of California | Purine analogs |
| US8338593B2 (en) * | 2006-07-07 | 2012-12-25 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
| US7902187B2 (en) * | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| TW200831104A (en) * | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| EP2510946B1 (en) | 2007-02-07 | 2015-08-05 | The Regents of The University of California | Conjugates of synthetic tlr agonists and uses therefor |
| EP2170888B1 (en) | 2007-06-29 | 2015-04-22 | Gilead Sciences, Inc. | Purine derivatives and their use as modulators of toll-like receptor 7 |
| JP2011500716A (ja) | 2007-10-16 | 2011-01-06 | ギリアード・パロ・アルト・インコーポレイテッド | A3アデノシン受容体アンタゴニスト |
| WO2009099650A2 (en) | 2008-02-07 | 2009-08-13 | Carson Dennis A | Treatment of bladder diseases with a tlr7 activator |
| WO2010088924A1 (en) * | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| KR20110117705A (ko) * | 2009-02-11 | 2011-10-27 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 톨-유사 수용체 조정제 및 질병의 치료 |
| BR112012009329A2 (pt) | 2009-10-22 | 2016-06-07 | Gilead Sciences Inc | derivados de purina ou deazapurina úteis para o tratamento de infecções virais (inter alia) |
| EP2563366A4 (en) | 2010-04-30 | 2013-11-20 | Univ California | USE OF PHOSPHOLIPID CONJUGATES FROM SYNTHETIC TLR7 AGONISTS |
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-
2006
- 2006-08-21 CA CA002620182A patent/CA2620182A1/en not_active Abandoned
- 2006-08-21 CN CNA200680038761XA patent/CN101304748A/zh active Pending
- 2006-08-21 EP EP06813535.9A patent/EP1931352B1/en not_active Expired - Lifetime
- 2006-08-21 US US12/064,529 patent/US20090324551A1/en not_active Abandoned
- 2006-08-21 ES ES06813535.9T patent/ES2577514T3/es not_active Expired - Lifetime
- 2006-08-21 JP JP2008528017A patent/JP2009504803A/ja active Pending
- 2006-08-21 WO PCT/US2006/032371 patent/WO2007024707A2/en not_active Ceased
-
2012
- 2012-11-20 JP JP2012254043A patent/JP2013040209A/ja active Pending
- 2012-11-20 US US13/682,208 patent/US9359360B2/en not_active Expired - Lifetime
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