JP2009502829A5 - - Google Patents
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- Publication number
- JP2009502829A5 JP2009502829A5 JP2008523188A JP2008523188A JP2009502829A5 JP 2009502829 A5 JP2009502829 A5 JP 2009502829A5 JP 2008523188 A JP2008523188 A JP 2008523188A JP 2008523188 A JP2008523188 A JP 2008523188A JP 2009502829 A5 JP2009502829 A5 JP 2009502829A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- halogen
- aryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05016154 | 2005-07-26 | ||
| EP05016154.6 | 2005-07-26 | ||
| PCT/EP2006/007139 WO2007012421A1 (en) | 2005-07-26 | 2006-07-20 | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502829A JP2009502829A (ja) | 2009-01-29 |
| JP2009502829A5 true JP2009502829A5 (cg-RX-API-DMAC7.html) | 2009-09-03 |
| JP5060478B2 JP5060478B2 (ja) | 2012-10-31 |
Family
ID=34979095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008523188A Active JP5060478B2 (ja) | 2005-07-26 | 2006-07-20 | Ｒｈｏ−キナーゼ阻害剤としてのピペリジニル置換されたイソキノロン誘導体 |
Country Status (31)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2443688C2 (ru) | 2005-06-28 | 2012-02-27 | Санофи-Авентис | ПРОИЗВОДНЫЕ ИЗОХИНОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| KR101336678B1 (ko) | 2005-07-26 | 2013-12-04 | 사노피 | Ｒｈｏ-키나제 억제제로서의 사이클로헥실아민 이소퀴놀론유도체 |
| TW200738682A (en) * | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| WO2008033757A2 (en) * | 2006-09-11 | 2008-03-20 | N.V. Organon | 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives |
| JP5405314B2 (ja) | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノロン誘導体 |
| KR20090094338A (ko) | 2006-12-27 | 2009-09-04 | 사노피-아벤티스 | 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
| NZ577984A (en) | 2006-12-27 | 2011-03-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| ATE502027T1 (de) | 2006-12-27 | 2011-04-15 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
| JP5421783B2 (ja) | 2006-12-27 | 2014-02-19 | サノフイ | Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 |
| MY151953A (en) | 2006-12-27 | 2014-07-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline derivatives |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| MX2009007831A (es) * | 2007-01-22 | 2010-01-15 | Gtx Inc | Agentes de union de receptor nuclear. |
| CA2710447A1 (en) * | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Process for the preparation of 6-substituted-1-(2h)-isoquinolinones |
| AU2009262517B2 (en) | 2008-06-24 | 2014-01-09 | Sanofi | Substituted isoquinolines and isoquinolinones as Rho kinase inhibitors |
| ES2436531T3 (es) | 2008-06-24 | 2014-01-02 | Sanofi | Isoquinolinas e isoquinolinonas sustituidas en posición 6 |
| PT2303845E (pt) | 2008-06-24 | 2013-11-25 | Sanofi Sa | Derivados de isoquinolina e isoquinolina substituída com bi- e policíclicos como inibidores de rho-cinase |
| US9865233B2 (en) | 2008-12-30 | 2018-01-09 | Intel Corporation | Hybrid graphics display power management |
| JP2013507417A (ja) * | 2009-10-13 | 2013-03-04 | エム・エス・ディー・オス・ベー・フェー | アセチルコリン受容体に関連する疾患の処置のための縮合アジン誘導体 |
| CN103957711A (zh) * | 2011-07-04 | 2014-07-30 | 拜耳知识产权有限责任公司 | 取代的异喹啉酮、异喹啉二酮、异喹啉三酮和二氢异喹啉酮或其各自的盐作为活性剂对抗植物非生物胁迫的用途 |
| KR101959711B1 (ko) | 2011-07-08 | 2019-03-19 | 사노피 | 치환된 페닐 화합물 |
| RU2014104357A (ru) * | 2011-07-08 | 2015-08-20 | Санофи | Полиморфы гидрохлорида 6-(пиперидин-4-илокси)-2н-изохинолин-1-она |
| HRP20160356T1 (hr) * | 2011-07-08 | 2016-05-06 | Sanofi | Kristalni solvati 6-(piperidin-4-iloksi)-2h-izokinolin-1-on hidroklorida |
| EP2740458B1 (en) | 2012-12-06 | 2016-08-03 | IP Gesellschaft für Management mbH | Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide |
| US9034900B2 (en) | 2013-10-18 | 2015-05-19 | Quanticel Pharmaceuticals, Inc. | Bromodomain inhibitors |
| LT3071203T (lt) | 2013-11-18 | 2021-05-25 | Forma Therapeutics, Inc. | Tetrahidrochinolino kompozicijos kaip bet bromodomeno inhibitoriai |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN107207498B (zh) | 2014-12-24 | 2020-03-24 | 吉利德科学公司 | 用于治疗hiv的稠合嘧啶化合物 |
| TWI770552B (zh) | 2014-12-24 | 2022-07-11 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| ES2705709T3 (es) | 2014-12-24 | 2019-03-26 | Gilead Sciences Inc | Compuestos de isoquinolina para el tratamiento del VIH |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| WO2017003723A1 (en) | 2015-07-01 | 2017-01-05 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| US11096909B2 (en) * | 2016-04-06 | 2021-08-24 | University Of Oulu | Compounds for use in the treatment of cancer |
| EP3445750A4 (en) | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| CN106632258B (zh) * | 2016-12-15 | 2019-04-02 | 三峡大学 | 四氢异喹啉-2-基芳氧基苯氧基烷基酮化合物及其应用 |
| WO2019023278A1 (en) | 2017-07-25 | 2019-01-31 | Crinetics Pharmaceuticals, Inc. | MODULATORS OF SOMATOSTATIN AND USES THEREOF |
| US11738030B2 (en) | 2021-10-30 | 2023-08-29 | Aneuryst, Inc. | Treatments for disturbed cerebral homeostasis |
| CA3260779A1 (en) * | 2022-08-01 | 2024-02-08 | Valo Health, Inc. | PROCESS FOR PREPARATION OF 1-(2H)-ISOQUINOLINONES SUBSTITUTED AT POSITION 6 AND INTERMEDIATE COMPOUND |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| WO1992002476A1 (en) | 1990-07-31 | 1992-02-20 | E.I. Du Pont De Nemours And Company | Catalytic equilibration of selected halocarbons |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| RU2167865C2 (ru) * | 1995-09-07 | 2001-05-27 | Ф. Хоффманн-Ля Рош Аг | Производные пиперидина, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| IL128456A0 (en) | 1996-08-12 | 2000-01-31 | Yoshitomi Pharmaceutical | Compositions containing a Rho kinase inhibitor |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| JP2001514259A (ja) | 1997-08-29 | 2001-09-11 | ゼネカ・リミテッド | アミノメチルオキソオキサゾリジニルベンゼン誘導体 |
| TW575567B (en) | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
| GB9912701D0 (en) | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
| US6541456B1 (en) | 1999-12-01 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| RU2259365C2 (ru) | 2000-01-20 | 2005-08-27 | Эйсай Ко., Лтд. | Пиперидиновое соединение, способ его получения, фармацевтическая композиция и способ ингибирования натриевых каналов и калиевых каналов |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| US20040171533A1 (en) | 2000-02-29 | 2004-09-02 | Barbara Zehentner | Methods and compositions for regulating adiopocytes |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| WO2002034712A1 (en) | 2000-10-27 | 2002-05-02 | Takeda Chemical Industries, Ltd. | Process for preparing substituted aromatic compounds and intermediates therefor |
| EP1351936A1 (en) | 2001-01-15 | 2003-10-15 | Glaxo Group Limited | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
| SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
| JP2004534017A (ja) | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｂａｃｅのインヒビター |
| JPWO2002100833A1 (ja) | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| CA2493230A1 (en) * | 2002-07-22 | 2004-01-29 | Asahi Kasei Pharma Corporation | 5-substituted isoquinoline derivative |
| EP1550660A1 (en) | 2002-09-12 | 2005-07-06 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same |
| US20050014783A1 (en) | 2003-05-29 | 2005-01-20 | Schering Aktiengesellschaft | Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy |
| EP1638939A2 (en) | 2003-06-24 | 2006-03-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| AU2004275720B2 (en) | 2003-09-23 | 2008-04-24 | Merck Sharp & Dohme Corp. | Isoquinoline potassium channel inhibitors |
| EP1667982B1 (en) | 2003-09-23 | 2013-07-31 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| US20050067037A1 (en) | 2003-09-30 | 2005-03-31 | Conocophillips Company | Collapse resistant composite riser |
| WO2005035516A1 (ja) | 2003-10-10 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 新規縮合複素環化合物およびその用途 |
| JP2007008816A (ja) * | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
| EP1689719A1 (en) | 2003-11-25 | 2006-08-16 | Eli Lilly And Company | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b) |
| WO2005074535A2 (en) | 2004-01-30 | 2005-08-18 | Eisai Co., Ltd. | Cholinesterase inhibitors for spinal cord disorders |
| EP1729761A4 (en) | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | TREATMENT OF CADASIL WITH CHOLINESTERASE INHIBITORS |
| SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| US7517991B2 (en) | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| KR101336678B1 (ko) | 2005-07-26 | 2013-12-04 | 사노피 | Ｒｈｏ-키나제 억제제로서의 사이클로헥실아민 이소퀴놀론유도체 |
| TW200745101A (en) | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
| US7618985B2 (en) | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
| TW200738682A (en) * | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| US7893088B2 (en) | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| NZ577984A (en) | 2006-12-27 | 2011-03-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| ATE502027T1 (de) | 2006-12-27 | 2011-04-15 | Sanofi Aventis | Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren |
-
2006
- 2006-07-20 WO PCT/EP2006/007139 patent/WO2007012421A1/en not_active Ceased
- 2006-07-20 PT PT67763060T patent/PT1910333E/pt unknown
- 2006-07-20 JP JP2008523188A patent/JP5060478B2/ja active Active
- 2006-07-20 MX MX2008001053A patent/MX2008001053A/es active IP Right Grant
- 2006-07-20 NI NI200800025A patent/NI200800025A/es unknown
- 2006-07-20 CA CA2615577A patent/CA2615577C/en active Active
- 2006-07-20 NZ NZ565668A patent/NZ565668A/en not_active IP Right Cessation
- 2006-07-20 BR BRPI0613861A patent/BRPI0613861B8/pt active IP Right Grant
- 2006-07-20 EP EP06776306.0A patent/EP1910333B1/en active Active
- 2006-07-20 CN CN2006800271613A patent/CN101228149B/zh active Active
- 2006-07-20 ES ES06776306T patent/ES2423006T3/es active Active
- 2006-07-20 EP EP11176273.8A patent/EP2385047B1/en active Active
- 2006-07-20 KR KR1020087002168A patent/KR101373535B1/ko active Active
- 2006-07-20 DK DK06776306.0T patent/DK1910333T3/da active
- 2006-07-20 UA UAA200802430A patent/UA93882C2/ru unknown
- 2006-07-20 AU AU2006274245A patent/AU2006274245B2/en active Active
- 2006-07-20 RU RU2008106950/04A patent/RU2414467C2/ru active
- 2006-07-24 MY MYPI20063515A patent/MY148479A/en unknown
- 2006-07-24 GT GT200600328A patent/GT200600328A/es unknown
- 2006-07-24 TW TW095126882A patent/TWI383979B/zh active
- 2006-07-25 PE PE2006000896A patent/PE20070217A1/es not_active Application Discontinuation
- 2006-07-25 AR ARP060103199A patent/AR054868A1/es active IP Right Grant
- 2006-07-25 DO DO2006000178A patent/DOP2006000178A/es unknown
- 2006-07-26 UY UY29697A patent/UY29697A1/es not_active Application Discontinuation
-
2007
- 2007-12-18 CR CR9603A patent/CR9603A/es not_active Application Discontinuation
- 2007-12-18 ZA ZA200701095A patent/ZA200710951B/xx unknown
-
2008
- 2008-01-10 IL IL188702A patent/IL188702A/en active IP Right Grant
- 2008-01-18 MA MA30583A patent/MA29636B1/fr unknown
- 2008-01-25 US US12/019,866 patent/US8188117B2/en active Active
- 2008-01-25 TN TNP2008000039A patent/TNSN08039A1/en unknown
- 2008-01-25 EC EC2008008135A patent/ECSP088135A/es unknown
- 2008-02-22 NO NO20080963A patent/NO341888B1/no unknown
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