JP2009167134A - セラミド分散剤及びセラミド組成物 - Google Patents
セラミド分散剤及びセラミド組成物 Download PDFInfo
- Publication number
- JP2009167134A JP2009167134A JP2008008075A JP2008008075A JP2009167134A JP 2009167134 A JP2009167134 A JP 2009167134A JP 2008008075 A JP2008008075 A JP 2008008075A JP 2008008075 A JP2008008075 A JP 2008008075A JP 2009167134 A JP2009167134 A JP 2009167134A
- Authority
- JP
- Japan
- Prior art keywords
- ceramide
- acid
- cellooligosaccharide
- composition
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims abstract description 87
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 87
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Abstract
【解決手段】セロオリゴ糖を含有するセラミド分散剤。
【選択図】なし
Description
セラミドが不足すると、皮膚の健康に障害をきたすため、化粧品、医薬部外品、医薬品において皮膚外用剤又は毛髪用剤に配合し、補給することがなされてきた。
セラミドは、水系媒体、油性媒体のいずれにも、親和性が乏しく、均一分散しにくく、製剤としにくい問題があった。また、一旦、分散しても、保存中に析出し、離水する等の問題を生じることがあった。
従って、セラミドを外用剤にもちいるにあたり、刺激性がなく、安全で、安定性に優れる物質による、均一分散が望まれていた。
すなわち、本発明は、下記の通りである。
(1) セロオリゴ糖を含有するセラミド分散剤。
(2) 前記セロオリゴ糖におけるセロビオース含量が70質量%以上であり、セロトリオース、セロテトラオース、セロペンタオースおよびセロヘキサオースから選ばれる1種以上の糖の含量が30質量%以下である、(1)に記載のセラミド分散剤。
(3) (1)または(2)の何れかに記載のセラミド分散剤を用いて水系媒体に分散したセラミドを含むセラミド組成物であって、セラミドに対し0.005質量%以上のセロオリゴ糖を含有することを特徴とする、セラミド組成物。
(4) さらに脂肪酸及び/又はステロール類を含有する、(3)に記載のセラミド組成物。
(5) 皮膚バリヤ機能改善剤として用いる、(3)又は(4)に記載のセラミド組成物。
本発明のセラミド分散剤は、セロオリゴ糖を含むことが必要である。
セロオリゴ糖は、セロビオース、セロトリオース、セロテトラオース、セロペンタオース、セロヘキサオース等の2分子以上のグルコースがβ―1,4結合した糖類の総称であり、本発明では、これらのうち一種以上を含むものである。
本発明のセロオリゴ糖の起源には、特に制限はなく、セルロース系物質の加水分解で製造されたもの、グルコース等の単糖類またはその誘導体を縮合または糖転移させ製造されたものでもよいが、酵素分解法で得られたものが、安全性の点で好ましい。
上記方法において、懸濁方法、攪拌方法、セルラーゼ・基質の添加方法・添加順序、それらの濃度等の反応条件は、セロオリゴ糖がより高収率で得られるよう適宜調整されるものである。その際の、反応液のpH及び温度は、酵素が失活しない範囲内であればよく、一般的には、常圧で反応を行う場合、温度は5〜95℃、pHは1〜11の範囲でよい。また、この圧力、温度、pHについても、上記同様、セロオリゴ糖がより高収率で得られるよう適宜調整されるものである。
セロオリゴ糖の精製方法の中でも、晶析処理は、セロオリゴ糖の組成を制御しやすいため好ましい。
本発明のセラミド組成物は、溶解、混合、分散、造粒、溶融・固化、圧縮、乾燥等の公知の方法で加工できる。
各成分の添加方法は、通常行われている方法であれば特に制限はないが、1)セロオリゴ糖と構成成分を同時に添加し、混合/分散しても、2)セロオリゴ糖と特定の構成成分を予め混合/分散した後に、別の構成成分を添加し、混合/分散しても、3)2種以上の構成成分を予め混合/分散した後、セロオリゴ糖を添加し、混合/分散しても、これらの添加方法を組み合わせた方法でもよい。
例えば、化粧品素材またはそこで使用される添加剤としては、本発明のセロオリゴ糖に加え、必要に応じて、保湿剤、アミノ酸、ビタミン類、炭化水素、高級脂肪酸、エステル類、シリコン、界面活性剤、pH調整剤、水を添加してもよい。これらの化粧品素材または添加剤は、それを単独で使用しても、2種以上を併用することも自由である。
高級脂肪酸としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベへリン酸、オレイン酸、ヒドロキシステアリン酸、ウンデシレン酸、イソステアリン酸、リノール酸、リノレン酸、エイコサペンタエン酸、ドコサヘキサエン酸等の「化粧品原料基準」(薬事日報社発行)に高級脂肪酸として分類されるものが挙げられる。
次に、医薬品/医薬部外品において使用する添加剤について記載する。
香料としては、オレンジ、バニラ、ストロベリー、ヨーグルト、メントール、ウイキョウ油、ケイヒ油、トウヒ油、ハッカ油等の油類、緑茶末等の「医薬品添加剤事典」(薬事日報社(株)発行)、「日本薬局方」(廣川書店発行)に着香剤、香料として分類されるものを挙げることができる。上記から選ばれる1種を単独で使用しても、2種以上を併用することも自由である。
甘味剤としては、アスパルテーム、サッカリン、グリチルリチン酸二カリウム、ステビア、マルトース、マルチトール、水飴、アマチャ末等の「医薬品添加剤事典」(薬事日報社(株)発行)、「日本薬局方」(廣川書店発行)に甘味剤として分類されるものを挙げることができる。上記から選ばれる1種を単独で使用しても、2種以上を併用することも自由である。
油脂としては、例えば、ステアリン酸モノグリセリド、ステアリ ン酸トリグリセリド、ステア リン酸ショ糖エステル、流動パラフィン等のパラフィン類、カルナウバロウ,硬化ヒマシ油等の硬化油類、ヒマシ油、ステアリン酸、ステアリルアルコール、ポリエチレングリコール等の「医薬品添加剤事典」(薬事日報社(株)発行)、「日本薬局方」(廣川書店発行)に記載される油脂が挙げられ、それを単独で使用しても、2種以上を併用することも自由である。
界面活性剤としては、例えば、リン脂質、グリセリン脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンセチルエーテル、ポリオキシエチレンステアリルエーテル、ポリオキシエチレンノニルフェニルエーテル、ポリオキシエチレンポリオキシプロピレングリコール、ポリオキシエチレンソルビタンサンモノラウレート、ポリソルベート、モノオレイン酸ソルビタン、モノステアリン酸グリセリド、モノオキシエチレンソルビタンモノパルミテート、モノオキシエチレンソルビタンモノステアレート、モノオレイン酸ポリオキシエチレンソルビタン、モノパルミチン酸ソルビタン、ラウリル硫酸ナトリウム等の「医薬品添加剤事典」(薬事日報社(株)発行)、「日本薬局方」(廣川書店発行)に界面活性剤として分類されるものが挙げられ、それを単独で使用しても、2種以上を併用することも自由である。
化粧品としては、例えば、香油、ヘアオイル、つや出し油、スキ油、びん油、セットローション、ヘアスティック、ヘアクリーム、ポマード、ヘアスプレー、ヘアリキッド等の整髪料、ヘアトニック、ヘアトリートメント、ヘアローション等の養毛料、カラースプレー、カラーリンス等の毛髪着色料、頭皮料、髪洗粉、シャンプー等の洗髪料、ヘアリンス、オイルリンス、クリームリンス、ボディリンス、フェイシャルリンス等のリンス、クレンジングクリーム、洗顔クリーム、クレンジングミルク、クレンジングローション、洗粉等の洗顔料、パック、油性クリーム、中性クリーム、弱酸性クリーム等のクリーム、ミルクローション、スキンミルク等の乳液、乾性肌用化粧水、普通肌用化粧水、脂肌用化粧水、男性用化粧水、男性ローション、アフターシェーブローション等の化粧水、メイクアップベース、ファンデーション、おしろい、口紅、リップスティック、リップルージュ、リップグロス、リップクリーム等の口紅類、アイシャドー、アイライナー、アイクリーム、眉墨、まつげ化粧料、アイメイクアップリムーバー、アイメイクアップ、頬紅、アイブロウペンシル、アイブロウブラッシュ、マスカラ等の眉目頬化粧料、ネイルエナメル、ネイルクリーム、マニキュア、ペディキュア、エナメルリムーバー、除光液等の美爪料、香水、オーデコロン、パヒュームコロン、オードトワレ等のオーデコロン、バスソルト、バスオイル等の浴用化粧品、オリーブ油、椿油、ベビーオイル等を配合した化粧油、日焼け用化粧品、コールドクリーム、日焼けどめ化粧品、ひげそりクリーム、シェービングフォーム等のシェービングクリーム、プレシェーブ化粧品、タルカムパウダー、ボディパウダー、バスパウダー、パヒュームパウダー等の打粉等の「化粧品科学ガイドブック」(日本化粧品技術者会編、薬事日報社発行)に記載される化粧品が挙げられ、これらに分類されるものに使用してもよい。
<セロオリゴ糖の製造方法>
[製造例1]
普通寒天培地にトリコデルマ リーセイ(Tricoderma reesei)GL−1株(独立行政法人産業技術総合研究所 特許生物寄託センター、受領番号FERM BP−10323)を接種し、28℃で7日間培養後、その培地表面から胞子を1白金耳取り、ポリペプトン1g、酵母エキス0.5g、リン酸1カリウム2g、硫酸アンモニウム1.5g、硫酸マグネシウム0.3g、塩化カルシウム0.3g、トレースエレメント1mL(硼酸6mg、モリブデン酸アンモニウム4水和物26mg、塩化鉄(3)6水和物100mg、硫酸銅5水和物40mg、硫酸マンガン4水和物8mg、硫酸亜鉛7水和物200mgを全量100mLの精製水に溶解させたもの)、アデカノール1mL、結晶セルロース(旭化成ケミカルズ製 商品名PH−101)10gを全量1Lの精製水に懸濁および溶解させた培地に植菌し、28℃で5日間通気攪拌培養した。培養中は、リン酸水溶液、水酸化ナトリウム水溶液を用いて、培地のpHを2.8−4.7となるように調節した。培養後の液を遠心分離し、上清を目開き0.46μmの精密ろ過膜で除菌し、ろ液を分画分子量13000の限外ろ過膜(旭化成ケミカルズ製 商品名マイクローザペンシル型モジュール ACP−0013)で体積比で10倍濃縮し粗酵素を得た。
該反応液を、分画分子量13000の限外ろ過膜(旭化成ケミカルズ製 商品名マイクローザペンシル型モジュール ACP−0013)でろ過し、得られたろ液を陽・陰イオン交換樹脂で脱イオン処理し、70℃、減圧下で蒸留し、20倍の糖濃度の水溶液を得た。
市販のセロビオース、セロトリオース、セロヘキサオース(以上Sigma Aldrich製)及びグルコース(和光純薬製)を、混合し、製造例2のセロオリゴ糖粉末を得た。得られたセロオリゴ糖粉末の糖組成を表1に記す。
1)水系分散体の組成
表2にセラミドの水系分散体の製造組成例を示す。
まず、表2に示す組成でセラミドおよび脂質成分を混合し、脂質30質量%に対し、所定濃度のセロオリゴ糖水溶液を70質量%加え、この混合物を80℃での加熱し、その後超音波処理を10分間行い、10℃で冷却を行った。この操作を4回繰り返した。
また、比較例1は、上述のセロオリゴ糖水溶液から、セロオリゴ糖を除いた精製水のみを添加し、同様にセラミド水系分散体を作成した。さらに、比較例2は、上述のセロオリゴ糖の代わりに、ラフィノース(旭化成ケミカルズ製 商品名オリゴGGF)を用い、比較例3はトレハロース(林原商事製 トレハロース)を用い、比較例4はマルチトール(林原商事製 粉末マビット)を用いて、同様にセラミド水系分散体を作成した。
3)ラメラ液晶の形成状態の観察
ラメラ液晶形成は、偏光顕微鏡にて、マルテーゼクロス像の数と大きさを目視で評価した。セロオリゴ糖を配合した各実施例は、顕微鏡観察で、セラミドのマルテーゼクロスが確認された。それに対し、セロオリゴ糖を配合していない比較例はマルテーゼクロスが確認されなかった。実施例1で得られた分散体の顕微鏡観察像を図1に、比較例で得られた顕微鏡観察像を図2に示す。上記の結果から分かるように、セロオリゴ糖を配合することによって、セラミドを水系媒体に均一に分散できることが示された。また、上記でマルテーゼクロスが確認された各実施例の組成物を目視観察した結果、セラミドの分離、離水がなく、均一に分散されていた。それに対し、比較例1は、セラミドの分離、離水が容易に確認された。
実施例1と2は、製法の異なるセロオリゴ糖を使用したものであるが、ラメラ液晶の形成性は同等であった。また、得られたセラミド組成物を密栓、80℃で12時間保存した結果、実施例2は、実施例1に対し、着色が少なかった。
実施例4および比較例1〜4で得られたセラミド水分散体を、40℃で、相対湿度15%(低湿度)、35%(常湿度)、75%(高湿度)の3種の恒温恒湿条件で、開放下で4時間保存した。保存前後で、重量を測定し、残存水分率を定量した。残存水分率が高い(20%以上あり)ほど、保存安定性が優れる。また、各保存条件の結果を比較して、残存水分率のばらつきがちいさいほど、保存安定性が優れる。
実施例4の水分残存率は、24.5%(相対湿度15%)、25.1%(相対湿度35%)、24.6(相対湿度75%)であった。また、実施例4は、保存前後で、顕微鏡観察した結果、上記の保存後も、実施例はラメラ液晶状態を維持していた。
それに対し、比較例1の水分残存率は、11.5%(相対湿度15%)、12.1%(相対湿度35%)、13.8(相対湿度75%)であり、実施例4は、低湿度、常湿度、高湿度のいずれにおいても、明らかに実施例の方が保存安定性に優れていた。
また、比較例2の水分残存率は、22.0%(相対湿度15%)、24.2%(相対湿度35%)、27.9%(相対湿度75%)であり、比較例4の水分残存率は、18.5%(相対湿度15%)、24.6%(相対湿度35%)、27.3%(相対湿度75%)でああった。比較例2、4は、高湿度下では水分残存率が高いものの、実施例は、低湿度、常湿度で水分残存率が優れていた。実施例4は、比較例2、4に対し、残存水分率のばらつきが小さく、保存安定性が優れていた。
比較例3の水分残存率は、18.2%(相対湿度15%)、16.5%(相対湿度35%)、22.1%(相対湿度75%)であり、実施例4は、低湿度、常湿度、高湿度のいずれにおいても、明らかに実施例の方が保存安定性に優れていた。
Claims (5)
- セロオリゴ糖を含有するセラミド分散剤。
- 前記セロオリゴ糖におけるセロビオース含量が70質量%以上であり、セロトリオース、セロテトラオース、セロペンタオースおよびセロヘキサオースから選ばれる1種以上の糖の含量が30質量%以下である、請求項1に記載のセラミド分散剤。
- 請求項1又は2の何れかに記載のセラミド分散剤を用いて水系媒体に分散したセラミドを含むセラミド組成物であって、セラミドに対し0.005質量%以上のセロオリゴ糖を含有することを特徴とする、セラミド組成物。
- さらに脂肪酸及び/又はステロール類を含有する、請求項3に記載のセラミド組成物。
- 皮膚バリヤ機能改善剤として用いる、請求項3又は4に記載のセラミド組成物。
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JP2020109074A (ja) * | 2019-12-03 | 2020-07-16 | ちふれホールディングス株式会社 | 液晶形成用組成物、液晶含有乳化剤及びクリーム状又はフィルム状を呈する液晶含有化粧料 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2016527254A (ja) * | 2013-07-25 | 2016-09-08 | リー エバーティング,シェリル | 表皮修復のための製剤 |
US11135184B2 (en) | 2013-07-25 | 2021-10-05 | Claridei Laboratories, Inc. | Formulations for epidermal repair |
EP3733157A1 (de) * | 2019-04-30 | 2020-11-04 | Evonik Operations GmbH | Zusammensetzung enthaltend mindestens ein ceramid, mindestens eine sphingoidbase und triethylcitrat |
JP2020109074A (ja) * | 2019-12-03 | 2020-07-16 | ちふれホールディングス株式会社 | 液晶形成用組成物、液晶含有乳化剤及びクリーム状又はフィルム状を呈する液晶含有化粧料 |
JP7219697B2 (ja) | 2019-12-03 | 2023-02-08 | ちふれホールディングス株式会社 | 液晶形成用組成物、液晶含有乳化剤及びクリーム状又はフィルム状を呈する液晶含有化粧料 |
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