JP2009155269A - 皮膚角化促進剤 - Google Patents
皮膚角化促進剤 Download PDFInfo
- Publication number
- JP2009155269A JP2009155269A JP2007335549A JP2007335549A JP2009155269A JP 2009155269 A JP2009155269 A JP 2009155269A JP 2007335549 A JP2007335549 A JP 2007335549A JP 2007335549 A JP2007335549 A JP 2007335549A JP 2009155269 A JP2009155269 A JP 2009155269A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- oil
- calcium
- acid
- keratinization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- 239000011575 calcium Substances 0.000 claims abstract description 11
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 7
- -1 calcium halide Chemical class 0.000 claims description 25
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 9
- 229910001424 calcium ion Inorganic materials 0.000 claims description 9
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims description 4
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- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 2
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- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 2
- 230000004888 barrier function Effects 0.000 abstract description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 4
- 230000032683 aging Effects 0.000 abstract description 2
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Abstract
【解決手段】(A)酪酸又はその誘導体、及び(B)カルシウムイオン供給化合物を含有する皮膚角化促進剤。
【選択図】なし
Description
従って、本発明の目的は、皮膚のバリア機能の改善、皮膚の老化防止に有用な皮膚角化促進剤を提供することにある。
(a)色素類;黄色4号、青色1号、黄色202号等の厚生省令に定められたタール色素別表I及びIIの色素、クロロフィル、リボフラビン、クロシン、紅花、アントラキノン等の食品添加物として認められている天然色素等。
(b)ビタミン類;ビタミンA、ビタミンC、ビタミンD、ビタミンE等。
(c)その他;殺菌剤、防腐剤、その他製剤上必要な成分等。
皮膚は角化とともに細胞膜を蛋白質で裏打ちしてコーニファイドエンベローブを形成していく。この折、角化とともにコーニファイドエンベローブの成分として生成される蛋白質として抗菌力を有するソラヤシンが知られている。本試験ではこのソラヤシンの遺伝子発現量を指標として、カルシウム塩と酪酸塩の組み合わせによる角化への影響を検討した。
<試験方法>
4系代目の人包皮由来ケラチノサイトを6ウェルのプレート1ウェルあたり2.25×10(superscript:5)個播種し、3日間培養(37℃、95%Air、5%CO2(subscript:2))して70%コンフルエントにする。そして、CaCl2(0.062〜0.5mM)、酪酸ナトリウム(0.03〜1mM)或は両方CaCl2(0.062〜0.5mM)と酪酸ナトリウム(0.03〜1mM)を加えて、48時間で培養する。その後、上清を捨てて、細胞を完全に溶解する。全RNAを抽出し、RNAを逆転写してcDNAを作成し、定量リアルタイムPCRを用いてソラヤシンの遺伝子発現量を検出した。
<試験結果>
結果を図1〜4に示す。
その結果、塩化カルシウム及び酪酸ナトリウム単品ではほとんどソラヤシンの遺伝子は発現していないにもかかわらず、2成分を組み合わせることによって遺伝子発現量が飛躍的に増加することが明らかとなった。
Claims (3)
- (A)酪酸又はその誘導体、及び(B)カルシウムイオン供給化合物を含有する皮膚角化促進剤。
- (A)酪酸又はその誘導体が、酪酸、酪酸塩及び酪酸エステルから選ばれるものである請求項1記載の皮膚角化促進剤。
- (B)カルシウムイオン供給化合物が、カルシウムハロゲン化物、水酸化カルシウム、無機酸カルシウム塩、及び有機酸カルシウム塩から選ばれるものである請求項1又は2記載の皮膚角化促進剤。
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JP2021066716A (ja) * | 2019-10-28 | 2021-04-30 | 学校法人星薬科大学 | アクアポリン3の発現亢進能を有する短鎖脂肪酸 |
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JP7422388B2 (ja) | 2019-10-28 | 2024-01-26 | 学校法人星薬科大学 | アクアポリン3の発現亢進能を有する短鎖脂肪酸 |
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