JP2009039101A5 - - Google Patents

Download PDF

Info

Publication number
JP2009039101A5
JP2009039101A5 JP2008179448A JP2008179448A JP2009039101A5 JP 2009039101 A5 JP2009039101 A5 JP 2009039101A5 JP 2008179448 A JP2008179448 A JP 2008179448A JP 2008179448 A JP2008179448 A JP 2008179448A JP 2009039101 A5 JP2009039101 A5 JP 2009039101A5
Authority
JP
Japan
Prior art keywords
disease
treating
preventing
disorder described
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008179448A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009039101A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2009039101A publication Critical patent/JP2009039101A/ja
Publication of JP2009039101A5 publication Critical patent/JP2009039101A5/ja
Withdrawn legal-status Critical Current

Links

JP2008179448A 1995-06-28 2008-07-09 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法 Withdrawn JP2009039101A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58995P 1995-06-28 1995-06-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP9504614A Division JPH11508771A (ja) 1995-06-28 1996-06-28 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011220536A Division JP2012070735A (ja) 1995-06-28 2011-10-04 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Publications (2)

Publication Number Publication Date
JP2009039101A JP2009039101A (ja) 2009-02-26
JP2009039101A5 true JP2009039101A5 (enExample) 2011-01-27

Family

ID=21692156

Family Applications (3)

Application Number Title Priority Date Filing Date
JP9504614A Withdrawn JPH11508771A (ja) 1995-06-28 1996-06-28 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法
JP2008179448A Withdrawn JP2009039101A (ja) 1995-06-28 2008-07-09 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法
JP2011220536A Pending JP2012070735A (ja) 1995-06-28 2011-10-04 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP9504614A Withdrawn JPH11508771A (ja) 1995-06-28 1996-06-28 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011220536A Pending JP2012070735A (ja) 1995-06-28 2011-10-04 脊椎動物のDelta遺伝子のヌクレオチドおよびタンパク質配列およびそれに基づく方法

Country Status (11)

Country Link
US (5) US6262025B1 (enExample)
EP (1) EP0861261B9 (enExample)
JP (3) JPH11508771A (enExample)
AT (1) ATE442373T1 (enExample)
AU (1) AU723939B2 (enExample)
CA (1) CA2226087C (enExample)
DE (1) DE69638023D1 (enExample)
DK (1) DK0861261T3 (enExample)
ES (1) ES2334953T3 (enExample)
PT (1) PT861261E (enExample)
WO (1) WO1997001571A1 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
AU723939B2 (en) 1995-06-28 2000-09-07 Imperial Cancer Research Technology Ltd Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
AU716889B2 (en) * 1995-11-17 2000-03-09 Asahi Kasei Kogyo Kabushiki Kaisha Differentiation-suppressive polypeptide
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
ES2275304T3 (es) * 1997-04-04 2007-06-01 Millennium Pharmaceuticals, Inc. Nuevas composiciones de delta-3 humana y usos diagnosticos y terapeuticos para las mismas.
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
US6664098B1 (en) 1997-05-14 2003-12-16 Asahi Kasei Kabushiki Kaisha Differentiation inhibitory agent
EP0996628A2 (en) * 1997-06-18 2000-05-03 ZymoGenetics Mammalian neuro-growth factor like protein
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
CA2333893A1 (en) * 1998-07-13 2000-01-20 Yale University Delta cleavage products and methods based thereon
WO2000006726A2 (en) * 1998-07-27 2000-02-10 Amgen Inc. Delta-related polypeptides
JP2002526077A (ja) * 1998-09-18 2002-08-20 ハイセック,インコーポレーテッド Egf反復を含むポリペプチドに関する方法と組成物
EP1518930B1 (en) * 1998-10-13 2007-05-30 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US8084258B2 (en) * 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20080194022A1 (en) * 2000-08-03 2008-08-14 Clarke Michael F Isolation and use of solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
JP2004536877A (ja) * 2001-07-25 2004-12-09 ロランティス リミテッド 免疫療法に用いるノッチシグナル伝達モジュレーター
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
EP1448599A2 (en) * 2001-11-14 2004-08-25 Lorantis Limited Inhibitors of the notch signalling pathway for use in the treatment of cancer
EP1537145A1 (en) * 2002-09-10 2005-06-08 Lorantis Limited Pharmaceutical compositions and medical treatments comprising notch ligand proteins
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment
JP2007516693A (ja) * 2003-06-09 2007-06-28 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン 癌の治療および診断のための組成物および方法
WO2005014854A1 (en) * 2003-08-08 2005-02-17 Licentia, Ltd. Materials and methods for colorectal cancer screening, diagnosis, and therapy
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070213266A1 (en) * 2005-09-01 2007-09-13 Vasgene Therapeutics, Inc. Methods for using and identifying modulators of Delta-like 4
US7906116B2 (en) * 2005-09-01 2011-03-15 Parkash Gill Methods for using and identifying modulators of Delta-like 4
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
DK2481756T3 (en) 2005-10-31 2017-10-09 Oncomed Pharm Inc Compositions and Methods for Diagnosing and Treating Cancer
AU2006308847C1 (en) * 2005-10-31 2012-05-10 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
SI2066694T1 (sl) * 2006-09-29 2016-02-29 Oncomed Pharmaceuticals, Inc. Sestavki in postopki za diagnosticiranje in zdravljenje raka
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
US8148147B2 (en) * 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
CN105079805A (zh) 2008-09-26 2015-11-25 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
TR201818814T4 (tr) 2009-10-16 2019-01-21 Oncomed Pharm Inc Dll4 antagonist antikorlarının ve anti-hipertansif ajanların terapötik kombinasyonu ve kullanımı.
JP2013512278A (ja) * 2009-12-01 2013-04-11 オンコメッド ファーマシューティカルズ インコーポレイテッド K−ras変異を含んだ癌を処置するための方法
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt拮抗劑及治療和篩選方法
NZ602700A (en) 2010-04-01 2014-10-31 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
EP2555782A1 (en) 2010-04-09 2013-02-13 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
CA3090548C (en) 2010-04-09 2025-09-02 Fred Hutchinson Cancer Research Center COMPOSITIONS AND METHODS FOR PROVIDING HEMATOPOIETIC FUNCTION
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
PT3485903T (pt) 2011-09-23 2023-02-17 Mereo Biopharma 5 Inc Agentes de ligação a vegf/dll4 e utilizações dos mesmos
HK1203081A1 (en) 2011-12-08 2015-10-16 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
CA2868747A1 (en) * 2012-03-29 2013-10-03 Robert J. Fleming Methods and compositions for modulating notch activity
WO2014066328A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
CA2889638A1 (en) 2012-10-31 2014-05-08 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a dll4 antagonist
US9956249B2 (en) 2013-01-08 2018-05-01 Fred Hutchinson Cancer Research Center Compositions and methods for expansion of embryonic hematopoietic stem cells
AU2014212081A1 (en) 2013-02-04 2015-08-13 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
AU2014342020C1 (en) 2013-10-31 2019-09-05 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-T effector cells, and uses thereof
ES2808153T3 (es) 2014-10-31 2021-02-25 Mereo Biopharma 5 Inc Terapia de combinación para tratamiento de enfermedad
WO2016118780A1 (en) 2015-01-21 2016-07-28 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
US11827904B2 (en) 2015-04-29 2023-11-28 Fred Hutchinson Cancer Center Modified stem cells and uses thereof
JP6985934B2 (ja) 2015-04-29 2021-12-22 フレッド ハッチンソン キャンサー リサーチ センター 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用
AU2016326609B2 (en) 2015-09-23 2023-03-09 Mereo Biopharma 5, Inc. Methods and compositions for treatment of cancer

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4795699A (en) 1987-01-14 1989-01-03 President And Fellows Of Harvard College T7 DNA polymerase
IL101728A (en) 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5856441A (en) 1991-05-03 1999-01-05 Yale University Serrate fragments and derivatives
IE20030749A1 (en) 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
WO1993012141A1 (en) 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
AU5168393A (en) 1992-09-30 1994-04-26 Yale University Therapeutic and diagnostic methods and compositions based on transducin-like enhancer of split proteins and nucleic acids
US5750652A (en) 1994-01-21 1998-05-12 Yale University Deltex proteins
AU723939B2 (en) * 1995-06-28 2000-09-07 Imperial Cancer Research Technology Ltd Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
AU716889B2 (en) * 1995-11-17 2000-03-09 Asahi Kasei Kogyo Kabushiki Kaisha Differentiation-suppressive polypeptide
AU728798B2 (en) 1995-11-22 2001-01-18 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
CA2256481A1 (en) 1996-05-31 1997-12-04 The National American Red Cross Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
WO1998017793A1 (en) 1996-10-21 1998-04-30 Hsc Research And Development Limited Partnership Fringe proteins and notch signalling
DE69733695T2 (de) 1996-11-07 2006-05-18 Lorantis Ltd. Notch-liganden zur verwendung in der immuntherapie
US20020010137A1 (en) * 1997-09-18 2002-01-24 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
ES2275304T3 (es) 1997-04-04 2007-06-01 Millennium Pharmaceuticals, Inc. Nuevas composiciones de delta-3 humana y usos diagnosticos y terapeuticos para las mismas.
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
US6664098B1 (en) 1997-05-14 2003-12-16 Asahi Kasei Kabushiki Kaisha Differentiation inhibitory agent
US6436650B1 (en) * 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6692919B1 (en) * 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
TW406393B (en) * 1997-12-01 2000-09-21 United Microelectronics Corp Method of manufacturing dielectrics and the inner-lining
CA2333893A1 (en) 1998-07-13 2000-01-20 Yale University Delta cleavage products and methods based thereon
US8084258B2 (en) * 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
WO2002059285A1 (en) 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
US20070003893A1 (en) * 2005-06-30 2007-01-04 Radek Bures Combination lighter and breath freshener dispenser

Similar Documents

Publication Publication Date Title
JP2009039101A5 (enExample)
LTC2444424I2 (lt) Pagerintos TM nanodalelės, skirtos agregacijos sąlygotų sutrikimų gydymui
CY2018030I2 (el) Φαρμακοτεχνικη μορφη 514
BRPI0814889A2 (pt) tratamento com ligantes alfa7-seletivos.
JP2010500116A5 (enExample)
BRPI0906611A2 (pt) Produtos implantáveis compreendendo nanopartículas.
BRPI0812221A2 (pt) Ácidos benzoilamino-indan-2-carboxílicos substituídos e compostos relacionados.
BRPI0816970A2 (pt) 1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
JP2006213929A5 (enExample)
BRPI0911987A2 (pt) suturas e métodos heterofuncionais codificados.
DK2205562T3 (da) 1,1,1-trifluor-2-hydroxy-3-phenylpropanderivater
BRPI0917567A2 (pt) tratamento de doença respiratória
JP2014530840A5 (enExample)
SI2432798T1 (sl) Derivat 17-hidroksi-17-pentafluoretil-estra-4,9(10)-dien-11-arila, postopki izdelave in uporaba pri zdravljenju bolezni
EP2206505A4 (en) Nano-level lactic acid bacterium
FI20085782A0 (fi) Kartonkikone
DE602007001681D1 (de) 1,3-dioxan-carboxylsäuren
DK2173831T3 (da) Brøndbehandling
BRPI0820440A2 (pt) Inibidores aldh-2 no tratamento de desordens psiquiátricas
BRPI0822129A2 (pt) Inibidores de aldh-2c no tratamento de vício.
ATE531715T1 (de) 1,3-dihydro-2h-pyrroloä3.2-büpyridin-2-onderiva e,deren herstellung und deren therapeutische verwendungen
BRPI0811266A2 (pt) Método de acupuntura e uma agulha para realizar o mesmo.
JP2008533990A5 (enExample)
FI20080124A0 (fi) Läheis-Josephson-ilmaisin
JP2008519810A5 (enExample)