JP2008546679A5 - - Google Patents
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- Publication number
- JP2008546679A5 JP2008546679A5 JP2008516452A JP2008516452A JP2008546679A5 JP 2008546679 A5 JP2008546679 A5 JP 2008546679A5 JP 2008516452 A JP2008516452 A JP 2008516452A JP 2008516452 A JP2008516452 A JP 2008516452A JP 2008546679 A5 JP2008546679 A5 JP 2008546679A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- alkynyl
- cycloalkenyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 34
- 125000003342 alkenyl group Chemical group 0.000 claims description 23
- 125000000304 alkynyl group Chemical group 0.000 claims description 23
- 229910052757 nitrogen Inorganic materials 0.000 claims description 17
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 125000005842 heteroatom Chemical group 0.000 claims description 11
- 150000002431 hydrogen Chemical class 0.000 claims description 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 239000011593 sulfur Substances 0.000 claims description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 239000012458 free base Substances 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- -1 oxy compound Chemical class 0.000 claims 2
- 239000002585 base Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69200905P | 2005-06-17 | 2005-06-17 | |
| US60/692,009 | 2005-06-17 | ||
| PCT/IB2006/002785 WO2006134499A2 (en) | 2005-06-17 | 2006-06-14 | 2-(1h-indolylsulfanyl)-aryl amine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008546679A JP2008546679A (ja) | 2008-12-25 |
| JP2008546679A5 true JP2008546679A5 (https=) | 2012-04-12 |
| JP5144507B2 JP5144507B2 (ja) | 2013-02-13 |
Family
ID=37532681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008516452A Expired - Fee Related JP5144507B2 (ja) | 2005-06-17 | 2006-06-14 | ２−（１ｈ−インドリルスルファニル）−アリールアミン誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1893575B1 (https=) |
| JP (1) | JP5144507B2 (https=) |
| KR (1) | KR20080027462A (https=) |
| CN (1) | CN101238101A (https=) |
| AR (1) | AR054394A1 (https=) |
| AU (1) | AU2006257288A1 (https=) |
| BR (1) | BRPI0611748A2 (https=) |
| CA (1) | CA2611566C (https=) |
| EA (1) | EA200800070A1 (https=) |
| ES (1) | ES2616095T3 (https=) |
| IL (1) | IL188064A0 (https=) |
| MX (1) | MX2007014954A (https=) |
| NO (1) | NO20080265L (https=) |
| WO (1) | WO2006134499A2 (https=) |
| ZA (1) | ZA200710885B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101868233A (zh) * | 2007-09-24 | 2010-10-20 | H.隆德贝克有限公司 | 与血清素双重作用化合物有关的组合疗法 |
| TW200938189A (en) * | 2008-03-13 | 2009-09-16 | Lundbeck & Co As H | [2-(6-flouro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders |
| US9000025B2 (en) | 2010-08-20 | 2015-04-07 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| US9260416B2 (en) | 2011-05-27 | 2016-02-16 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| CA2900604A1 (en) * | 2013-03-15 | 2014-09-25 | Chromocell Corporation | Sodium channel modulators for the treatment of pain |
| JP2016530210A (ja) | 2013-09-17 | 2016-09-29 | ファーマケア，インク． | ヘテロ環式ビニルオートタキシン阻害剤化合物 |
| US9714240B2 (en) | 2013-09-17 | 2017-07-25 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| JP2016531874A (ja) | 2013-09-26 | 2016-10-13 | ファーマケア，インク． | オートタキシン阻害剤化合物 |
| KR102515248B1 (ko) | 2013-11-22 | 2023-03-29 | 사브레 테라퓨틱스 엘엘씨 | 오토탁신 억제제 화합물 |
| MX2017015225A (es) | 2015-05-27 | 2018-02-19 | Pharmakea Inc | Inhibidores de la autotaxina y sus usos. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117129A (en) * | 1976-10-22 | 1978-09-26 | Warner-Lambert Company | Indolobenzoxazepines as cns depressants |
| ATE195125T1 (de) * | 1995-11-06 | 2000-08-15 | Dsm Nv | Verfahren zur de-esterifikation |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| TW200400177A (en) * | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| RS50589B (sr) * | 2003-12-23 | 2010-05-07 | H. Lundbeck A/S. | 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
-
2006
- 2006-06-13 AR ARP060102491A patent/AR054394A1/es not_active Application Discontinuation
- 2006-06-14 AU AU2006257288A patent/AU2006257288A1/en not_active Abandoned
- 2006-06-14 EA EA200800070A patent/EA200800070A1/ru unknown
- 2006-06-14 ES ES06808965.5T patent/ES2616095T3/es active Active
- 2006-06-14 ZA ZA200710885A patent/ZA200710885B/xx unknown
- 2006-06-14 BR BRPI0611748A patent/BRPI0611748A2/pt not_active IP Right Cessation
- 2006-06-14 EP EP06808965.5A patent/EP1893575B1/en active Active
- 2006-06-14 MX MX2007014954A patent/MX2007014954A/es not_active Application Discontinuation
- 2006-06-14 CN CNA2006800218382A patent/CN101238101A/zh active Pending
- 2006-06-14 KR KR1020077029334A patent/KR20080027462A/ko not_active Withdrawn
- 2006-06-14 JP JP2008516452A patent/JP5144507B2/ja not_active Expired - Fee Related
- 2006-06-14 CA CA2611566A patent/CA2611566C/en not_active Expired - Fee Related
- 2006-06-14 WO PCT/IB2006/002785 patent/WO2006134499A2/en not_active Ceased
-
2007
- 2007-12-11 IL IL188064A patent/IL188064A0/en unknown
-
2008
- 2008-01-15 NO NO20080265A patent/NO20080265L/no not_active Application Discontinuation
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