JP2008545786A5 - - Google Patents
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- Publication number
- JP2008545786A5 JP2008545786A5 JP2008515881A JP2008515881A JP2008545786A5 JP 2008545786 A5 JP2008545786 A5 JP 2008545786A5 JP 2008515881 A JP2008515881 A JP 2008515881A JP 2008515881 A JP2008515881 A JP 2008515881A JP 2008545786 A5 JP2008545786 A5 JP 2008545786A5
- Authority
- JP
- Japan
- Prior art keywords
- base
- lower alkyl
- metal
- organic solvent
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- WWTGXYAJVXKEKL-UHFFFAOYSA-N 3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)aniline Chemical compound C1=NC(C)=CN1C1=CC(N)=CC(C(F)(F)F)=C1 WWTGXYAJVXKEKL-UHFFFAOYSA-N 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 150000004703 alkoxides Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical class C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 claims 1
- 229910052987 metal hydride Inorganic materials 0.000 claims 1
- 150000004681 metal hydrides Chemical class 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical group [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 0 *c(ccc(C(N(*)*)=O)c1)c1Nc1nc(-c2cnccc2)ccn1 Chemical compound *c(ccc(C(N(*)*)=O)c1)c1Nc1nc(-c2cnccc2)ccn1 0.000 description 2
- BECBKQYLJDEVDN-UHFFFAOYSA-N Cc(c(Nc1nc(-c2cnccc2)ccn1)c1)ccc1C(OC)=O Chemical compound Cc(c(Nc1nc(-c2cnccc2)ccn1)c1)ccc1C(OC)=O BECBKQYLJDEVDN-UHFFFAOYSA-N 0.000 description 1
- HHZIURLSWUIHRB-UHFFFAOYSA-N Cc(nc1)c[n]1-c1cc(NC(c2ccc(C)c(Nc3nc(-c4cnccc4)ccn3)c2)=O)cc(C(F)(F)F)c1 Chemical compound Cc(nc1)c[n]1-c1cc(NC(c2ccc(C)c(Nc3nc(-c4cnccc4)ccn3)c2)=O)cc(C(F)(F)F)c1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68897705P | 2005-06-09 | 2005-06-09 | |
| US60/688,977 | 2005-06-09 | ||
| US70559005P | 2005-08-04 | 2005-08-04 | |
| US60/705,590 | 2005-08-04 | ||
| PCT/US2006/022155 WO2006135641A2 (en) | 2005-06-09 | 2006-06-07 | PROCESS FOR THE SYNTHESIS OF 5- (METHYL-lH-IMIDAZOL-l-YL) -3- (TRI FLUOROME TH YL) -BENZENEAMINE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008545786A JP2008545786A (ja) | 2008-12-18 |
| JP2008545786A5 true JP2008545786A5 (enExample) | 2009-07-23 |
| JP5118024B2 JP5118024B2 (ja) | 2013-01-16 |
Family
ID=37091153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515881A Active JP5118024B2 (ja) | 2005-06-09 | 2006-06-07 | 有機化合物の合成方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8124763B2 (enExample) |
| EP (1) | EP1924574B1 (enExample) |
| JP (1) | JP5118024B2 (enExample) |
| KR (3) | KR20120066067A (enExample) |
| AR (1) | AR053890A1 (enExample) |
| AT (1) | ATE487709T1 (enExample) |
| AU (1) | AU2006258051B2 (enExample) |
| BR (1) | BRPI0611663A2 (enExample) |
| CA (1) | CA2610105C (enExample) |
| CY (1) | CY1111428T1 (enExample) |
| DE (1) | DE602006018156D1 (enExample) |
| DK (1) | DK1924574T3 (enExample) |
| EC (1) | ECSP077982A (enExample) |
| EG (1) | EG25039A (enExample) |
| GT (1) | GT200600217A (enExample) |
| IL (1) | IL187421A (enExample) |
| JO (1) | JO2636B1 (enExample) |
| MA (1) | MA29599B1 (enExample) |
| MX (1) | MX2007015423A (enExample) |
| MY (1) | MY147436A (enExample) |
| NO (1) | NO340743B1 (enExample) |
| NZ (1) | NZ563740A (enExample) |
| PE (1) | PE20070015A1 (enExample) |
| PL (1) | PL1924574T3 (enExample) |
| PT (1) | PT1924574E (enExample) |
| RU (1) | RU2444520C2 (enExample) |
| SA (1) | SA06270147B1 (enExample) |
| SI (1) | SI1924574T1 (enExample) |
| TN (1) | TNSN07463A1 (enExample) |
| TW (1) | TWI430999B (enExample) |
| WO (1) | WO2006135641A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200600316A (es) * | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| TWI433677B (zh) | 2007-06-04 | 2014-04-11 | Avila Therapeutics Inc | 雜環化合物及其用途 |
| US20100016590A1 (en) * | 2008-07-17 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Nilotinib intermediates and preparation thereof |
| EP2530081A3 (en) | 2008-11-05 | 2013-04-10 | Teva Pharmaceutical Industries, Ltd. | Nilotinib HCI crystalline forms |
| WO2010060074A1 (en) * | 2008-11-24 | 2010-05-27 | Teva Pharmaceutical Industries Ltd. | Preparation of nilotinib and intermediates thereof |
| US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| JO3634B1 (ar) | 2009-11-17 | 2020-08-27 | Novartis Ag | طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r |
| WO2012135651A1 (en) | 2011-03-31 | 2012-10-04 | The Procter & Gamble Company | Systems, models and methods for identifying and evaluating skin-active agents effective for treating dandruff/seborrheic dermatitis |
| AR086913A1 (es) * | 2011-06-14 | 2014-01-29 | Novartis Ag | 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas |
| WO2013120852A1 (en) | 2012-02-13 | 2013-08-22 | Grindeks, A Joint Stock Company | Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors |
| US9920357B2 (en) | 2012-06-06 | 2018-03-20 | The Procter & Gamble Company | Systems and methods for identifying cosmetic agents for hair/scalp care compositions |
| WO2015092624A1 (en) | 2013-12-16 | 2015-06-25 | Ranbaxy Laboratories Limited | Nilotinib mono-oxalate and its crystalline form |
| CN103694176B (zh) | 2014-01-07 | 2015-02-18 | 苏州立新制药有限公司 | 尼洛替尼中间体的制备方法 |
| EP3095782A1 (en) | 2015-05-18 | 2016-11-23 | Esteve Química, S.A. | New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| EP3806858A4 (en) | 2018-06-15 | 2022-03-09 | Handa Pharmaceuticals, Inc. | KINA INHIBITOR SALTS AND COMPOSITIONS THEREOF |
| JP2020007240A (ja) * | 2018-07-04 | 2020-01-16 | 住友化学株式会社 | ベンズアミド化合物の製造方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5136082A (en) * | 1990-08-03 | 1992-08-04 | Himont Incorporated | Process for preparing organic esters and amides and catalyst system therefor |
| AU5539294A (en) | 1992-12-24 | 1994-07-19 | Hemagen/Pfc | Fluorocarbon emulsions |
| TW406020B (en) | 1993-09-29 | 2000-09-21 | Bristol Myers Squibb Co | Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent |
| US5597829A (en) | 1994-05-09 | 1997-01-28 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of camptothecin and methods for uses thereof |
| US5726181A (en) | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| US6323366B1 (en) | 1997-07-29 | 2001-11-27 | Massachusetts Institute Of Technology | Arylamine synthesis |
| AR013261A1 (es) | 1997-08-01 | 2000-12-13 | Smithkline Beecham Corp | Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina |
| US20030059465A1 (en) | 1998-05-11 | 2003-03-27 | Unger Evan C. | Stabilized nanoparticle formulations of camptotheca derivatives |
| US6395916B1 (en) * | 1998-07-10 | 2002-05-28 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| EP1044977B1 (en) | 1999-03-09 | 2002-05-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Camptothecin derivatives having antitumor activity |
| IT1306129B1 (it) | 1999-04-13 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti |
| DE19926056B4 (de) | 1999-06-08 | 2004-03-25 | Gkss-Forschungszentrum Geesthacht Gmbh | Einrichtung zur Analyse atomarer und/oder molekularer Elemente mittels wellenlängendispersiver, röntgenspektrometrischer Einrichtungen |
| GB9918885D0 (en) | 1999-08-10 | 1999-10-13 | Pharmacia & Upjohn Spa | Pharmaceutical formulations in hydroxypropymethycellulose capsules |
| GB9925127D0 (en) | 1999-10-22 | 1999-12-22 | Pharmacia & Upjohn Spa | Oral formulations for anti-tumor compounds |
| US20040009229A1 (en) | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
| US20020150615A1 (en) | 2001-02-12 | 2002-10-17 | Howard Sands | Injectable pharmaceutical composition comprising microdroplets of a camptothecin |
| US6629598B2 (en) | 2001-08-10 | 2003-10-07 | Vinod K. Narula | Flexible ribbed splint system |
| US6653319B1 (en) | 2001-08-10 | 2003-11-25 | University Of Kentucky Research Foundation | Pharmaceutical formulation for poorly water soluble camptothecin analogues |
| WO2003032906A2 (en) | 2001-10-15 | 2003-04-24 | Crititech, Inc. | Delivery of poorly soluble drugs |
| AU2002353118A1 (en) | 2001-12-11 | 2003-07-24 | Dor Biopharma, Inc. | Lipid particles and suspensions and uses thereof |
| JP2003267891A (ja) | 2002-03-13 | 2003-09-25 | Mitsubishi-Kagaku Foods Corp | Ｗ／ｏ／ｗ型エマルション製剤 |
| FR2840303B1 (fr) * | 2002-05-31 | 2005-07-15 | Rhodia Chimie Sa | Procede d'arylation ou de vinylation ou d'alcylynation d'un compose nucleophile |
| CZ294371B6 (cs) | 2002-06-10 | 2004-12-15 | Pliva - Lachema, A. S. | Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy |
| EP1393719A1 (en) | 2002-08-23 | 2004-03-03 | Munich Biotech AG | Camptothecin-carboxylate formulations |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| JP4426749B2 (ja) | 2002-07-11 | 2010-03-03 | 株式会社産学連携機構九州 | Ｏ／ｗ型エマルション製剤 |
| US20040171560A1 (en) | 2002-12-23 | 2004-09-02 | Dabur Research Foundation | Stabilized pharmaceutical composition |
| JP2006199590A (ja) | 2003-09-04 | 2006-08-03 | Nano Career Kk | 水溶性の塩基性薬物内包ナノ粒子含有組成物 |
| CA2543722C (en) | 2003-10-29 | 2011-01-04 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| CA2548078C (en) | 2003-12-17 | 2009-05-12 | Bionumerik Pharmaceuticals, Inc. | Pharmaceutical formulations of camptothecins and process for making same |
| GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos |
-
2006
- 2006-05-23 SA SA06270147A patent/SA06270147B1/ar unknown
- 2006-05-24 GT GT200600217A patent/GT200600217A/es unknown
- 2006-05-31 MY MYPI20062507A patent/MY147436A/en unknown
- 2006-06-06 JO JO2006166A patent/JO2636B1/en active
- 2006-06-07 AT AT06772448T patent/ATE487709T1/de active
- 2006-06-07 JP JP2008515881A patent/JP5118024B2/ja active Active
- 2006-06-07 WO PCT/US2006/022155 patent/WO2006135641A2/en not_active Ceased
- 2006-06-07 MX MX2007015423A patent/MX2007015423A/es active IP Right Grant
- 2006-06-07 PT PT06772448T patent/PT1924574E/pt unknown
- 2006-06-07 US US11/915,671 patent/US8124763B2/en active Active
- 2006-06-07 KR KR1020127011980A patent/KR20120066067A/ko not_active Ceased
- 2006-06-07 SI SI200630903T patent/SI1924574T1/sl unknown
- 2006-06-07 DE DE602006018156T patent/DE602006018156D1/de active Active
- 2006-06-07 PL PL06772448T patent/PL1924574T3/pl unknown
- 2006-06-07 CA CA2610105A patent/CA2610105C/en active Active
- 2006-06-07 AR ARP060102369A patent/AR053890A1/es not_active Application Discontinuation
- 2006-06-07 KR KR1020137025659A patent/KR101514593B1/ko active Active
- 2006-06-07 BR BRPI0611663-9A patent/BRPI0611663A2/pt not_active Application Discontinuation
- 2006-06-07 EP EP06772448A patent/EP1924574B1/en active Active
- 2006-06-07 NZ NZ563740A patent/NZ563740A/en not_active IP Right Cessation
- 2006-06-07 RU RU2007148231/04A patent/RU2444520C2/ru active
- 2006-06-07 KR KR1020077028638A patent/KR101216249B1/ko active Active
- 2006-06-07 PE PE2006000631A patent/PE20070015A1/es not_active Application Discontinuation
- 2006-06-07 DK DK06772448.4T patent/DK1924574T3/da active
- 2006-06-07 AU AU2006258051A patent/AU2006258051B2/en active Active
- 2006-06-08 TW TW095120302A patent/TWI430999B/zh not_active IP Right Cessation
-
2007
- 2007-11-15 IL IL187421A patent/IL187421A/en active IP Right Grant
- 2007-12-05 EC EC2007007982A patent/ECSP077982A/es unknown
- 2007-12-07 TN TNP2007000463A patent/TNSN07463A1/en unknown
- 2007-12-09 EG EGNA2007001382 patent/EG25039A/xx active
- 2007-12-26 MA MA30505A patent/MA29599B1/fr unknown
-
2008
- 2008-01-09 NO NO20080157A patent/NO340743B1/no unknown
-
2011
- 2011-02-04 CY CY20111100134T patent/CY1111428T1/el unknown
-
2012
- 2012-01-19 US US13/353,434 patent/US8946416B2/en active Active
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