JP2008543972A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008543972A5 JP2008543972A5 JP2008519471A JP2008519471A JP2008543972A5 JP 2008543972 A5 JP2008543972 A5 JP 2008543972A5 JP 2008519471 A JP2008519471 A JP 2008519471A JP 2008519471 A JP2008519471 A JP 2008519471A JP 2008543972 A5 JP2008543972 A5 JP 2008543972A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- occurrence
- independently
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 106
- 125000000623 heterocyclic group Chemical group 0.000 claims 77
- 229910052760 oxygen Inorganic materials 0.000 claims 65
- 125000004432 carbon atoms Chemical group C* 0.000 claims 60
- 125000005842 heteroatoms Chemical group 0.000 claims 50
- 229910052717 sulfur Inorganic materials 0.000 claims 48
- 229910052799 carbon Inorganic materials 0.000 claims 44
- 229920000728 polyester Polymers 0.000 claims 32
- 229910052731 fluorine Inorganic materials 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 29
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 28
- 229910052801 chlorine Inorganic materials 0.000 claims 27
- 125000003118 aryl group Chemical group 0.000 claims 24
- 229910052794 bromium Inorganic materials 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000002837 carbocyclic group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 13
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 13
- -1 4,4,5,5- tetramethyl 1,3,2 dioxaborolanyl Chemical group 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 9
- 125000004429 atoms Chemical group 0.000 claims 9
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 8
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 229910052710 silicon Inorganic materials 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 235000019000 fluorine Nutrition 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000006217 methyl sulfide group Chemical group [H]C([H])([H])S* 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrugs Drugs 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 208000005189 Embolism Diseases 0.000 claims 2
- 208000010125 Myocardial Infarction Diseases 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010003658 Atrial fibrillation Diseases 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 206010008088 Cerebral artery embolism Diseases 0.000 claims 1
- 206010008092 Cerebral artery thrombosis Diseases 0.000 claims 1
- 208000002528 Coronary Thrombosis Diseases 0.000 claims 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 229910004673 OPr Inorganic materials 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 206010062585 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 206010044390 Transient ischaemic attack Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 206010047249 Venous thrombosis Diseases 0.000 claims 1
- 201000001320 atherosclerosis Diseases 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000000271 cardiovascular Effects 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 201000010849 intracranial embolism Diseases 0.000 claims 1
- 230000000302 ischemic Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000414 obstructive Effects 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 230000003836 peripheral circulation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 230000000306 recurrent Effects 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 201000005060 thrombophlebitis Diseases 0.000 claims 1
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 1
- 0 NC(*=Cc1ccccc1)=O Chemical compound NC(*=Cc1ccccc1)=O 0.000 description 10
- POTIYWUALSJREP-UHFFFAOYSA-O C(CC1)CC2C1[NH2+]CCC2 Chemical compound C(CC1)CC2C1[NH2+]CCC2 POTIYWUALSJREP-UHFFFAOYSA-O 0.000 description 1
- YRLORWPBJZEGBX-UHFFFAOYSA-N C1Nc(cccc2)c2OC1 Chemical compound C1Nc(cccc2)c2OC1 YRLORWPBJZEGBX-UHFFFAOYSA-N 0.000 description 1
- YBBLSBDJIKMXNQ-UHFFFAOYSA-N C1Nc(cccc2)c2SC1 Chemical compound C1Nc(cccc2)c2SC1 YBBLSBDJIKMXNQ-UHFFFAOYSA-N 0.000 description 1
- FUABVWOOSMWJLQ-UHFFFAOYSA-N C1Nc(cccc2)c2[SiH+]C1 Chemical compound C1Nc(cccc2)c2[SiH+]C1 FUABVWOOSMWJLQ-UHFFFAOYSA-N 0.000 description 1
- SKEPYJIOOUMIOM-UHFFFAOYSA-N CCC(CCCC1)C1NI Chemical compound CCC(CCCC1)C1NI SKEPYJIOOUMIOM-UHFFFAOYSA-N 0.000 description 1
- DEOHVFJWJUKWLC-UHFFFAOYSA-N CNC1C(CCI)CCCC1 Chemical compound CNC1C(CCI)CCCC1 DEOHVFJWJUKWLC-UHFFFAOYSA-N 0.000 description 1
- UJOBWOGCFQCDNV-UHFFFAOYSA-N c(cc1)cc2c1[nH]c1c2cccc1 Chemical compound c(cc1)cc2c1[nH]c1c2cccc1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69459605P | 2005-06-27 | 2005-06-27 | |
| US79706406P | 2006-05-02 | 2006-05-02 | |
| PCT/US2006/024914 WO2007002637A1 (en) | 2005-06-27 | 2006-06-26 | N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008543972A JP2008543972A (ja) | 2008-12-04 |
| JP2008543972A5 true JP2008543972A5 (US07585860-20090908-C00112.png) | 2009-08-13 |
Family
ID=37087734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519471A Pending JP2008543972A (ja) | 2005-06-27 | 2006-06-26 | 血栓症状の治療に有用なｐ２ｙ１受容体のｎ−結合複素環式アンタゴニスト |
Country Status (13)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| JP2008527043A (ja) * | 2005-01-19 | 2008-07-24 | ブリストル−マイヤーズ スクイブ カンパニー | 血栓塞栓障害治療用のｐ２ｙ１受容体阻害剤としての２−フェノキシ−ｎ−（１，３，４−チアジアゾール−２−イル）ピリジン−３−アミン誘導体および関連化合物 |
| EP1899299B1 (en) * | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| ATE502924T1 (de) | 2005-06-27 | 2011-04-15 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden |
| US7714002B2 (en) * | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| US7960569B2 (en) * | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| AU2011255218B2 (en) | 2010-05-21 | 2015-03-12 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| CA2842190A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| AR091790A1 (es) | 2011-08-29 | 2015-03-04 | Infinity Pharmaceuticals Inc | Derivados de isoquinolin-1-ona y sus usos |
| US9540323B2 (en) | 2012-08-01 | 2017-01-10 | Bristol-Myers Squibb Company | 7-hydroxy-indolinyl antagonists of P2Y1 receptor |
| EP2892898B1 (en) * | 2012-08-01 | 2016-05-25 | Bristol-Myers Squibb Company | 7-hydroxy-spiropipiperidine indolinyl antagonists of p2y1 receptor |
| WO2014022253A1 (en) * | 2012-08-01 | 2014-02-06 | Bristol-Myers Squibb Company | Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of p2y1 receptor |
| KR20150087400A (ko) | 2012-11-20 | 2015-07-29 | 버텍스 파마슈티칼스 인코포레이티드 | 인돌아민 2,3-디옥시게나제의 억제제로서 유용한 화합물 |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| SG11202102679QA (en) | 2018-09-18 | 2021-04-29 | Nikang Therapeutics Inc | Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3118888A (en) | 1964-01-21 | Acylated s-triazines and process for their preparation | ||
| NL280954A (US07585860-20090908-C00112.png) | 1961-07-14 | |||
| US4179563A (en) | 1978-05-19 | 1979-12-18 | Warner-Lambert Company | 3-Aryloxy-substituted-aminopyridines and methods for their production |
| US4186199A (en) * | 1978-11-02 | 1980-01-29 | American Hoechst Corporation | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines |
| DE3065190D1 (en) | 1979-11-05 | 1983-11-10 | Beecham Group Plc | Enzyme derivatives, and their preparation |
| JPS56166180A (en) | 1980-05-28 | 1981-12-21 | Chugai Pharmaceut Co Ltd | Dibenzoxazepine derivative and its preparation |
| JPS56167649A (en) | 1980-05-30 | 1981-12-23 | Chugai Pharmaceut Co Ltd | Diphenyl ether derivative |
| US4761411A (en) * | 1983-05-18 | 1988-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
| US4663453A (en) | 1983-05-18 | 1987-05-05 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepines having dopamine receptor activity |
| JPS62280847A (ja) | 1986-05-30 | 1987-12-05 | Konica Corp | 新規なマゼンタカプラ−を含有するハロゲン化銀写真感光材料 |
| US4840947A (en) | 1986-10-14 | 1989-06-20 | Hoechst-Roussel Pharmaceuticals, Inc. | Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas |
| JP2577222B2 (ja) | 1987-04-10 | 1997-01-29 | 興和株式会社 | 新規な置換アニリド誘導体 |
| JPH0339740A (ja) | 1989-07-06 | 1991-02-20 | Konica Corp | 転写型熱現像カラー感光材料 |
| JP2951434B2 (ja) | 1991-04-18 | 1999-09-20 | 三菱製紙株式会社 | 電子写真感光体 |
| NZ264063A (en) | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| JP3395285B2 (ja) | 1993-10-06 | 2003-04-07 | 日本製紙株式会社 | 感熱記録体 |
| US5547966A (en) | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| DE4443641A1 (de) | 1994-12-08 | 1996-06-13 | Bayer Ag | Substituierte Carbonsäureamide |
| JPH11503110A (ja) | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| PL322843A1 (en) | 1995-03-20 | 1998-02-16 | Lilly Co Eli | 5-substituted 3-91,2,3,6-tetrahydropyridin-4-yl)- and 3-9piperydin-4-4-yl0-1h-indoles nevel 5-htif natagonists |
| AU7340096A (en) | 1995-11-07 | 1997-05-29 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same |
| EA199800867A1 (ru) | 1996-03-25 | 1999-02-25 | Эли Лилли Энд Компани | Соединения тетрагидробетакарболина |
| AU5584698A (en) | 1996-10-30 | 1998-05-22 | University Of North Carolina At Chapel Hill, The | P2y receptor antagonists |
| US6187797B1 (en) | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
| US6020357A (en) | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| US5858289A (en) | 1997-02-24 | 1999-01-12 | Global Consulting, Inc. | Process for preparing compressed shape of ceramic fiber |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| CA2309319A1 (en) | 1997-11-10 | 1999-05-20 | Bristol-Myers Squibb Company | Benzothiazole protein tyrosine kinase inhibitors |
| CA2313125A1 (en) | 1997-12-12 | 1999-06-24 | Laramie Mary Gaster | Quinolinepiperazine and quinolinepiperidine derivatives, their preparation and their use as combined 5-ht1a, 5-ht1b and 5-ht1d receptor antagonists |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| CA2315715C (en) | 1997-12-22 | 2010-06-22 | Bayer Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US6329395B1 (en) | 1998-06-08 | 2001-12-11 | Schering Corporation | Neuropeptide Y5 receptor antagonists |
| AU767456B2 (en) | 1998-07-06 | 2003-11-13 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| ATE287875T1 (de) | 1998-10-06 | 2005-02-15 | Dainippon Pharmaceutical Co | 2,3-disubstituierte pyridinderivate, verfahren zur derren herstellung, sie enthaltende wirkstoffzubereitungen und zwischenprodukte für die herstellung |
| ATE290524T1 (de) | 1998-10-20 | 2005-03-15 | Takeda Pharmaceutical | Aromatische aminderivate, verfahren zu ihrer herstellung und mittel, die diese enthalten |
| GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| ATE278674T1 (de) | 1999-03-12 | 2004-10-15 | Boehringer Ingelheim Pharma | Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel |
| US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
| RU2260592C9 (ru) | 1999-04-15 | 2017-04-07 | Бристол-Маерс Сквибб Ко. | Циклические ингибиторы протеинтирозинкиназ |
| AU5413600A (en) | 1999-06-14 | 2001-01-02 | Eli Lilly And Company | Compounds |
| CO5200760A1 (es) | 1999-06-16 | 2002-09-27 | Smithkline Beecham Corp | Antagonistas del receptor de la il-8 ceptor il-8 |
| JP2001089412A (ja) | 1999-09-22 | 2001-04-03 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体またはその医薬的に許容される塩 |
| WO2001023358A1 (fr) | 1999-09-27 | 2001-04-05 | Sagami Chemical Research Center | Derives pyrazole, intermediaires pour la preparation de ces derives, procedes de preparation des derives et intermediaires, et herbicides dont ces derives sont le principe actif |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| ATE336492T1 (de) | 2000-01-14 | 2006-09-15 | Us Gov Health & Human Serv | Methonocarbacycloalkylanaloga von nucleosiden |
| EP1254136A4 (en) | 2000-01-29 | 2005-06-01 | Lg Chem Investment Ltd | ARYLAMIDINES AND DERIVATIVES AS FACTOR XA INHIBITORS AND THEIR PRO-PHARMAKA |
| US6906063B2 (en) * | 2000-02-04 | 2005-06-14 | Portola Pharmaceuticals, Inc. | Platelet ADP receptor inhibitors |
| PL357099A1 (en) | 2000-02-07 | 2004-07-12 | Abbott Gmbh & Co.Kg | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
| WO2001072751A1 (en) | 2000-03-29 | 2001-10-04 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
| WO2001074793A2 (en) | 2000-04-03 | 2001-10-11 | 3-Dimensional Pharmaceuticals, Inc. | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 |
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| CN1486170A (zh) | 2001-01-31 | 2004-03-31 | P&G | 用于氧化性染发的新的偶合剂 |
| WO2002064211A1 (en) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
| AU2002305260A1 (en) | 2001-04-27 | 2002-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazole derived kinase inhibitors |
| MXPA03010099A (es) | 2001-05-08 | 2004-03-10 | Schering Ag | Amidas de antranilamida-piridina selectivas como inhibidores de vegfr-2 y vegfr-3. |
| AU2002317377A1 (en) | 2001-07-20 | 2003-03-03 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
| JP2005501873A (ja) | 2001-07-31 | 2005-01-20 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | アミン誘導体 |
| CZ2004168A3 (cs) | 2001-08-06 | 2004-05-12 | Pharmaciaáitaliaás@P@A | Aminoizoxazolové derivátyŹ účinné jako kinázové inhibitoryŹ způsob jejich přípravy a farmaceutické prostředkyŹ které je obsahují |
| BRPI0212726B8 (pt) | 2001-09-21 | 2021-05-25 | Bristol Myers Squibb Co | compostos contendo lactamas, e derivados dos mesmos, composição farmacêutica que os compreende e seus usos |
| WO2003045920A1 (en) | 2001-11-27 | 2003-06-05 | Merck & Co., Inc. | 4-aminoquinoline compounds |
| JP2003192587A (ja) | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| EP1461311A2 (en) | 2001-12-26 | 2004-09-29 | Bayer HealthCare AG | Urea derivatives as vr1-antagonists |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| EP1478358B1 (en) | 2002-02-11 | 2013-07-03 | Bayer HealthCare LLC | Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis |
| WO2003068223A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
| DE10213228A1 (de) | 2002-03-25 | 2003-10-16 | Bayer Ag | Cyclopenten-Derivate |
| CA2485429A1 (en) | 2002-05-06 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Thiadiazoles or oxadiazoles and their use as inhibitors of jak protein kinase |
| MXPA05000130A (es) | 2002-06-27 | 2005-02-17 | Novo Nordisk As | Derivados de aril-carbonilo como agentes terapeuticos. |
| PL375318A1 (en) | 2002-08-01 | 2005-11-28 | Neurosearch A/S | Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy |
| US20060160856A1 (en) | 2002-09-05 | 2006-07-20 | Dahl Bjarne H | Diarylurea derivatives and their use as chloride channel blockers |
| EP1402888A1 (en) | 2002-09-18 | 2004-03-31 | Jerini AG | The use of substituted carbocyclic compounds as rotamases inhibitors |
| US20040209930A1 (en) | 2002-10-02 | 2004-10-21 | Carboni Joan M. | Synergistic methods and compositions for treating cancer |
| WO2004046090A2 (en) | 2002-11-21 | 2004-06-03 | Neurosearch A/S | Aryl ureido derivatives and their medical use |
| US7056889B2 (en) | 2002-12-16 | 2006-06-06 | Kimberly-Clark, Worldwide, Inc. | Compounds that bind P2Y2 or P2Y1 receptors |
| TWM252710U (en) | 2003-07-18 | 2004-12-11 | Huei-Chiun Shiu | Annealing equipment |
| US20100267778A1 (en) | 2003-08-04 | 2010-10-21 | Shinya Kusuda | Diphenyl ether compound, process for producing the same, and use |
| WO2005019240A2 (en) | 2003-08-13 | 2005-03-03 | Amgen, Inc. | Melanin concentrating hormone receptor antagonists |
| JP4771468B2 (ja) | 2003-12-26 | 2011-09-14 | 正敏 萩原 | Ｓｒ蛋白質のリン酸化制御方法、および、ｓｒ蛋白質の活性制御剤を有効成分とする抗ウイルス剤 |
| US7470712B2 (en) | 2004-01-21 | 2008-12-30 | Bristol-Myers Squibb Company | Amino-benzazoles as P2Y1 receptor inhibitors |
| US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| KR20070032648A (ko) | 2004-05-12 | 2007-03-22 | 브리스톨-마이어스 스큅 컴퍼니 | 혈전 상태의 치료에 유용한 ｐ２ｙ１ 수용체의 우레아길항제 |
| JP2008527043A (ja) | 2005-01-19 | 2008-07-24 | ブリストル−マイヤーズ スクイブ カンパニー | 血栓塞栓障害治療用のｐ２ｙ１受容体阻害剤としての２−フェノキシ−ｎ−（１，３，４−チアジアゾール−２−イル）ピリジン−３−アミン誘導体および関連化合物 |
| KR20150029766A (ko) | 2005-02-25 | 2015-03-18 | 에사넥스, 인코포레이티드 | 테트라히드로인돌론 및 테트라히드로인다졸론 유도체 |
| EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| US7714002B2 (en) | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| ATE502924T1 (de) | 2005-06-27 | 2011-04-15 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
-
2006
- 2006-06-26 US US11/474,888 patent/US7728008B2/en active Active
- 2006-06-26 KR KR1020087002124A patent/KR20080027890A/ko not_active Application Discontinuation
- 2006-06-26 WO PCT/US2006/024914 patent/WO2007002637A1/en active Application Filing
- 2006-06-26 AT AT06774067T patent/ATE505468T1/de not_active IP Right Cessation
- 2006-06-26 JP JP2008519471A patent/JP2008543972A/ja active Pending
- 2006-06-26 MX MX2007016501A patent/MX2007016501A/es not_active Application Discontinuation
- 2006-06-26 EP EP06774067A patent/EP1896466B1/en active Active
- 2006-06-26 TW TW095122981A patent/TW200726764A/zh unknown
- 2006-06-26 AR ARP060102745A patent/AR056867A1/es unknown
- 2006-06-26 AU AU2006261828A patent/AU2006261828A1/en not_active Abandoned
- 2006-06-26 DE DE602006021306T patent/DE602006021306D1/de active Active
- 2006-06-27 PE PE2006000739A patent/PE20070016A1/es not_active Application Discontinuation
-
2007
- 2007-12-14 NO NO20076424A patent/NO20076424L/no not_active Application Discontinuation
-
2010
- 2010-04-16 US US12/761,447 patent/US8329718B2/en active Active
