JP2008542390A5 - - Google Patents
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- Publication number
- JP2008542390A5 JP2008542390A5 JP2008514865A JP2008514865A JP2008542390A5 JP 2008542390 A5 JP2008542390 A5 JP 2008542390A5 JP 2008514865 A JP2008514865 A JP 2008514865A JP 2008514865 A JP2008514865 A JP 2008514865A JP 2008542390 A5 JP2008542390 A5 JP 2008542390A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pharmaceutically acceptable
- acceptable salt
- formula
- imatinib
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims description 4
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims 4
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 229960002411 imatinib Drugs 0.000 claims 2
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68775805P | 2005-06-03 | 2005-06-03 | |
| US60/687,758 | 2005-06-03 | ||
| PCT/US2006/021307 WO2006132930A1 (en) | 2005-06-03 | 2006-06-02 | Combination of pyrimidylaminobenzamide compounds and imatinib for treating or preventing proliferative diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012203258A Division JP2013035853A (ja) | 2005-06-03 | 2012-09-14 | 増殖性疾患の処置または予防のためのピリミジルアミノベンズアミド化合物とイマチニブの組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542390A JP2008542390A (ja) | 2008-11-27 |
| JP2008542390A5 true JP2008542390A5 (enExample) | 2009-07-16 |
| JP5281887B2 JP5281887B2 (ja) | 2013-09-04 |
Family
ID=36968749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008514865A Expired - Fee Related JP5281887B2 (ja) | 2005-06-03 | 2006-06-02 | 増殖性疾患の処置または予防のためのピリミジルアミノベンズアミド化合物とイマチニブの組み合わせ |
| JP2012203258A Pending JP2013035853A (ja) | 2005-06-03 | 2012-09-14 | 増殖性疾患の処置または予防のためのピリミジルアミノベンズアミド化合物とイマチニブの組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012203258A Pending JP2013035853A (ja) | 2005-06-03 | 2012-09-14 | 増殖性疾患の処置または予防のためのピリミジルアミノベンズアミド化合物とイマチニブの組み合わせ |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7767688B2 (enExample) |
| EP (1) | EP1893213B1 (enExample) |
| JP (2) | JP5281887B2 (enExample) |
| KR (1) | KR101276425B1 (enExample) |
| CN (1) | CN101180060B (enExample) |
| AT (1) | ATE457727T1 (enExample) |
| AU (1) | AU2006255559B2 (enExample) |
| BR (1) | BRPI0611506A2 (enExample) |
| CA (1) | CA2608814C (enExample) |
| CY (1) | CY1110027T1 (enExample) |
| DE (1) | DE602006012313D1 (enExample) |
| DK (1) | DK1893213T3 (enExample) |
| ES (1) | ES2339593T3 (enExample) |
| HR (1) | HRP20100265T1 (enExample) |
| IL (1) | IL187408A0 (enExample) |
| MA (1) | MA29565B1 (enExample) |
| MX (1) | MX2007015159A (enExample) |
| NO (1) | NO20080037L (enExample) |
| NZ (1) | NZ563446A (enExample) |
| PL (1) | PL1893213T3 (enExample) |
| PT (1) | PT1893213E (enExample) |
| RU (1) | RU2430727C2 (enExample) |
| SI (1) | SI1893213T1 (enExample) |
| TN (1) | TNSN07453A1 (enExample) |
| WO (1) | WO2006132930A1 (enExample) |
| ZA (1) | ZA200709473B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE457727T1 (de) * | 2005-06-03 | 2010-03-15 | Novartis Ag | Kombination aus pyrimidylaminobenzamid- verbindungen und imatinib zur behandlung oder verhinderung proliferativer erkrankungen |
| TW201102068A (en) * | 2009-06-02 | 2011-01-16 | Novartis Ag | Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms |
| EP2382976A1 (en) | 2010-04-30 | 2011-11-02 | Hiroshima University | Use of pdgf-r inhibitors for the treatment of lymph node metastasis of gastric cancer |
| CN102719530B (zh) * | 2012-05-07 | 2013-11-06 | 厦门艾德生物医药科技有限公司 | 一种用于检测PDGFRα基因突变的引物、探针及试剂盒 |
| KR101386697B1 (ko) * | 2012-06-18 | 2014-04-18 | 아주대학교산학협력단 | 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물 |
| US20200206223A1 (en) | 2017-07-26 | 2020-07-02 | Ftf Pharma Private Limited | Liquid dosage forms of imatinib |
| CN116808044A (zh) | 2018-06-15 | 2023-09-29 | 汉达癌症医药责任有限公司 | 激酶抑制剂的盐类及其组合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| AR042042A1 (es) * | 2002-11-15 | 2005-06-08 | Sugen Inc | Administracion combinada de una indolinona con un agente quimioterapeutico para trastornos de proliferacion celular |
| ATE457727T1 (de) * | 2005-06-03 | 2010-03-15 | Novartis Ag | Kombination aus pyrimidylaminobenzamid- verbindungen und imatinib zur behandlung oder verhinderung proliferativer erkrankungen |
-
2006
- 2006-06-02 AT AT06760628T patent/ATE457727T1/de active
- 2006-06-02 BR BRPI0611506-3A patent/BRPI0611506A2/pt not_active IP Right Cessation
- 2006-06-02 RU RU2007147957/15A patent/RU2430727C2/ru not_active IP Right Cessation
- 2006-06-02 SI SI200630626T patent/SI1893213T1/sl unknown
- 2006-06-02 EP EP06760628A patent/EP1893213B1/en active Active
- 2006-06-02 NZ NZ563446A patent/NZ563446A/en not_active IP Right Cessation
- 2006-06-02 MX MX2007015159A patent/MX2007015159A/es active IP Right Grant
- 2006-06-02 HR HR20100265T patent/HRP20100265T1/hr unknown
- 2006-06-02 DK DK06760628.5T patent/DK1893213T3/da active
- 2006-06-02 JP JP2008514865A patent/JP5281887B2/ja not_active Expired - Fee Related
- 2006-06-02 KR KR1020077028059A patent/KR101276425B1/ko not_active Expired - Fee Related
- 2006-06-02 WO PCT/US2006/021307 patent/WO2006132930A1/en not_active Ceased
- 2006-06-02 ES ES06760628T patent/ES2339593T3/es active Active
- 2006-06-02 CN CN2006800181195A patent/CN101180060B/zh not_active Expired - Fee Related
- 2006-06-02 PT PT06760628T patent/PT1893213E/pt unknown
- 2006-06-02 DE DE602006012313T patent/DE602006012313D1/de active Active
- 2006-06-02 AU AU2006255559A patent/AU2006255559B2/en not_active Ceased
- 2006-06-02 US US11/915,650 patent/US7767688B2/en not_active Expired - Fee Related
- 2006-06-02 PL PL06760628T patent/PL1893213T3/pl unknown
- 2006-06-02 CA CA2608814A patent/CA2608814C/en not_active Expired - Fee Related
-
2007
- 2007-11-02 ZA ZA200709473A patent/ZA200709473B/xx unknown
- 2007-11-15 IL IL187408A patent/IL187408A0/en not_active IP Right Cessation
- 2007-11-30 TN TNP2007000453A patent/TNSN07453A1/en unknown
- 2007-12-26 MA MA30509A patent/MA29565B1/fr unknown
-
2008
- 2008-01-03 NO NO20080037A patent/NO20080037L/no not_active Application Discontinuation
-
2010
- 2010-04-02 US US12/753,184 patent/US8653093B2/en not_active Expired - Fee Related
- 2010-05-13 CY CY20101100416T patent/CY1110027T1/el unknown
-
2012
- 2012-09-14 JP JP2012203258A patent/JP2013035853A/ja active Pending
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