JP2016020375A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016020375A5 JP2016020375A5 JP2015189993A JP2015189993A JP2016020375A5 JP 2016020375 A5 JP2016020375 A5 JP 2016020375A5 JP 2015189993 A JP2015189993 A JP 2015189993A JP 2015189993 A JP2015189993 A JP 2015189993A JP 2016020375 A5 JP2016020375 A5 JP 2016020375A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- benzamide
- phenyl
- excluding
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 208000010412 Glaucoma Diseases 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- -1 4-methylpiperazin-1-ylmethyl Chemical group 0.000 claims 5
- 206010019233 Headaches Diseases 0.000 claims 5
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 231100000869 headache Toxicity 0.000 claims 5
- 201000006792 Lennox-Gastaut syndrome Diseases 0.000 claims 4
- 208000019695 Migraine disease Diseases 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 4
- 108010029485 Protein Isoforms Proteins 0.000 claims 4
- 208000008445 altitude sickness Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 206010015037 epilepsy Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 206010027599 migraine Diseases 0.000 claims 4
- 201000003142 neovascular glaucoma Diseases 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 3
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 102000003846 Carbonic anhydrases Human genes 0.000 claims 1
- 108090000209 Carbonic anhydrases Proteins 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 claims 1
- XLSZMDLNRCVEIJ-UHFFFAOYSA-N methylimidazole Natural products CC1=CNC=N1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09161720 | 2009-06-02 | ||
| EP09161720.9 | 2009-06-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513590A Division JP2012528824A (ja) | 2009-06-02 | 2010-06-01 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017146753A Division JP2017203037A (ja) | 2009-06-02 | 2017-07-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016020375A JP2016020375A (ja) | 2016-02-04 |
| JP2016020375A5 true JP2016020375A5 (enExample) | 2016-06-02 |
Family
ID=40902237
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513590A Withdrawn JP2012528824A (ja) | 2009-06-02 | 2010-06-01 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
| JP2015189993A Ceased JP2016020375A (ja) | 2009-06-02 | 2015-09-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
| JP2017146753A Withdrawn JP2017203037A (ja) | 2009-06-02 | 2017-07-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513590A Withdrawn JP2012528824A (ja) | 2009-06-02 | 2010-06-01 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017146753A Withdrawn JP2017203037A (ja) | 2009-06-02 | 2017-07-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9623025B2 (enExample) |
| EP (1) | EP2437745B1 (enExample) |
| JP (3) | JP2012528824A (enExample) |
| TW (2) | TW201102068A (enExample) |
| WO (2) | WO2010139678A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101386697B1 (ko) | 2012-06-18 | 2014-04-18 | 아주대학교산학협력단 | 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물 |
| KR101778004B1 (ko) * | 2015-06-22 | 2017-09-15 | (주) 에빅스젠 | 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물 |
| WO2018211474A1 (en) | 2017-05-19 | 2018-11-22 | Trudell Medical International | Positive expiratory pressure device |
| USD903097S1 (en) | 2018-05-18 | 2020-11-24 | Trudell Medical International | Mask |
| USD874064S1 (en) | 2018-05-18 | 2020-01-28 | Trudell Medical International | Mask |
| TWI770624B (zh) | 2018-06-15 | 2022-07-11 | 漢達生技醫藥股份有限公司 | 尼洛替尼十二烷基硫酸鹽在製備用於治療慢性骨髓性白血病之劑型的用途 |
| USD893806S1 (en) | 2018-11-09 | 2020-08-18 | Trudell Medical Internationl | Mask and shroud |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (enExample) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5798380A (en) * | 1996-02-21 | 1998-08-25 | Wisconsin Alumni Research Foundation | Cytoskeletal active agents for glaucoma therapy |
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| PT1478380E (pt) * | 2002-02-27 | 2006-12-29 | Ab Science | Utilização de inibidores de tirosina-cinases para tratar doenças do snc |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| US8512738B2 (en) * | 2004-04-30 | 2013-08-20 | Allergan, Inc. | Biodegradable intravitreal tyrosine kinase implants |
| JP5281887B2 (ja) * | 2005-06-03 | 2013-09-04 | ノバルティス アーゲー | 増殖性疾患の処置または予防のためのピリミジルアミノベンズアミド化合物とイマチニブの組み合わせ |
| GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| AU2008242444B2 (en) * | 2007-04-17 | 2013-05-02 | Imclone Llc | PDGFRBeta-specific inhibitors |
| PE20090368A1 (es) * | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
| JP6623812B2 (ja) * | 2016-02-17 | 2019-12-25 | セイコーエプソン株式会社 | 位置検出装置、及び、そのコントラスト調整方法 |
-
2010
- 2010-05-31 TW TW099117452A patent/TW201102068A/zh unknown
- 2010-06-01 TW TW099117619A patent/TWI565466B/zh not_active IP Right Cessation
- 2010-06-01 WO PCT/EP2010/057598 patent/WO2010139678A1/en not_active Ceased
- 2010-06-01 US US13/375,946 patent/US9623025B2/en not_active Expired - Fee Related
- 2010-06-01 EP EP10722356.2A patent/EP2437745B1/en not_active Not-in-force
- 2010-06-01 JP JP2012513590A patent/JP2012528824A/ja not_active Withdrawn
- 2010-06-01 WO PCT/US2010/036836 patent/WO2010141427A1/en not_active Ceased
-
2015
- 2015-09-28 JP JP2015189993A patent/JP2016020375A/ja not_active Ceased
-
2017
- 2017-07-28 JP JP2017146753A patent/JP2017203037A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016020375A5 (enExample) | ||
| JP2012528824A5 (enExample) | ||
| RU2458920C2 (ru) | Новые соединения | |
| JP2013543896A5 (enExample) | ||
| PH12019501707A1 (en) | N-[4-fluoro-5-[[(2s,4s)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]-1-piperidyl]methyl]thiazol-2-yl]acetamide as oga inhibitor | |
| JP2016505637A5 (enExample) | ||
| JP2018537507A5 (enExample) | ||
| RU2017116196A (ru) | 2-амино-6-(дифторметил)-5,5-дифтор-6-фенил-3,4,5,6-тетрагидропиридины как ингибиторы васе1 | |
| JP2017504611A5 (enExample) | ||
| PE20180227A1 (es) | Benzamidas sustituidas con 1,3-tiazol-2-ilo | |
| PE20170705A1 (es) | Nuevos compuestos como inhibidores de ret (reorganizado durante la transfeccion) | |
| JP2007519649A5 (enExample) | ||
| EA201691242A1 (ru) | Фармацевтические композиции, содержащие azd9291 | |
| RU2017120217A (ru) | 2-амино-5,5-дифтор-6-(фторметил)-6-фенил-3,4,5,6-тетрагидпропиридины в качестве ингибиторов bace1 | |
| CY1124523T1 (el) | Ν-[5-(αμινοσουλφονυλο)-4-μεθυλ-1,3-θειαζολ-2-υλ]-ν-μεθυλ-2-[4-(2-πυριδινυλ)-φαινυλ]-ημιενυδρη ελευθερη βαση ακεταμιδιου, μεθοδοι κατασκευης και χρησεις αυτης | |
| BR112017004673A2 (pt) | formas cristalinas de 2-(4-(4-etoxi-6-oxo-1,6-diidropiridin-3-ila)-2-fluorofenil)-n-(5-(1,1,1-trifluoro-2-metilpropan-2-il)isoxazol-3-il) acetamida | |
| IL282006A (en) | Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide | |
| MX2021010133A (es) | Forma cristalina de 1-(1-oxo-1,2-dihidroisoquinolin-5-il)-5-(trifl uorometil)-n-(2-(trifluorometil)piridin-4-il)-1h-pirazol-4-carbox amida monohidratada. | |
| JP2016027060A5 (enExample) | ||
| JP2009532438A5 (enExample) | ||
| EA201990664A1 (ru) | Производные 5-[2-(пиридин-2-иламино)-1,3-тиазол-5-ил]-2,3-дигидро-1h-изоиндол-1-она и их применение в качестве двойных ингибиторов фосфатидилинозитол-3-киназ дельта и гамма | |
| HRP20241716T1 (hr) | Postupci liječenja promjena u ponašanju | |
| JP2020529995A5 (enExample) | ||
| RU2014144951A (ru) | Новое 1-замещенное производное индазола | |
| JP2017509611A5 (enExample) |