TW201102068A - Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms - Google Patents

Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms Download PDF

Info

Publication number
TW201102068A
TW201102068A TW099117452A TW99117452A TW201102068A TW 201102068 A TW201102068 A TW 201102068A TW 099117452 A TW099117452 A TW 099117452A TW 99117452 A TW99117452 A TW 99117452A TW 201102068 A TW201102068 A TW 201102068A
Authority
TW
Taiwan
Prior art keywords
methyl
pharmaceutically acceptable
phenyl
acceptable salt
treatment
Prior art date
Application number
TW099117452A
Other languages
English (en)
Chinese (zh)
Inventor
Seppo Parkkila
Claudiu Supuran
Thaddeus Dryja
Mitchell Brigell
Original Assignee
Novartis Ag
Univ Tampere
Claudiu Supuran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Tampere, Claudiu Supuran filed Critical Novartis Ag
Publication of TW201102068A publication Critical patent/TW201102068A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW099117452A 2009-06-02 2010-05-31 Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms TW201102068A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09161720 2009-06-02
US18532809P 2009-06-09 2009-06-09

Publications (1)

Publication Number Publication Date
TW201102068A true TW201102068A (en) 2011-01-16

Family

ID=40902237

Family Applications (2)

Application Number Title Priority Date Filing Date
TW099117452A TW201102068A (en) 2009-06-02 2010-05-31 Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms
TW099117619A TWI565466B (zh) 2009-06-02 2010-06-01 由α-碳酸酐酶之異形體調節之哺乳動物之疾病之治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW099117619A TWI565466B (zh) 2009-06-02 2010-06-01 由α-碳酸酐酶之異形體調節之哺乳動物之疾病之治療

Country Status (5)

Country Link
US (1) US9623025B2 (enExample)
EP (1) EP2437745B1 (enExample)
JP (3) JP2012528824A (enExample)
TW (2) TW201102068A (enExample)
WO (2) WO2010139678A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107735091A (zh) * 2015-06-22 2018-02-23 爱维斯健有限公司 包含伊马替尼作为活性成分的用于预防和治疗干眼病的药物组合物

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101386697B1 (ko) * 2012-06-18 2014-04-18 아주대학교산학협력단 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물
WO2018211474A1 (en) 2017-05-19 2018-11-22 Trudell Medical International Positive expiratory pressure device
USD874064S1 (en) 2018-05-18 2020-01-28 Trudell Medical International Mask
USD903097S1 (en) 2018-05-18 2020-11-24 Trudell Medical International Mask
TWI787523B (zh) 2018-06-15 2022-12-21 漢達生技醫藥股份有限公司 達沙替尼十二烷基硫酸鹽之結晶
USD893806S1 (en) 2018-11-09 2020-08-18 Trudell Medical Internationl Mask and shroud

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (enExample) 1992-04-03 1994-06-21 Ciba Geigy Ag
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US5798380A (en) * 1996-02-21 1998-08-25 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
PT1478380E (pt) * 2002-02-27 2006-12-29 Ab Science Utilização de inibidores de tirosina-cinases para tratar doenças do snc
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
BRPI0510485A (pt) * 2004-04-30 2007-11-13 Allergan Inc implantes inibidores de tirosina cinase intravìtreos biodegradáveis
DK1893213T3 (da) * 2005-06-03 2010-06-07 Novartis Ag Kombination af pyrimidylaminobenzamidforbindelser og imatinib til behandling eller forebyggelse af proliferative sygdomme
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
EA019595B1 (ru) * 2007-04-17 2014-04-30 Имклоун Элэлси СПЕЦИФИЧНЫЕ ИНГИБИТОРЫ PDGFRβ
PE20090368A1 (es) * 2007-06-19 2009-04-28 Boehringer Ingelheim Int Anticuerpos anti-igf
JP6623812B2 (ja) * 2016-02-17 2019-12-25 セイコーエプソン株式会社 位置検出装置、及び、そのコントラスト調整方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107735091A (zh) * 2015-06-22 2018-02-23 爱维斯健有限公司 包含伊马替尼作为活性成分的用于预防和治疗干眼病的药物组合物

Also Published As

Publication number Publication date
WO2010141427A1 (en) 2010-12-09
EP2437745A1 (en) 2012-04-11
JP2012528824A (ja) 2012-11-15
EP2437745B1 (en) 2017-08-23
TWI565466B (zh) 2017-01-11
US9623025B2 (en) 2017-04-18
US20120088776A1 (en) 2012-04-12
TW201102069A (en) 2011-01-16
WO2010139678A1 (en) 2010-12-09
JP2017203037A (ja) 2017-11-16
JP2016020375A (ja) 2016-02-04

Similar Documents

Publication Publication Date Title
TWI908405B (zh) 新穎甲基喹唑啉酮衍生物
TWI246917B (en) Combinations of a receptor tyrosine kinase inhibitor with an organic compound capable of binding to alpha1-acidic glycoprotein
CN104519887B (zh) 包含B‑Raf抑制剂、EGFR抑制剂和任选PI3Kα抑制剂的药物组合
JP2022537772A (ja) 新規egfr阻害剤
JP5778735B2 (ja) Egfr依存性疾患またはegfrファミリーメンバーを標的とする薬剤に対して耐性を獲得した疾患を治療するためのピリミジン誘導体の使用
TW201010999A (en) Treatment of pulmonary arterial hypertension
TW200522966A (en) Dosing schedule for a novel anticancer agent
RU2630975C2 (ru) Режим дозирования pi-3 киназы
JP2018515544A (ja) Egfr変異癌を治療する方法
TW202502325A (zh) 治療黑色素瘤的藥物組合的用途
JP6795518B2 (ja) キナーゼを阻害する組成物及び方法
US20120258080A1 (en) Pyridopyrazine derivatives and their use
JP2017203037A (ja) アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置
TW202313050A (zh) 組合療法
US20160303137A1 (en) Dual pi3k and wnt pathway inhibition as a treatment for cancer
JP2023502252A (ja) 虚血再灌流傷害および/または肺傷害を処置するための化合物、組成物および方法
US20230355618A1 (en) Raf inhibitor for treating low grade glioma
TW200822926A (en) Method of optimizing the treatment of philadelphia-positive leukemia with Abl tyrosine kinase inhibitors
CN113543784A (zh) 用于治疗或预防癌症的喹啉衍生物
EP2177222B1 (en) Pyrimidylaminobenzamide derivatives for the treatment of neurofibromatosis
US20260069578A1 (en) Treatment of neutrophilic dermatoses
KR101579993B1 (ko) 이마티닙을 이용한 티로신 키나제 수용체 kit에 의해 매개되는 증식성 질환의 치료를 최적화하는 방법
HK40118235A (en) Quinoline derivatives for use in the treatment or prevention of cancer
US20130203817A1 (en) Novel Inhibitors of LYN Kinase
CN117615762A (zh) 组合疗法