ATE457727T1 - Kombination aus pyrimidylaminobenzamid- verbindungen und imatinib zur behandlung oder verhinderung proliferativer erkrankungen - Google Patents

Kombination aus pyrimidylaminobenzamid- verbindungen und imatinib zur behandlung oder verhinderung proliferativer erkrankungen

Info

Publication number
ATE457727T1
ATE457727T1 AT06760628T AT06760628T ATE457727T1 AT E457727 T1 ATE457727 T1 AT E457727T1 AT 06760628 T AT06760628 T AT 06760628T AT 06760628 T AT06760628 T AT 06760628T AT E457727 T1 ATE457727 T1 AT E457727T1
Authority
AT
Austria
Prior art keywords
combination
imatinib
pyrimidylaminobensamide
prevention
compounds
Prior art date
Application number
AT06760628T
Other languages
English (en)
Inventor
Leila Alland
Paul Manley
Juergen Mestan
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE457727T1 publication Critical patent/ATE457727T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06760628T 2005-06-03 2006-06-02 Kombination aus pyrimidylaminobenzamid- verbindungen und imatinib zur behandlung oder verhinderung proliferativer erkrankungen ATE457727T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68775805P 2005-06-03 2005-06-03
PCT/US2006/021307 WO2006132930A1 (en) 2005-06-03 2006-06-02 Combination of pyrimidylaminobenzamide compounds and imatinib for treating or preventing proliferative diseases

Publications (1)

Publication Number Publication Date
ATE457727T1 true ATE457727T1 (de) 2010-03-15

Family

ID=36968749

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06760628T ATE457727T1 (de) 2005-06-03 2006-06-02 Kombination aus pyrimidylaminobenzamid- verbindungen und imatinib zur behandlung oder verhinderung proliferativer erkrankungen

Country Status (27)

Country Link
US (2) US7767688B2 (de)
EP (1) EP1893213B1 (de)
JP (2) JP5281887B2 (de)
KR (1) KR101276425B1 (de)
CN (1) CN101180060B (de)
AT (1) ATE457727T1 (de)
AU (1) AU2006255559B2 (de)
BR (1) BRPI0611506A2 (de)
CA (1) CA2608814C (de)
CY (1) CY1110027T1 (de)
DE (1) DE602006012313D1 (de)
DK (1) DK1893213T3 (de)
ES (1) ES2339593T3 (de)
HK (1) HK1115528A1 (de)
HR (1) HRP20100265T1 (de)
IL (1) IL187408A0 (de)
MA (1) MA29565B1 (de)
MX (1) MX2007015159A (de)
NO (1) NO20080037L (de)
NZ (1) NZ563446A (de)
PL (1) PL1893213T3 (de)
PT (1) PT1893213E (de)
RU (1) RU2430727C2 (de)
SI (1) SI1893213T1 (de)
TN (1) TNSN07453A1 (de)
WO (1) WO2006132930A1 (de)
ZA (1) ZA200709473B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1893213E (pt) * 2005-06-03 2010-04-19 Novartis Ag Combinação de compostos pirimidilaminobenzamida e imatinib para tratamento ou prevenção de doenças proliferativas
TW201102068A (en) * 2009-06-02 2011-01-16 Novartis Ag Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms
EP2382976A1 (de) * 2010-04-30 2011-11-02 Hiroshima University Verwendung von PDGF-R-Inhibitoren zur Behandlung der Lymphknotenmetastasen von Magenkrebs
CN102719530B (zh) * 2012-05-07 2013-11-06 厦门艾德生物医药科技有限公司 一种用于检测PDGFRα基因突变的引物、探针及试剂盒
KR101386697B1 (ko) 2012-06-18 2014-04-18 아주대학교산학협력단 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물
RU2020108342A (ru) 2017-07-26 2021-08-26 Эф Тэ Эф Фарма Привейт Лимитед Жидкие дозируемые лекарственные формы иматиниба
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
PT1893213E (pt) * 2005-06-03 2010-04-19 Novartis Ag Combinação de compostos pirimidilaminobenzamida e imatinib para tratamento ou prevenção de doenças proliferativas

Also Published As

Publication number Publication date
JP2008542390A (ja) 2008-11-27
CA2608814A1 (en) 2006-12-14
AU2006255559A1 (en) 2006-12-14
HK1115528A1 (en) 2008-12-05
RU2007147957A (ru) 2009-07-20
RU2430727C2 (ru) 2011-10-10
NO20080037L (no) 2008-01-03
EP1893213B1 (de) 2010-02-17
US20080312252A1 (en) 2008-12-18
CN101180060A (zh) 2008-05-14
MX2007015159A (es) 2008-02-15
EP1893213A1 (de) 2008-03-05
JP5281887B2 (ja) 2013-09-04
SI1893213T1 (sl) 2010-05-31
KR20080021633A (ko) 2008-03-07
IL187408A0 (en) 2011-07-31
DE602006012313D1 (de) 2010-04-01
KR101276425B1 (ko) 2013-06-19
ES2339593T3 (es) 2010-05-21
US20100190800A1 (en) 2010-07-29
PL1893213T3 (pl) 2010-08-31
DK1893213T3 (da) 2010-06-07
ZA200709473B (en) 2008-12-31
MA29565B1 (fr) 2008-06-02
US7767688B2 (en) 2010-08-03
US8653093B2 (en) 2014-02-18
JP2013035853A (ja) 2013-02-21
CA2608814C (en) 2013-09-03
HRP20100265T1 (hr) 2010-06-30
NZ563446A (en) 2011-02-25
CN101180060B (zh) 2011-12-28
PT1893213E (pt) 2010-04-19
CY1110027T1 (el) 2015-01-14
TNSN07453A1 (en) 2009-03-17
WO2006132930A1 (en) 2006-12-14
BRPI0611506A2 (pt) 2010-09-14
AU2006255559B2 (en) 2009-12-17

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