JP2008542238A5 - - Google Patents
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- Publication number
- JP2008542238A5 JP2008542238A5 JP2008512832A JP2008512832A JP2008542238A5 JP 2008542238 A5 JP2008542238 A5 JP 2008542238A5 JP 2008512832 A JP2008512832 A JP 2008512832A JP 2008512832 A JP2008512832 A JP 2008512832A JP 2008542238 A5 JP2008542238 A5 JP 2008542238A5
- Authority
- JP
- Japan
- Prior art keywords
- indole
- chloro
- acetic acid
- trioxospiro
- pyrrolidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC=C*=C(C1(*N(*)**1)*N1*)C1=** Chemical compound CC=C*=C(C1(*N(*)**1)*N1*)C1=** 0.000 description 3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05104428.7 | 2005-05-24 | ||
| EP05104428 | 2005-05-24 | ||
| US68863105P | 2005-06-08 | 2005-06-08 | |
| US60/688,631 | 2005-06-08 | ||
| PCT/EP2006/062545 WO2006125784A1 (en) | 2005-05-24 | 2006-05-23 | Tricyclic spiro derivatives as crth2 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542238A JP2008542238A (ja) | 2008-11-27 |
| JP2008542238A5 true JP2008542238A5 (https=) | 2009-07-09 |
| JP5567268B2 JP5567268B2 (ja) | 2014-08-06 |
Family
ID=35478408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512832A Expired - Fee Related JP5567268B2 (ja) | 2005-05-24 | 2006-05-23 | Ｃｒｔｈ２の調節剤としての三環系スピロ誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8236963B2 (https=) |
| EP (1) | EP1891075B1 (https=) |
| JP (1) | JP5567268B2 (https=) |
| KR (1) | KR101333861B1 (https=) |
| CN (1) | CN101300259B (https=) |
| AR (1) | AR055959A1 (https=) |
| AT (1) | ATE529429T1 (https=) |
| AU (1) | AU2006251138C1 (https=) |
| BR (1) | BRPI0610209A2 (https=) |
| CA (1) | CA2602965C (https=) |
| DK (1) | DK1891075T3 (https=) |
| ES (1) | ES2375614T3 (https=) |
| MX (1) | MX2007014256A (https=) |
| NZ (1) | NZ562772A (https=) |
| PL (1) | PL1891075T3 (https=) |
| PT (1) | PT1891075E (https=) |
| RU (1) | RU2478639C2 (https=) |
| UA (1) | UA90145C2 (https=) |
| WO (1) | WO2006125784A1 (https=) |
| ZA (1) | ZA200709819B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0715179A2 (pt) | 2006-08-07 | 2013-06-11 | Actelion Pharmaceuticals Ltd | composto, composiÇço farmacÊutica e uso de um composto |
| US20120115895A1 (en) | 2009-07-15 | 2012-05-10 | Merck Serono S.A. | Tricyclic indole-derived spiro derivatives as crth2 modulators |
| KR20120099462A (ko) | 2009-11-12 | 2012-09-10 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | 스피로-옥신돌 ｍｄｍ2 길항제 |
| PT2558447E (pt) | 2010-03-22 | 2014-11-25 | Actelion Pharmaceuticals Ltd | Derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9hcarbazol e o seu uso como moduladores do receptor de prostaglandina d2 |
| AU2011326395B2 (en) | 2010-11-12 | 2016-01-07 | Ascenta Licensing Corporation | Spiro-oxindole MDM2 antagonists |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| DK2697223T3 (en) | 2011-04-14 | 2016-09-05 | Actelion Pharmaceuticals Ltd | 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor |
| US8629141B2 (en) | 2011-05-11 | 2014-01-14 | The Regents Of The University Of Michigan | Spiro-oxindole MDM2 antagonists |
| EP2790696A1 (en) | 2011-12-16 | 2014-10-22 | Atopix Therapeutics Limited | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| CN103554118B (zh) * | 2013-10-15 | 2015-08-19 | 华东师范大学 | 四氢呋喃并苯并二氢吡喃多环化合物及其应用 |
| CN103554119B (zh) * | 2013-10-15 | 2015-09-16 | 华东师范大学 | 四氢呋喃并苯并二氢吡喃多环化合物的制备方法 |
| CN103554120B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物的制备方法 |
| CN103554121B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物及其应用 |
| AR099767A1 (es) | 2014-03-17 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados del ácido acético azaindol y su uso como moduladores del receptor de prostaglandina d2 |
| KR20160133536A (ko) | 2014-03-18 | 2016-11-22 | 액테리온 파마슈티칼 리미티드 | 아자인돌 아세트산 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 이의 용도 |
| US9745253B2 (en) | 2015-03-13 | 2017-08-29 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as HDAC8 inhibitors |
| ES2733468T3 (es) | 2015-07-15 | 2019-11-29 | Hoffmann La Roche | Derivados de etinilo como moduladores de los receptores metabotrópicos de glutamato |
| AU2016323262B2 (en) | 2015-09-15 | 2020-11-19 | Idorsia Pharmaceuticals Ltd | Crystalline forms |
| RU2631856C1 (ru) * | 2016-05-04 | 2017-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Чувашский государственный университет имени И.Н. Ульянова" | Способ получения аммонийных солей 3-амино-8-гидрокси-1,6-диоксо-4-циано-2,7-диазаспиро[4.4]нон-3-ен-2-идов |
| WO2018015235A1 (en) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| CN109384787B (zh) * | 2017-08-08 | 2021-04-16 | 沈阳药科大学 | 一种一价银催化的氢化吡啶螺二氢吲哚环的合成方法 |
| CN109384794B (zh) * | 2017-08-08 | 2020-06-19 | 沈阳药科大学 | 质子酸催化的一类四环吲哚骨架的合成方法 |
| CN109369658B (zh) * | 2017-08-08 | 2020-01-31 | 沈阳药科大学 | 一种螺[吡咯烷-3,3`-氧化吲哚]环系的合成方法 |
| KR101857408B1 (ko) | 2018-02-28 | 2018-05-14 | 경북대학교 산학협력단 | 탈모 예방 또는 치료용 조성물 |
| EP3902805A4 (en) | 2018-12-28 | 2023-03-01 | SPV Therapeutics Inc. | CYCLINE-DEPENDENT KINASE INHIBITORS |
| CN112876488B (zh) * | 2021-02-18 | 2021-12-21 | 苏州大学 | 螺环吲哚啉衍生物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52879B1 (en) * | 1981-05-12 | 1988-03-30 | Ici Plc | Pharmaceutical spiro-hydantoin derivatives |
| IE53102B1 (en) | 1981-05-12 | 1988-06-22 | Ici Plc | Pharmaceutical spiro-succinimide derivatives |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| NZ528846A (en) * | 1999-03-12 | 2005-05-27 | Boehringer Ingelheim Pharma | Compounds useful as anti-inflammatory agents |
| SE0200411D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200356D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| GB2388540A (en) | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
| AU2003277285B2 (en) | 2002-10-04 | 2007-12-13 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| EP1556356B1 (en) | 2002-10-21 | 2006-05-31 | Warner-Lambert Company LLC | Tetrahydroquinoline derivatives as crth2 antagonists |
| DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| SE0301650D0 (sv) | 2003-06-04 | 2003-06-04 | Astrazeneca Ab | Novel compounds |
| SE0301653D0 (sv) | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| US20050038070A1 (en) | 2003-07-09 | 2005-02-17 | Amgen Inc. | Asthma and allergic inflammation modulators |
| MXPA06011891A (es) | 2004-04-20 | 2007-04-24 | Pfizer | Metodo para tratar el dolor neuropatico. |
-
2006
- 2006-05-23 NZ NZ562772A patent/NZ562772A/en not_active IP Right Cessation
- 2006-05-23 AT AT06763238T patent/ATE529429T1/de active
- 2006-05-23 AU AU2006251138A patent/AU2006251138C1/en not_active Ceased
- 2006-05-23 DK DK06763238.0T patent/DK1891075T3/da active
- 2006-05-23 EP EP06763238A patent/EP1891075B1/en active Active
- 2006-05-23 CN CN2006800266403A patent/CN101300259B/zh not_active Expired - Fee Related
- 2006-05-23 US US11/919,471 patent/US8236963B2/en not_active Expired - Fee Related
- 2006-05-23 ES ES06763238T patent/ES2375614T3/es active Active
- 2006-05-23 RU RU2007147430/04A patent/RU2478639C2/ru not_active IP Right Cessation
- 2006-05-23 PL PL06763238T patent/PL1891075T3/pl unknown
- 2006-05-23 ZA ZA200709819A patent/ZA200709819B/xx unknown
- 2006-05-23 CA CA2602965A patent/CA2602965C/en not_active Expired - Fee Related
- 2006-05-23 WO PCT/EP2006/062545 patent/WO2006125784A1/en not_active Ceased
- 2006-05-23 BR BRPI0610209-3A patent/BRPI0610209A2/pt not_active IP Right Cessation
- 2006-05-23 PT PT06763238T patent/PT1891075E/pt unknown
- 2006-05-23 MX MX2007014256A patent/MX2007014256A/es active IP Right Grant
- 2006-05-23 UA UAA200713923A patent/UA90145C2/ru unknown
- 2006-05-23 KR KR1020077029797A patent/KR101333861B1/ko not_active Expired - Fee Related
- 2006-05-23 JP JP2008512832A patent/JP5567268B2/ja not_active Expired - Fee Related
- 2006-05-24 AR ARP060102148A patent/AR055959A1/es unknown
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