JP2008542214A5 - - Google Patents
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- Publication number
- JP2008542214A5 JP2008542214A5 JP2008512730A JP2008512730A JP2008542214A5 JP 2008542214 A5 JP2008542214 A5 JP 2008542214A5 JP 2008512730 A JP2008512730 A JP 2008512730A JP 2008512730 A JP2008512730 A JP 2008512730A JP 2008542214 A5 JP2008542214 A5 JP 2008542214A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- cancer
- combination according
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FNHKPVJBJVTLMP-UHFFFAOYSA-N CNC(c1nccc(Oc(cc2)cc(F)c2NC(Nc(cc2)cc(C(F)(F)F)c2Cl)=O)c1)=O Chemical compound CNC(c1nccc(Oc(cc2)cc(F)c2NC(Nc(cc2)cc(C(F)(F)F)c2Cl)=O)c1)=O FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05011477 | 2005-05-27 | ||
| PCT/EP2006/004524 WO2006125540A1 (en) | 2005-05-27 | 2006-05-13 | Combination therapy comprising a diaryl urea compound and a pi3, akt kinase or mtor inhibitors (rapamycins) for cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008542214A JP2008542214A (ja) | 2008-11-27 |
| JP2008542214A5 true JP2008542214A5 (https=) | 2009-05-07 |
Family
ID=36636325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512730A Pending JP2008542214A (ja) | 2005-05-27 | 2006-05-13 | 疾患を処置するためのジアリールウレア化合物およびｐｉ３、ａｋｔキナーゼまたはｍｔｏｒ阻害剤（ラパマイシン）を含む組合せ治療 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1888067A1 (https=) |
| JP (1) | JP2008542214A (https=) |
| KR (1) | KR20080018908A (https=) |
| CN (1) | CN101257903A (https=) |
| AU (1) | AU2006251429A1 (https=) |
| BR (1) | BRPI0610048A2 (https=) |
| CA (1) | CA2609389A1 (https=) |
| IL (1) | IL187508A0 (https=) |
| MX (1) | MX2007014726A (https=) |
| RU (1) | RU2007148266A (https=) |
| WO (1) | WO2006125540A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| EA010485B1 (ru) | 2003-07-23 | 2008-10-30 | Байер Фамэсьютиклс Копэрейшн | Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты) |
| SG160364A1 (en) | 2005-03-07 | 2010-04-29 | Bayer Schering Pharma Ag | Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer |
| CA2633400A1 (en) * | 2005-12-15 | 2007-06-21 | Bayer Healthcare Ag | Diaryl urea for treating virus infections |
| AR062927A1 (es) | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
| JP5885012B2 (ja) * | 2007-01-19 | 2016-03-15 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ | Ｋｉｔ阻害剤に対して獲得した抵抗性を有する癌の処置 |
| US20100173954A1 (en) * | 2007-01-19 | 2010-07-08 | Bayer Healthcare Llc | Treatment of cancers having resistance to chemotherapeutic agents |
| US7947723B2 (en) | 2008-02-01 | 2011-05-24 | Spelman College | Synthesis and anti-proliferative effect of benzimidazole derivatives |
| EP2278966B1 (en) * | 2008-03-21 | 2019-10-09 | The University of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| JP2011525503A (ja) * | 2008-06-25 | 2011-09-22 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 心不全を処置するためのジアリールウレア |
| WO2010038165A1 (en) * | 2008-09-30 | 2010-04-08 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
| WO2010138820A2 (en) * | 2009-05-28 | 2010-12-02 | President And Fellows Of Harvard College | N,n-diarylurea compounds and n,n'-diarylthiourea compounds as inhibitors of translation initiation |
| CN102775385A (zh) * | 2011-05-10 | 2012-11-14 | 湖南有色凯铂生物药业有限公司 | N-取代苯基-n’-取代杂环脲类化合物及其作为抗癌药物的应用 |
| CN102885814A (zh) * | 2012-01-17 | 2013-01-23 | 湖南有色凯铂生物药业有限公司 | 一种化合物及其作为抗癌药物的应用 |
| CN102643229A (zh) * | 2012-01-17 | 2012-08-22 | 湖南有色凯铂生物药业有限公司 | N-((4-氯-3-三氟甲基)苯基)-n’-((2-氟-4-(2-氨基甲酰基)-4-吡啶基氧)苯基)脲及其作为抗癌药物的应用 |
| CN102940884B (zh) * | 2012-11-19 | 2013-11-06 | 上海市肿瘤研究所 | 一种肝癌细胞的抑制剂及其在抑制肿瘤生长方面的应用 |
| US10420761B2 (en) | 2013-03-15 | 2019-09-24 | University Of Florida Research Foundation, Inc. | Allosteric inhibitors of thymidylate synthase |
| HRP20211446T1 (hr) * | 2014-12-17 | 2021-12-24 | Pfizer Inc. | Formulacije inhibitora pi3k/mtor za intravensko davanje |
| CN104892632B (zh) * | 2015-06-03 | 2017-12-26 | 道中道（菏泽）制药有限公司 | 一种晶体形式的依维莫司及其制备方法 |
| CN104906086A (zh) * | 2015-06-24 | 2015-09-16 | 安徽四正医药科技有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗肾小球肾炎药物的应用 |
| WO2016209688A1 (en) | 2015-06-24 | 2016-12-29 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of cancer and uses thereof |
| KR102544163B1 (ko) * | 2022-08-10 | 2023-06-16 | 주식회사 하이밸 | 소음저감형 유량 및 압력 조절용 감압밸브 |
| CN115804844B (zh) * | 2022-09-26 | 2024-05-10 | 郑州大学 | 靶向抑制pak4的抑制剂在制备肿瘤防治药剂中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA010485B1 (ru) * | 2003-07-23 | 2008-10-30 | Байер Фамэсьютиклс Копэрейшн | Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты) |
-
2006
- 2006-05-13 KR KR1020077030272A patent/KR20080018908A/ko not_active Withdrawn
- 2006-05-13 JP JP2008512730A patent/JP2008542214A/ja active Pending
- 2006-05-13 WO PCT/EP2006/004524 patent/WO2006125540A1/en not_active Ceased
- 2006-05-13 CN CNA2006800185177A patent/CN101257903A/zh active Pending
- 2006-05-13 AU AU2006251429A patent/AU2006251429A1/en not_active Abandoned
- 2006-05-13 RU RU2007148266/15A patent/RU2007148266A/ru not_active Application Discontinuation
- 2006-05-13 EP EP06724813A patent/EP1888067A1/en not_active Withdrawn
- 2006-05-13 BR BRPI0610048-1A patent/BRPI0610048A2/pt not_active Application Discontinuation
- 2006-05-13 CA CA002609389A patent/CA2609389A1/en not_active Abandoned
- 2006-05-13 MX MX2007014726A patent/MX2007014726A/es not_active Application Discontinuation
-
2007
- 2007-11-20 IL IL187508A patent/IL187508A0/en unknown
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