JP2003510329A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003510329A5 JP2003510329A5 JP2001526545A JP2001526545A JP2003510329A5 JP 2003510329 A5 JP2003510329 A5 JP 2003510329A5 JP 2001526545 A JP2001526545 A JP 2001526545A JP 2001526545 A JP2001526545 A JP 2001526545A JP 2003510329 A5 JP2003510329 A5 JP 2003510329A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- rapamycin
- carbons
- silyl ether
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C**[C@](C(C(C(C)C[C@](C)C=CC=CC=C(C)[C@](CC(CCC1C)OC1(C(C(N(CCCC1)C1C(OCC(C)C)=O)=O)=O)O)OC)=O)OC)C(C)=CC(C)C(*)=O Chemical compound C**[C@](C(C(C(C)C[C@](C)C=CC=CC=C(C)[C@](CC(CCC1C)OC1(C(C(N(CCCC1)C1C(OCC(C)C)=O)=O)=O)O)OC)=O)OC)C(C)=CC(C)C(*)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40883099A | 1999-09-29 | 1999-09-29 | |
| US09/408,830 | 1999-09-29 | ||
| PCT/US2000/026445 WO2001023395A2 (en) | 1999-09-29 | 2000-09-27 | Regioselective synthesis of rapamycin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003510329A JP2003510329A (ja) | 2003-03-18 |
| JP2003510329A5 true JP2003510329A5 (https=) | 2008-02-21 |
| JP4289813B2 JP4289813B2 (ja) | 2009-07-01 |
Family
ID=23617953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001526545A Expired - Fee Related JP4289813B2 (ja) | 1999-09-29 | 2000-09-27 | ラパマイシン誘導体のレギオ選択的な合成 |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1216251B1 (https=) |
| JP (1) | JP4289813B2 (https=) |
| KR (1) | KR100754236B1 (https=) |
| CN (1) | CN1176925C (https=) |
| AR (1) | AR029181A1 (https=) |
| AT (1) | ATE233269T1 (https=) |
| AU (1) | AU782234B2 (https=) |
| BR (1) | BR0014433A (https=) |
| CA (1) | CA2385461C (https=) |
| CZ (1) | CZ300368B6 (https=) |
| DE (1) | DE60001510T2 (https=) |
| DK (1) | DK1216251T3 (https=) |
| EA (1) | EA004331B1 (https=) |
| ES (1) | ES2189768T3 (https=) |
| HK (1) | HK1044774B (https=) |
| HU (1) | HUP0202609A3 (https=) |
| IL (2) | IL148542A0 (https=) |
| MX (1) | MXPA02003243A (https=) |
| NO (1) | NO20021360D0 (https=) |
| NZ (1) | NZ517644A (https=) |
| PL (1) | PL200899B1 (https=) |
| TW (1) | TWI256395B (https=) |
| WO (1) | WO2001023395A2 (https=) |
| ZA (1) | ZA200201918B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| UA84881C2 (ru) * | 2003-09-03 | 2008-12-10 | Уайт | Аморфный 42-эфир рапамицина и 3-гидрокси-2-(гидроксиметил)-2-метилпропионовой кислоты и фармацевтическая композиция, содержащая его |
| AR046194A1 (es) | 2003-11-04 | 2005-11-30 | Mayo Foundation | Metodo de tratamiento del linfoma de celulas del manto |
| JP4224115B2 (ja) * | 2004-04-14 | 2009-02-12 | ワイス | ラパマイシン４２−エステル誘導体の位置特異的合成 |
| MXPA06011883A (es) | 2004-04-14 | 2006-12-14 | Wyeth Corp | 42-ester de prolina-rapamicina con acido 2,2-bis(hidroximetil)propionico y sintesis enzimatica de dos etapas de 42-ester de prolina-rapamicina con acido 2,2-bis(hidroximetil)propionico y 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionic |
| CA2577011A1 (en) | 2004-08-10 | 2006-04-13 | Wyeth | Cci-779 derivatives and methods of making same |
| KR101313702B1 (ko) | 2005-02-03 | 2013-10-04 | 와이어쓰 | 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물 |
| CA2595766A1 (en) | 2005-02-09 | 2006-08-17 | Wyeth | Cci-779 polymorph and use thereof |
| EP1942937A1 (en) | 2005-11-04 | 2008-07-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| BRPI0914790A2 (pt) | 2008-06-17 | 2015-10-20 | Wyeth Llc | uso de um composto de vinorelbina e um composto de hki-272, composição farmacêutica e produto e kit para o tratamento de neoplasma |
| CN101676291B (zh) | 2008-09-18 | 2012-05-09 | 上海海和药物研究开发有限公司 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
| WO2011092564A2 (en) * | 2010-01-28 | 2011-08-04 | Fresenius Kabi Oncology Ltd | Process for the preparation of temsirolimus and its intermediates |
| CN102020662B (zh) | 2011-01-07 | 2013-02-13 | 天津市炜杰科技有限公司 | 一种驮瑞塞尔制备方法 |
| WO2012131019A1 (en) * | 2011-04-01 | 2012-10-04 | Sandoz Ag | Regioselective acylation of rapamycin at the c-42 position |
| CN103421023B (zh) * | 2013-07-30 | 2015-09-23 | 福建省微生物研究所 | 一种替西罗莫司的合成工艺 |
| CN104086564B (zh) * | 2014-07-30 | 2019-02-05 | 江苏奥赛康药业股份有限公司 | 一种高纯度坦罗莫司的制备方法 |
| CN106146536B (zh) * | 2015-04-25 | 2019-07-26 | 山东新时代药业有限公司 | 一种依维莫司的制备方法 |
| WO2017158499A1 (en) * | 2016-03-14 | 2017-09-21 | Wisconsin Alumni Research Foundation | Oligolactic acid conjugates and micelles with enhanced anticancer efficacy |
| CN107561170B (zh) * | 2016-07-02 | 2021-07-30 | 山东新时代药业有限公司 | 一种坦西莫司中间体的分析检测方法 |
| CN108948045A (zh) * | 2017-05-20 | 2018-12-07 | 鲁南制药集团股份有限公司 | 一种替西罗莫司的制备方法 |
| CN108948046B (zh) * | 2017-05-20 | 2020-11-10 | 鲁南制药集团股份有限公司 | 一种替西罗莫司的中间体及其制备方法 |
| CN109206441B (zh) * | 2017-06-30 | 2022-05-20 | 正大天晴药业集团股份有限公司 | 一种依维莫司的纯化方法 |
| CN109776570A (zh) * | 2017-11-14 | 2019-05-21 | 上海医药工业研究院 | 一种依维莫司中间体、其制备方法及其应用 |
| WO2019241789A1 (en) | 2018-06-15 | 2019-12-19 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
| CN109369679A (zh) * | 2018-12-24 | 2019-02-22 | 江苏卓和药业有限公司 | 一种雷帕霉素的精制方法 |
| CN109851626B (zh) * | 2019-01-08 | 2021-11-02 | 扬子江药业集团四川海蓉药业有限公司 | 一种替西罗莫司的分离纯化方法 |
| AU2020397938A1 (en) | 2019-12-05 | 2022-06-23 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
| CN113372359A (zh) * | 2020-03-10 | 2021-09-10 | 鲁南制药集团股份有限公司 | 一种坦西莫司的制备方法 |
| CN114106014B (zh) * | 2020-08-27 | 2024-03-15 | 鲁南制药集团股份有限公司 | 一种依维莫司的制备方法 |
| CN115028658A (zh) * | 2022-07-06 | 2022-09-09 | 国药集团川抗制药有限公司 | 雷帕霉素硅醇酯及其制备方法和应用 |
| GB202415232D0 (en) | 2024-10-16 | 2024-11-27 | Nacamed As | Composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5387680A (en) * | 1993-08-10 | 1995-02-07 | American Home Products Corporation | C-22 ring stabilized rapamycin derivatives |
| US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| US5563145A (en) * | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
-
2000
- 2000-09-14 TW TW089118799A patent/TWI256395B/zh active
- 2000-09-27 ES ES00966904T patent/ES2189768T3/es not_active Expired - Lifetime
- 2000-09-27 WO PCT/US2000/026445 patent/WO2001023395A2/en not_active Ceased
- 2000-09-27 JP JP2001526545A patent/JP4289813B2/ja not_active Expired - Fee Related
- 2000-09-27 AT AT00966904T patent/ATE233269T1/de not_active IP Right Cessation
- 2000-09-27 CZ CZ20021136A patent/CZ300368B6/cs not_active IP Right Cessation
- 2000-09-27 CN CNB008163685A patent/CN1176925C/zh not_active Expired - Fee Related
- 2000-09-27 PL PL354461A patent/PL200899B1/pl not_active IP Right Cessation
- 2000-09-27 BR BR0014433-9A patent/BR0014433A/pt not_active IP Right Cessation
- 2000-09-27 HU HU0202609A patent/HUP0202609A3/hu unknown
- 2000-09-27 IL IL14854200A patent/IL148542A0/xx active IP Right Grant
- 2000-09-27 AR ARP000105064A patent/AR029181A1/es unknown
- 2000-09-27 DE DE60001510T patent/DE60001510T2/de not_active Expired - Lifetime
- 2000-09-27 DK DK00966904T patent/DK1216251T3/da active
- 2000-09-27 CA CA002385461A patent/CA2385461C/en not_active Expired - Fee Related
- 2000-09-27 AU AU77182/00A patent/AU782234B2/en not_active Ceased
- 2000-09-27 MX MXPA02003243A patent/MXPA02003243A/es active IP Right Grant
- 2000-09-27 EA EA200200412A patent/EA004331B1/ru not_active IP Right Cessation
- 2000-09-27 NZ NZ517644A patent/NZ517644A/en unknown
- 2000-09-27 HK HK02106469.7A patent/HK1044774B/en not_active IP Right Cessation
- 2000-09-27 EP EP00966904A patent/EP1216251B1/en not_active Expired - Lifetime
- 2000-09-27 KR KR1020027004033A patent/KR100754236B1/ko not_active Expired - Fee Related
-
2002
- 2002-03-06 IL IL148542A patent/IL148542A/en not_active IP Right Cessation
- 2002-03-07 ZA ZA200201918A patent/ZA200201918B/en unknown
- 2002-03-19 NO NO20021360A patent/NO20021360D0/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003510329A5 (https=) | ||
| JP4289813B2 (ja) | ラパマイシン誘導体のレギオ選択的な合成 | |
| US6277983B1 (en) | Regioselective synthesis of rapamycin derivatives | |
| JPH0578377A (ja) | ラパマイシンのシリルエーテル類 | |
| JP2018150331A5 (https=) | ||
| JP5117390B2 (ja) | メイタンシノールの調製法 | |
| JP2015517402A5 (https=) | ||
| KR950703567A (ko) | O-알킬화된 라파미신 유도체 및 면역 억제제로서의 용도 (o-alkylated rapamycin derivatives and their use, particularly as immuno-suppressants) | |
| WO2012048058A3 (en) | Developing potent urate transporter inhibitors: compounds designed for their uricosuric action | |
| JP2012522793A5 (https=) | ||
| JP2008542214A5 (https=) | ||
| JP2018528244A5 (https=) | ||
| JP2013136631A5 (https=) | ||
| JP2019516720A5 (https=) | ||
| JP2006528667A5 (https=) | ||
| JP2008526950A5 (https=) | ||
| EP2222338B1 (de) | Stabilisierung öliger suspensionen enthaltend hydrophobe kieselsäuren | |
| ATE535538T1 (de) | Verfahren zur herstellung von guggulsteronen und guggulsterol | |
| JP2004536170A5 (https=) | ||
| KR830006306A (ko) | α-치환 우레이도 벤질 페니실린 유도체의 제조방법 | |
| CA2584052A1 (en) | Process for the esterification of a carbothioic acid | |
| WO2006063757A3 (de) | Wasserfreie metalloxidkolloide und metalloxidpolymere, verfahren zu deren herstellung und verwendung | |
| RU2022101085A (ru) | Антагонист нейрокинина-1 | |
| JP2001519332A (ja) | カルバペネム中間体の合成方法、および製造された化合物 |