JP2008542205A - ４−ビフェニリルアゼチジン−２−オンの製造方法 - Google Patents

４−ビフェニリルアゼチジン−２−オンの製造方法 Download PDF

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Publication number
JP2008542205A
JP2008542205A JP2008510309A JP2008510309A JP2008542205A JP 2008542205 A JP2008542205 A JP 2008542205A JP 2008510309 A JP2008510309 A JP 2008510309A JP 2008510309 A JP2008510309 A JP 2008510309A JP 2008542205 A JP2008542205 A JP 2008542205A
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Prior art keywords
group
formula
ether group
benzyl
ether
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Pending
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Japanese (ja)
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JP2008542205A5 (cg-RX-API-DMAC10.html
Inventor
ピーター リー
ステファン アントネッリ
レジーナ ランドリガン−サウシー
エデュアルド ジェー． マルティネス
ウェイン シェイラー
ジョン ジェー． タレー
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Microbia Inc
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Microbia Inc
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Publication of JP2008542205A publication Critical patent/JP2008542205A/ja
Publication of JP2008542205A5 publication Critical patent/JP2008542205A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
JP2008510309A 2005-05-06 2006-05-08 ４−ビフェニリルアゼチジン−２−オンの製造方法 Pending JP2008542205A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67833605P 2005-05-06 2005-05-06
US72692905P 2005-10-14 2005-10-14
PCT/US2006/017706 WO2006122020A2 (en) 2005-05-06 2006-05-08 Process for production of 4-biphenylyazetidin-2-ones

Publications (2)

Publication Number Publication Date
JP2008542205A true JP2008542205A (ja) 2008-11-27
JP2008542205A5 JP2008542205A5 (cg-RX-API-DMAC10.html) 2009-07-30

Family

ID=37101971

Family Applications (1)

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JP2008510309A Pending JP2008542205A (ja) 2005-05-06 2006-05-08 ４−ビフェニリルアゼチジン−２−オンの製造方法

Country Status (14)

Country Link
US (1) US20080287663A1 (cg-RX-API-DMAC10.html)
EP (1) EP1893571A2 (cg-RX-API-DMAC10.html)
JP (1) JP2008542205A (cg-RX-API-DMAC10.html)
KR (1) KR20080011687A (cg-RX-API-DMAC10.html)
AU (1) AU2006244212A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0611045A2 (cg-RX-API-DMAC10.html)
CA (1) CA2607939A1 (cg-RX-API-DMAC10.html)
EA (1) EA200702428A1 (cg-RX-API-DMAC10.html)
IL (1) IL187155A0 (cg-RX-API-DMAC10.html)
MA (1) MA29496B1 (cg-RX-API-DMAC10.html)
MX (1) MX2007013872A (cg-RX-API-DMAC10.html)
NO (1) NO20076161L (cg-RX-API-DMAC10.html)
TW (1) TW200726746A (cg-RX-API-DMAC10.html)
WO (1) WO2006122020A2 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540557A (ja) * 2005-05-11 2008-11-20 マイクロビア インコーポレーテッド フェノール型４−ビフェニリルアゼチジン−２−オンの製造方法
JP2008545700A (ja) * 2005-05-25 2008-12-18 マイクロビア インコーポレーテッド ４−（ビフェニリル）アゼチジン−２−オンホスホン酸類の製造方法
JP2013501734A (ja) * 2009-08-11 2013-01-17 チュージャン・ヒスン・ファーマシューティカル・カンパニー・リミテッド アゼチジノン化合物およびその医薬用法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608108A1 (en) * 2005-05-09 2006-11-16 Microbia, Inc. Organometal benzenephosphonate coupling agents
WO2008061238A2 (en) * 2006-11-16 2008-05-22 Ironwood Pharmaceuticals, Inc. Processes for production of 4-biphenylyazetidin-2-ones
WO2013152476A1 (en) 2012-04-10 2013-10-17 Theracos, Inc. Process for the preparation of benzylbenzene sglt2 inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508637A (ja) * 1991-07-23 1994-09-29 シェリング・コーポレーション 血清コレステロール低下薬として有用な置換β−ラクタム化合物およびそれらの製法
WO2002066464A1 (fr) * 2001-02-23 2002-08-29 Kotobuki Pharmaceutical Co., Ltd. Composes de beta-lactame, leur procede de production et agents d'abaissement du taux de cholesterol contenant ces composes
JP2004516280A (ja) * 2000-12-21 2004-06-03 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規な１，２−ジフェニルアゼチジノン、その調製方法、その化合物を含む薬剤、および脂質代謝障害を治療するためのその使用
JP2005053931A (ja) * 1998-12-07 2005-03-03 Schering Plough Corp アゼチジノンの合成プロセス

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US3794734A (en) 1971-03-03 1974-02-26 Merck & Co Inc Methods of treating edema and hypertension using certain 2-aminoethylphenols
US5561227A (en) * 1991-07-23 1996-10-01 Schering Corporation Process for the stereospecific synthesis of azetidinones
US5688787A (en) * 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
CA2158191A1 (en) * 1994-09-16 1996-03-17 Junji Yokoi Method for preventing settlement of aquatic fouling organisms
US5656624A (en) * 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
US5756470A (en) 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6207822B1 (en) * 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
IL156552A0 (en) 2000-12-21 2004-01-04 Aventis Pharma Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
BRPI0208384B1 (pt) * 2001-03-28 2016-05-31 Merck Sharp & Dohme síntese enantiosseletiva de compostos intermediários de azetidinona
TWI254635B (en) * 2002-08-05 2006-05-11 Yamanouchi Pharma Co Ltd Azulene derivative and salt thereof
WO2004099132A2 (en) 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Process for the preparation of trans-isomers of diphenylazetidinone derivatives
DE602004008100T2 (de) * 2003-11-10 2008-04-30 Microbia Inc., Cambridge 4-biarylyl-1-phenylazetidin-2-one
AU2006244043A1 (en) * 2005-05-11 2006-11-16 Microbia, Inc. Processes for production of phenolic 4-biphenylylazetidin-2-ones

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508637A (ja) * 1991-07-23 1994-09-29 シェリング・コーポレーション 血清コレステロール低下薬として有用な置換β−ラクタム化合物およびそれらの製法
JP2005053931A (ja) * 1998-12-07 2005-03-03 Schering Plough Corp アゼチジノンの合成プロセス
JP2004516280A (ja) * 2000-12-21 2004-06-03 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規な１，２−ジフェニルアゼチジノン、その調製方法、その化合物を含む薬剤、および脂質代謝障害を治療するためのその使用
WO2002066464A1 (fr) * 2001-02-23 2002-08-29 Kotobuki Pharmaceutical Co., Ltd. Composes de beta-lactame, leur procede de production et agents d'abaissement du taux de cholesterol contenant ces composes

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JPN6012021809; ＣＬＡＤＥＲ，Ｊ．Ｗ．　ｅｔ　ａｌ: '２-Ａｚｅｔｉｄｉｎｏｎｅ　Ｃｈｏｌｅｓｔｅｒｏｌ　Ａｂｓｏｒｐｔｉｏｎ　Ｉｎｈｉｂｉｔｏｒｓ：　Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ　Ｒｅｌａｔｉｏｎｓｈｉｐｓ　ｏｎ　ｔｈｅ　Ｈｅｔｅｒｏｃｙｃｌｉ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３９，　Ｎｏ．１９, 1996, ｐ．３６８４-３６９３ *
JPN6012021811; ＶＡＣＣＡＲＯ，Ｗ．Ｄ．　ｅｔ　ａｌ: '２-ａｚｅｔｉｄｉｎｏｎｅ　ｃｈｏｌｅｓｔｅｒｏｌ　ａｂｓｏｒｐｔｉｏｎ　ｉｎｈｉｂｉｔｏｒｓ：　ｉｎｃｒｅａｓｅｄ　ｐｏｔｅｎｃｙ　ｂｙ　ｓｕｂｓｔｉｔｕｔｉｏｎ　ｏｆ　ｔｈｅ　Ｃ-４　ｐｈｅｎｙｌ' Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６，　Ｎｏ．９, 1998, ｐ．１４２９-１４３７ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540557A (ja) * 2005-05-11 2008-11-20 マイクロビア インコーポレーテッド フェノール型４−ビフェニリルアゼチジン−２−オンの製造方法
JP2008545700A (ja) * 2005-05-25 2008-12-18 マイクロビア インコーポレーテッド ４−（ビフェニリル）アゼチジン−２−オンホスホン酸類の製造方法
JP2013501734A (ja) * 2009-08-11 2013-01-17 チュージャン・ヒスン・ファーマシューティカル・カンパニー・リミテッド アゼチジノン化合物およびその医薬用法

Also Published As

Publication number Publication date
WO2006122020A3 (en) 2007-05-18
MA29496B1 (fr) 2008-05-02
NO20076161L (no) 2007-11-29
AU2006244212A1 (en) 2006-11-16
EA200702428A1 (ru) 2008-04-28
EP1893571A2 (en) 2008-03-05
WO2006122020A2 (en) 2006-11-16
BRPI0611045A2 (pt) 2010-08-10
US20080287663A1 (en) 2008-11-20
CA2607939A1 (en) 2006-11-16
KR20080011687A (ko) 2008-02-05
TW200726746A (en) 2007-07-16
IL187155A0 (en) 2008-02-09
MX2007013872A (es) 2008-04-02

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