JP2008541733A5 - - Google Patents

Info

Publication number

JP2008541733A5

JP2008541733A5 JP2008513805A JP2008513805A JP2008541733A5 JP 2008541733 A5 JP2008541733 A5 JP 2008541733A5 JP 2008513805 A JP2008513805 A JP 2008513805A JP 2008513805 A JP2008513805 A JP 2008513805A JP 2008541733 A5 JP2008541733 A5 JP 2008541733A5

Authority

JP

Japan

Prior art keywords

seq

antigen

antibody

amino acid

antibody fragment

Prior art date

2006-05-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 37
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 37
• 239000000427 antigen Substances 0.000 claims 36
• 102000036639 antigens Human genes 0.000 claims 36
• 108091007433 antigens Proteins 0.000 claims 36
• 125000003275 alpha amino acid group Chemical group 0.000 claims 30
• 102000040430 polynucleotide Human genes 0.000 claims 11
• 108091033319 polynucleotide Proteins 0.000 claims 11
• 239000002157 polynucleotide Substances 0.000 claims 11
• 239000003814 drug Substances 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 7
• 101150013553 CD40 gene Proteins 0.000 claims 6
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 208000035475 disorder Diseases 0.000 claims 4
• 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 108010044540 auristatin Proteins 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 208000026278 immune system disease Diseases 0.000 claims 2
• MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
• 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
• 208000017604 Hodgkin disease Diseases 0.000 claims 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 206010042971 T-cell lymphoma Diseases 0.000 claims 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 210000003443 bladder cell Anatomy 0.000 claims 1
• 210000002449 bone cell Anatomy 0.000 claims 1
• 210000000481 breast Anatomy 0.000 claims 1
• 230000024245 cell differentiation Effects 0.000 claims 1
• 230000010261 cell growth Effects 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 210000003128 head Anatomy 0.000 claims 1
• 210000004408 hybridoma Anatomy 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000002955 isolation Methods 0.000 claims 1
• 210000003292 kidney cell Anatomy 0.000 claims 1
• 210000005265 lung cell Anatomy 0.000 claims 1
• 210000003739 neck Anatomy 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 230000002093 peripheral effect Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 210000005267 prostate cell Anatomy 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 210000004927 skin cell Anatomy 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1