JP2008540532A5 - - Google Patents
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- Publication number
- JP2008540532A5 JP2008540532A5 JP2008511214A JP2008511214A JP2008540532A5 JP 2008540532 A5 JP2008540532 A5 JP 2008540532A5 JP 2008511214 A JP2008511214 A JP 2008511214A JP 2008511214 A JP2008511214 A JP 2008511214A JP 2008540532 A5 JP2008540532 A5 JP 2008540532A5
- Authority
- JP
- Japan
- Prior art keywords
- nonionic surfactant
- composition
- glycol
- meloxapol
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002736 nonionic surfactant Substances 0.000 claims 30
- 239000000203 mixture Substances 0.000 claims 29
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 15
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 15
- 229960000502 poloxamer Drugs 0.000 claims 15
- 229920001983 poloxamer Polymers 0.000 claims 15
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 8
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- QEFAQIPZVLVERP-UHFFFAOYSA-N nepafenac Chemical compound NC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1N QEFAQIPZVLVERP-UHFFFAOYSA-N 0.000 claims 5
- 229960001002 nepafenac Drugs 0.000 claims 5
- 239000008181 tonicity modifier Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000003732 agents acting on the eye Substances 0.000 claims 4
- 229940023490 ophthalmic product Drugs 0.000 claims 4
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 2
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 claims 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 2
- 239000004386 Erythritol Substances 0.000 claims 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000022873 Ocular disease Diseases 0.000 claims 2
- 206010038935 Retinopathy sickle cell Diseases 0.000 claims 2
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 2
- 229940009714 erythritol Drugs 0.000 claims 2
- 235000019414 erythritol Nutrition 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 claims 2
- 229940100654 ophthalmic suspension Drugs 0.000 claims 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims 2
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 2
- -1 1,3-butylene Chemical group 0.000 claims 1
- 229940058015 1,3-butylene glycol Drugs 0.000 claims 1
- 229940122072 Carbonic anhydrase inhibitor Drugs 0.000 claims 1
- 206010055665 Corneal neovascularisation Diseases 0.000 claims 1
- 206010058202 Cystoid macular oedema Diseases 0.000 claims 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 201000002154 Pterygium Diseases 0.000 claims 1
- 201000007527 Retinal artery occlusion Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010039705 Scleritis Diseases 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000007900 aqueous suspension Substances 0.000 claims 1
- 229960000722 brinzolamide Drugs 0.000 claims 1
- HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- LVGQIQHJMRUCRM-UHFFFAOYSA-L calcium bisulfite Chemical compound [Ca+2].OS([O-])=O.OS([O-])=O LVGQIQHJMRUCRM-UHFFFAOYSA-L 0.000 claims 1
- 235000010260 calcium hydrogen sulphite Nutrition 0.000 claims 1
- GBAOBIBJACZTNA-UHFFFAOYSA-L calcium sulfite Chemical compound [Ca+2].[O-]S([O-])=O GBAOBIBJACZTNA-UHFFFAOYSA-L 0.000 claims 1
- 235000010261 calcium sulphite Nutrition 0.000 claims 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 150000003841 chloride salts Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000000159 corneal neovascularization Diseases 0.000 claims 1
- 201000010206 cystoid macular edema Diseases 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims 1
- 206010014801 endophthalmitis Diseases 0.000 claims 1
- 229960001048 fluorometholone Drugs 0.000 claims 1
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 230000000642 iatrogenic effect Effects 0.000 claims 1
- 201000004614 iritis Diseases 0.000 claims 1
- 206010023332 keratitis Diseases 0.000 claims 1
- 229960001798 loteprednol Drugs 0.000 claims 1
- YPZVAYHNBBHPTO-MXRBDKCISA-N loteprednol Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)OCCl)[C@@H]4[C@@H]3CCC2=C1 YPZVAYHNBBHPTO-MXRBDKCISA-N 0.000 claims 1
- LPHFLPKXBKBHRW-UHFFFAOYSA-L magnesium;hydrogen sulfite Chemical compound [Mg+2].OS([O-])=O.OS([O-])=O LPHFLPKXBKBHRW-UHFFFAOYSA-L 0.000 claims 1
- JESHZQPNPCJVNG-UHFFFAOYSA-L magnesium;sulfite Chemical compound [Mg+2].[O-]S([O-])=O JESHZQPNPCJVNG-UHFFFAOYSA-L 0.000 claims 1
- 229910001510 metal chloride Inorganic materials 0.000 claims 1
- 235000010298 natamycin Nutrition 0.000 claims 1
- 239000004311 natamycin Substances 0.000 claims 1
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 claims 1
- 229960003255 natamycin Drugs 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- DJEHXEMURTVAOE-UHFFFAOYSA-M potassium bisulfite Chemical compound [K+].OS([O-])=O DJEHXEMURTVAOE-UHFFFAOYSA-M 0.000 claims 1
- 229940099427 potassium bisulfite Drugs 0.000 claims 1
- 235000010259 potassium hydrogen sulphite Nutrition 0.000 claims 1
- BHZRJJOHZFYXTO-UHFFFAOYSA-L potassium sulfite Chemical compound [K+].[K+].[O-]S([O-])=O BHZRJJOHZFYXTO-UHFFFAOYSA-L 0.000 claims 1
- 235000019252 potassium sulphite Nutrition 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 1
- 210000001957 retinal vein Anatomy 0.000 claims 1
- 208000004644 retinal vein occlusion Diseases 0.000 claims 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 1
- 229960002586 roflumilast Drugs 0.000 claims 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- 229940001584 sodium metabisulfite Drugs 0.000 claims 1
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 1
- 235000010265 sodium sulphite Nutrition 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67933205P | 2005-05-10 | 2005-05-10 | |
| US60/679,332 | 2005-05-10 | ||
| PCT/US2006/017606 WO2006121963A2 (en) | 2005-05-10 | 2006-05-08 | Suspension formulations comprising an active principle, a poloxamer or meroxapol surfactant and a glycol, its use for the manufacture of a medicament for treating ophthalmic disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540532A JP2008540532A (ja) | 2008-11-20 |
| JP2008540532A5 true JP2008540532A5 (https=) | 2009-04-16 |
| JP4968954B2 JP4968954B2 (ja) | 2012-07-04 |
Family
ID=37081695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511214A Expired - Fee Related JP4968954B2 (ja) | 2005-05-10 | 2006-05-08 | 活性成分、ポロキサマー界面活性剤もしくはメロキサポール界面活性剤およびグリコールを含有する懸濁処方物、ならびに眼の障害を処置するための医薬の製造のためのその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20060257487A1 (https=) |
| EP (1) | EP1885336B1 (https=) |
| JP (1) | JP4968954B2 (https=) |
| KR (1) | KR20080011310A (https=) |
| CN (1) | CN101175475B (https=) |
| AT (1) | ATE428401T1 (https=) |
| AU (1) | AU2006244244B2 (https=) |
| BR (1) | BRPI0609227A2 (https=) |
| CA (1) | CA2607608A1 (https=) |
| CY (1) | CY1109117T1 (https=) |
| DE (1) | DE602006006308D1 (https=) |
| DK (1) | DK1885336T3 (https=) |
| ES (1) | ES2322200T3 (https=) |
| MX (1) | MX2007014083A (https=) |
| PL (1) | PL1885336T3 (https=) |
| PT (1) | PT1885336E (https=) |
| SI (1) | SI1885336T1 (https=) |
| WO (1) | WO2006121963A2 (https=) |
| ZA (1) | ZA200709251B (https=) |
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| US20070254841A1 (en) * | 2006-01-25 | 2007-11-01 | Ophthalmic Research Associates, Inc. | Formulations and methods for treating dry eye |
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| WO2008153746A1 (en) * | 2007-05-24 | 2008-12-18 | Aciex Therapeutics, Inc. | Formulations and methods for treating dry eye |
| TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
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| US8912236B2 (en) * | 2009-03-03 | 2014-12-16 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye |
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| KR20140048218A (ko) | 2011-06-28 | 2014-04-23 | 바이엘 헬스케어 엘엘씨 | 레고라페닙을 함유하는 국소 안과용 약학 조성물 |
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| GR1007906B (el) * | 2012-03-22 | 2013-05-30 | Φαρματεν Αβεε, | Οφθαλμικο φαρμακευτικο σκευασμα περιεχον ενα αναστολεα καρβονικης ανυδρασης και μεθοδος για την παρασκευη αυτου |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| ES3055223T3 (en) | 2012-05-03 | 2026-02-10 | Alcon Inc | Pharmaceutical nanoparticles showing improved mucosal transport |
| JP6360039B2 (ja) | 2012-05-03 | 2018-07-18 | カラ ファーマシューティカルズ インコーポレイテッド | 複数の被覆された粒子を含む組成物、医薬組成物、医薬製剤、及び当該粒子の形成方法 |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| WO2013188283A1 (en) | 2012-06-12 | 2013-12-19 | Bayer Healthcare Llc | Topical ophthalmological pharmaceutical composition containing sunitinib |
| UY35183A (es) | 2012-12-21 | 2014-07-31 | Bayer Healthcare Llc | Composición farmacéutica oftalmológica tópica que contiene regorafenib |
| EP2956138B1 (en) | 2013-02-15 | 2022-06-22 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| MX368903B (es) | 2013-02-20 | 2019-10-21 | Kala Pharmaceuticals Inc | Compuestos terapéuticos y sus usos en el tratamiento de enfermedades proliferativas. |
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| MX383077B (es) * | 2013-07-22 | 2025-03-13 | Novel Drug Solutions Llc | Composiciones farmaceuticas para la administracion intraocular que comprenden un agente antibacteriano y un agente antiinflamatorio. |
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| CN104706579A (zh) * | 2015-03-12 | 2015-06-17 | 广州仁恒医药科技有限公司 | 一种夫西地酸滴眼液及其制备方法 |
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| US12102622B2 (en) | 2021-02-10 | 2024-10-01 | Iolyx Therapeutics, Inc. | Methods for ophthalmic delivery of roflumilast |
| KR102356603B1 (ko) * | 2021-08-05 | 2022-02-08 | 지엘팜텍주식회사 | 안구건조증 치료를 위한 레코플라본 함유 점안 조성물 |
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| US6037328A (en) * | 1998-12-22 | 2000-03-14 | Bausch & Lomb Incorporated | Method and composition for rewetting and preventing deposits on contact lens |
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| EP1249249A1 (en) * | 2000-12-12 | 2002-10-16 | Menicon Co., Ltd. | Ophthalmic composition |
| AR030346A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
| PE20020578A1 (es) * | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
| JP2002332225A (ja) * | 2001-05-09 | 2002-11-22 | Lion Corp | 眼科用組成物 |
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| JP2003176228A (ja) * | 2001-12-11 | 2003-06-24 | Rohto Pharmaceut Co Ltd | 液 剤 |
| US20030133905A1 (en) * | 2001-12-20 | 2003-07-17 | Zhenze Hu | Composition for treating contact lenses in the eye |
| US6765001B2 (en) * | 2001-12-21 | 2004-07-20 | Medicis Pharmaceutical Corporation | Compositions and methods for enhancing corticosteroid delivery |
| US7119112B2 (en) * | 2002-02-28 | 2006-10-10 | Icagen, Inc. | Sulfonamides as potassium channel blockers |
| US20040029771A1 (en) * | 2002-02-28 | 2004-02-12 | Icagen, Inc. | Methods for treating diseases related to intraocular pressure |
| US20040115270A1 (en) * | 2002-12-13 | 2004-06-17 | Dharmendra Jani | Absorption and controlled release of polyethers from hydrogel biomaterials |
| TWI358290B (en) * | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| DK1906916T3 (da) * | 2005-05-10 | 2009-01-19 | Alcon Inc | Oftalmisk suspension, der omfatter et oftalmisk lægemiddel, en poloxamin og et tonicitetsregulerende glycolbaseret middel, anvendelse af sammensætningen til fremstilling af et medikament til behandling af oftalmiske lidelser |
-
2006
- 2006-05-08 BR BRPI0609227-6A patent/BRPI0609227A2/pt not_active IP Right Cessation
- 2006-05-08 SI SI200630323T patent/SI1885336T1/sl unknown
- 2006-05-08 DE DE602006006308T patent/DE602006006308D1/de not_active Expired - Lifetime
- 2006-05-08 US US11/430,239 patent/US20060257487A1/en not_active Abandoned
- 2006-05-08 DK DK06759258T patent/DK1885336T3/da active
- 2006-05-08 PT PT06759258T patent/PT1885336E/pt unknown
- 2006-05-08 ZA ZA200709251A patent/ZA200709251B/xx unknown
- 2006-05-08 CA CA002607608A patent/CA2607608A1/en not_active Abandoned
- 2006-05-08 KR KR1020077027974A patent/KR20080011310A/ko not_active Ceased
- 2006-05-08 AU AU2006244244A patent/AU2006244244B2/en not_active Ceased
- 2006-05-08 JP JP2008511214A patent/JP4968954B2/ja not_active Expired - Fee Related
- 2006-05-08 ES ES06759258T patent/ES2322200T3/es not_active Expired - Lifetime
- 2006-05-08 AT AT06759258T patent/ATE428401T1/de active
- 2006-05-08 EP EP06759258A patent/EP1885336B1/en not_active Expired - Lifetime
- 2006-05-08 WO PCT/US2006/017606 patent/WO2006121963A2/en not_active Ceased
- 2006-05-08 CN CN2006800161308A patent/CN101175475B/zh not_active Expired - Fee Related
- 2006-05-08 MX MX2007014083A patent/MX2007014083A/es active IP Right Grant
- 2006-05-08 PL PL06759258T patent/PL1885336T3/pl unknown
-
2009
- 2009-05-29 CY CY20091100579T patent/CY1109117T1/el unknown
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