JP2008539273A5 - - Google Patents

Info

Publication number

JP2008539273A5

JP2008539273A5 JP2008509175A JP2008509175A JP2008539273A5 JP 2008539273 A5 JP2008539273 A5 JP 2008539273A5 JP 2008509175 A JP2008509175 A JP 2008509175A JP 2008509175 A JP2008509175 A JP 2008509175A JP 2008539273 A5 JP2008539273 A5 JP 2008539273A5

Authority

JP

Japan

Prior art keywords

aag

prodrug

treatment

dose

proteasome inhibitor

Prior art date

2006-04-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• AYUNIORJHRXIBJ-TXHRRWQRSA-N tanespimycin Chemical compound N1C(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC2=C(NCC=C)C(=O)C=C1C2=O AYUNIORJHRXIBJ-TXHRRWQRSA-N 0.000 claims description 77
• XYFFWTYOFPSZRM-NBTLBREFSA-N [(3r,5r,6s,7r,8e,10r,11r,12z,14e)-21-amino-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate Chemical compound N1C(=O)\C(C)=C\C=C/[C@@H](OC)[C@H](OC(N)=O)\C(C)=C\[C@@H](C)[C@H](O)[C@H](OC)C[C@H](C)CC2=C(N)C(=O)C=C1C2=O XYFFWTYOFPSZRM-NBTLBREFSA-N 0.000 claims description 52
• 229940002612 prodrug Drugs 0.000 claims description 35
• 239000000651 prodrug Substances 0.000 claims description 35
• 229940079156 Proteasome inhibitor Drugs 0.000 claims description 23
• 239000003207 proteasome inhibitor Substances 0.000 claims description 23
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 22
• 201000000050 myeloid neoplasm Diseases 0.000 claims description 20
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims description 6
• 229960001467 bortezomib Drugs 0.000 claims description 4
• 208000034578 Multiple myelomas Diseases 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 1
• 238000000034 method Methods 0.000 description 48
• 210000004027 cell Anatomy 0.000 description 4
• 229940079593 drug Drugs 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• 230000003442 weekly effect Effects 0.000 description 3
• 101710163595 Chaperone protein DnaK Proteins 0.000 description 2
• 108010016626 Dipeptides Proteins 0.000 description 2
• 101710178376 Heat shock 70 kDa protein Proteins 0.000 description 2
• 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 2
• 230000006907 apoptotic process Effects 0.000 description 2
• 210000001185 bone marrow Anatomy 0.000 description 2
• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 108090000765 processed proteins & peptides Proteins 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 1
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1