JP2008539187A5 - - Google Patents
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- Publication number
- JP2008539187A5 JP2008539187A5 JP2008508169A JP2008508169A JP2008539187A5 JP 2008539187 A5 JP2008539187 A5 JP 2008539187A5 JP 2008508169 A JP2008508169 A JP 2008508169A JP 2008508169 A JP2008508169 A JP 2008508169A JP 2008539187 A5 JP2008539187 A5 JP 2008539187A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- mycobacterium
- mtb72f
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- 241000186359 Mycobacterium Species 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 201000008827 tuberculosis Diseases 0.000 claims 7
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 230000003053 immunization Effects 0.000 claims 3
- 238000002649 immunization Methods 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 230000005847 immunogenicity Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000007420 reactivation Effects 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 208000032420 Latent Infection Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229960003350 isoniazid Drugs 0.000 claims 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 1
- 229960001225 rifampicin Drugs 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67654905P | 2005-04-29 | 2005-04-29 | |
| US60/676,549 | 2005-04-29 | ||
| US77701706P | 2006-02-27 | 2006-02-27 | |
| US60/777,017 | 2006-02-27 | ||
| PCT/EP2006/004319 WO2006117240A2 (en) | 2005-04-29 | 2006-04-27 | Novel method for preventing or treating m tuberculosis infection |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011207361A Division JP2012065650A (ja) | 2005-04-29 | 2011-09-22 | 結核菌感染の予防または治療のための新規方法 |
| JP2012227192A Division JP5659207B2 (ja) | 2005-04-29 | 2012-10-12 | 結核菌感染の予防または治療のための新規方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008539187A JP2008539187A (ja) | 2008-11-13 |
| JP2008539187A5 true JP2008539187A5 (enExample) | 2009-06-18 |
| JP5164830B2 JP5164830B2 (ja) | 2013-03-21 |
Family
ID=36972897
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508169A Expired - Fee Related JP5164830B2 (ja) | 2005-04-29 | 2006-04-27 | 結核菌感染の予防または治療のための新規方法 |
| JP2011207361A Pending JP2012065650A (ja) | 2005-04-29 | 2011-09-22 | 結核菌感染の予防または治療のための新規方法 |
| JP2012227192A Expired - Fee Related JP5659207B2 (ja) | 2005-04-29 | 2012-10-12 | 結核菌感染の予防または治療のための新規方法 |
| JP2014217282A Pending JP2015057403A (ja) | 2005-04-29 | 2014-10-24 | 結核菌感染の予防または治療のための新規方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011207361A Pending JP2012065650A (ja) | 2005-04-29 | 2011-09-22 | 結核菌感染の予防または治療のための新規方法 |
| JP2012227192A Expired - Fee Related JP5659207B2 (ja) | 2005-04-29 | 2012-10-12 | 結核菌感染の予防または治療のための新規方法 |
| JP2014217282A Pending JP2015057403A (ja) | 2005-04-29 | 2014-10-24 | 結核菌感染の予防または治療のための新規方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (6) | US8470338B2 (enExample) |
| EP (3) | EP2457926B1 (enExample) |
| JP (4) | JP5164830B2 (enExample) |
| KR (4) | KR101352806B1 (enExample) |
| CN (3) | CN106390108B (enExample) |
| AT (1) | ATE543832T1 (enExample) |
| AU (1) | AU2006243357B2 (enExample) |
| BR (1) | BRPI0611347A2 (enExample) |
| CA (2) | CA2821389C (enExample) |
| CY (1) | CY1112851T1 (enExample) |
| DK (3) | DK2457926T3 (enExample) |
| EA (1) | EA012576B1 (enExample) |
| ES (3) | ES2381492T3 (enExample) |
| HR (3) | HRP20120331T1 (enExample) |
| IL (2) | IL186654A (enExample) |
| MA (1) | MA29678B1 (enExample) |
| NO (3) | NO340766B1 (enExample) |
| NZ (1) | NZ562729A (enExample) |
| PH (1) | PH12013502449A1 (enExample) |
| PL (3) | PL2457926T3 (enExample) |
| PT (3) | PT2426141E (enExample) |
| SI (3) | SI2426141T1 (enExample) |
| WO (1) | WO2006117240A2 (enExample) |
| ZA (1) | ZA200709209B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2457926T3 (pl) * | 2005-04-29 | 2015-03-31 | Glaxosmithkline Biologicals Sa | Nowy sposób profilaktyki lub leczenia zakażenia m. tuberculosis |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| EP1994409A2 (en) * | 2006-03-14 | 2008-11-26 | Oregon Health and Science University | Methods for producing an immune response to tuberculosis |
| US9717788B2 (en) | 2007-03-02 | 2017-08-01 | Glaxosmithkline Biologicals Sa | Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant |
| HUE031411T2 (en) | 2007-03-02 | 2017-07-28 | Glaxosmithkline Biologicals Sa | New Methods and Preparations |
| WO2009025820A2 (en) * | 2007-08-21 | 2009-02-26 | Stc. Unm | Rationally improved isoniazid and ethionamide derivatives and activity through selective isotopic substitution |
| WO2009158284A2 (en) * | 2008-06-26 | 2009-12-30 | Mayo Foundation For Medical Education And Research | Methods and materials for producing immune responses against polypeptides involved in antibiotic resistance |
| EP2315597B1 (en) | 2008-07-25 | 2017-08-23 | GlaxoSmithKline Biologicals S.A. | Novel compositions and methods |
| UA107330C2 (uk) | 2008-07-25 | 2014-12-25 | Глаксосмітклайн Байолоджікалз С.А. | Туберкульозний білок rv3616c та його застосування |
| WO2010010179A1 (en) | 2008-07-25 | 2010-01-28 | Glaxosmithkline Biologicals S.A. | The tuberculosis rv2386c protein, compositions and uses thereof |
| GB0815872D0 (en) | 2008-09-01 | 2008-10-08 | Pasteur Institut | Novel method and compositions |
| CN102413837B (zh) | 2009-04-24 | 2015-11-25 | 国立血清研究所 | 预防再激活的结核病tb疫苗 |
| PL2528621T3 (pl) | 2010-01-27 | 2017-07-31 | Glaxosmithkline Biologicals S.A. | Zmodyfikowane antygeny gruźlicy |
| HUE028452T2 (en) | 2010-12-14 | 2016-12-28 | Glaxosmithkline Biologicals Sa | Mycobacterium antigenic preparations |
| GB201022007D0 (en) | 2010-12-24 | 2011-02-02 | Imp Innovations Ltd | DNA-sensor |
| PL2661253T3 (pl) * | 2011-01-04 | 2017-08-31 | Archivel Farma, Sl | Preparat liposomowy odpowiedni do leczenia lub zapobiegania gruźlicy |
| GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| US20140349320A1 (en) * | 2011-12-15 | 2014-11-27 | The Trustees Of The University Of Pennsylvania | Using Adaptive Immunity to Detect Drug Resistance |
| ES2670493T3 (es) | 2012-01-12 | 2018-05-30 | Archivel Farma, S.L. | Vacuna de MTB-C contra respuestas alérgicas |
| WO2014042780A1 (en) * | 2012-08-03 | 2014-03-20 | Infectious Disease Research Institute | Compositions and methods for treating an active mycobacterium tuberculosis infection |
| WO2014047848A1 (en) * | 2012-09-27 | 2014-04-03 | Chengdu Yongan Pharmaceutical Co., Ltd. | Modified bcg strains with reduced or eliminated activity of lsr2 and pharmaceutical composition comprising same |
| CN102994595B (zh) * | 2012-11-30 | 2018-10-26 | 广州白云山拜迪生物医药有限公司 | 一种融合蛋白包涵体的制备方法 |
| CN102993266B (zh) * | 2012-11-30 | 2019-08-23 | 广州白云山拜迪生物医药有限公司 | 一种融合蛋白的纯化和复性方法 |
| GB201405921D0 (en) * | 2014-04-02 | 2014-05-14 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| US10588980B2 (en) * | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| US10335374B2 (en) | 2014-12-04 | 2019-07-02 | University System of Georgia, Valdosta State University | Tablet composition for anti-tuberculosis antibiotics |
| CN107615047A (zh) * | 2015-04-02 | 2018-01-19 | 比奥德赛公司 | 利用表面选择性非线性光学技术确定蛋白质结构的方法 |
| US10653679B2 (en) | 2015-05-04 | 2020-05-19 | Board Of Trustees Of Michigan State University | Compositions and methods for inhibiting bacterial growth |
| GB201513176D0 (en) * | 2015-07-27 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| CN110035770B (zh) | 2016-12-07 | 2023-06-16 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
| WO2019178472A1 (en) * | 2018-03-16 | 2019-09-19 | Washington University In St. Louis | Use of fatty acid oxidation inhibitors as antimicrobials |
| US11717519B2 (en) | 2017-04-21 | 2023-08-08 | Washington University In St. Louis | Use of fatty acid oxidation inhibitors as antimicrobials |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| WO2022119899A1 (en) * | 2020-12-02 | 2022-06-09 | Shionogi & Co., Ltd. | A medicament for treating mycobacterial infection characterized by combining a cytochrome bc1 inhibitor with clarithromycin or azithromycin |
| TW202328167A (zh) | 2021-08-31 | 2023-07-16 | 美商維爾生物科技股份有限公司 | 結核病疫苗 |
| KR102534846B1 (ko) | 2021-12-14 | 2023-05-19 | 재단법인 환동해산업연구원 | 결핵균에 항균 활성을 가지는 해조류 추출물 |
| CN116162141B (zh) * | 2022-11-30 | 2024-04-12 | 中国疾病预防控制中心传染病预防控制所 | 一种结核分枝杆菌抗原epcra013及其应用 |
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