JP2008538215A5 - - Google Patents
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- Publication number
- JP2008538215A5 JP2008538215A5 JP2008504422A JP2008504422A JP2008538215A5 JP 2008538215 A5 JP2008538215 A5 JP 2008538215A5 JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008538215 A5 JP2008538215 A5 JP 2008538215A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- administered
- caused
- modulator
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 31
- LAMQVIQMVKWXOC-UHFFFAOYSA-N 4-methyl-n-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide Chemical compound CC=1N=C(C=2C=NC=CC=2)SC=1C(=O)NC1=CC=CC=C1C(N=C1SC=2)=CN1C=2CN1CCOCC1 LAMQVIQMVKWXOC-UHFFFAOYSA-N 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 230000004064 dysfunction Effects 0.000 claims 6
- 230000002503 metabolic effect Effects 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 238000011287 therapeutic dose Methods 0.000 claims 5
- 230000000007 visual effect Effects 0.000 claims 5
- 210000001328 optic nerve Anatomy 0.000 claims 4
- 206010057430 Retinal injury Diseases 0.000 claims 3
- 102000011990 Sirtuin Human genes 0.000 claims 3
- 108050002485 Sirtuin Proteins 0.000 claims 3
- 239000012190 activator Substances 0.000 claims 3
- 230000004410 intraocular pressure Effects 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 2
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical group NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 2
- 208000028389 Nerve injury Diseases 0.000 claims 2
- 208000003435 Optic Neuritis Diseases 0.000 claims 2
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical group C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 230000008764 nerve damage Effects 0.000 claims 2
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 2
- 239000011618 nicotinamide riboside Substances 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 208000002177 Cataract Diseases 0.000 claims 1
- 208000018380 Chemical injury Diseases 0.000 claims 1
- 206010065319 Macular rupture Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66717905P | 2005-03-30 | 2005-03-30 | |
| US68425205P | 2005-05-25 | 2005-05-25 | |
| US11/374,278 US20070014833A1 (en) | 2005-03-30 | 2005-10-28 | Treatment of eye disorders with sirtuin modulators |
| PCT/US2006/011930 WO2006105403A2 (en) | 2005-03-30 | 2006-03-30 | Treatment of eye disorders with sirtuin modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538215A JP2008538215A (ja) | 2008-10-16 |
| JP2008538215A5 true JP2008538215A5 (https=) | 2009-04-09 |
Family
ID=37054169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504422A Pending JP2008538215A (ja) | 2005-03-30 | 2006-03-30 | サーチュイン活性化剤による眼障害の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070014833A1 (https=) |
| EP (1) | EP1863462A2 (https=) |
| JP (1) | JP2008538215A (https=) |
| AU (1) | AU2006230478B2 (https=) |
| CA (1) | CA2603009A1 (https=) |
| WO (1) | WO2006105403A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050158376A1 (en) * | 2003-10-23 | 2005-07-21 | Sardi William F. | Dietary supplement and method of processing same |
| US20090169585A1 (en) * | 2003-10-23 | 2009-07-02 | Resveratrol Partners, Llc | Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity |
| US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| WO2005069998A2 (en) * | 2004-01-20 | 2005-08-04 | Brigham Young University Technology Transfer Office | Novel sirtuin activating compounds and methods for making the same |
| US7522995B2 (en) | 2004-02-05 | 2009-04-21 | Nortrup Edward H | Method and system for providing travel time information |
| US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
| US20070212395A1 (en) * | 2006-03-08 | 2007-09-13 | Allergan, Inc. | Ocular therapy using sirtuin-activating agents |
| EP1850840A2 (en) * | 2005-01-13 | 2007-11-07 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| WO2006094235A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | Fused heterocyclic compounds and their use as sirtuin modulators |
| CA2609549A1 (en) * | 2005-05-25 | 2006-11-30 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| WO2007041643A1 (en) * | 2005-10-03 | 2007-04-12 | University Of Tennessee Research Foundation | Dietary calcium for reducing the production of reactive oxygen species |
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| US20100047177A1 (en) * | 2007-01-26 | 2010-02-25 | Washington University | Methods and compositions for treating neuropathies |
| WO2009035673A1 (en) * | 2007-09-12 | 2009-03-19 | Trustees Of Columbia University In The City Of Newyork | Compositions and methods for treating macular degeneration |
| ES2586459T3 (es) | 2008-05-01 | 2016-10-14 | Glaxosmithkline Llc | Quinolinas y análogos relacionados como moduladores de sirtuina |
| CA2729128C (en) | 2008-07-03 | 2016-05-31 | Sirtris Pharmaceuticals, Inc. | Benzimidazoles and related analogs as sirtuin modulators |
| MX2011003373A (es) | 2008-09-29 | 2011-06-09 | Sirtris Pharmaceuticals Inc | Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina. |
| MX2012004995A (es) | 2009-10-29 | 2012-10-03 | Sirtris Pharmaceuticals Inc | Piridinas biciclicas y analogos como moduladores de sirtuina. |
| US20110105990A1 (en) * | 2009-11-04 | 2011-05-05 | Silvestrini Thomas A | Zonal drug delivery device and method |
| US9125858B2 (en) * | 2009-11-30 | 2015-09-08 | Wilmore Labs L.L.C. | Compositions and methods relating to resveratrol |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| WO2012008549A1 (ja) | 2010-07-15 | 2012-01-19 | 武田薬品工業株式会社 | 複素環化合物 |
| US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
| WO2012149285A1 (en) * | 2011-04-28 | 2012-11-01 | Claire Mitchell | Method for treatment of macular degeneration by modulating p2y12 or p2x7 receptors |
| US20120276186A1 (en) | 2011-04-29 | 2012-11-01 | Ghebremeskel Alazar N | Sustained release latanoprost implant |
| JP5848042B2 (ja) | 2011-06-29 | 2016-01-27 | 株式会社ロッテ | 眼疲労抑制組成物及びそれを含む飲食品 |
| RU2631597C2 (ru) | 2011-07-15 | 2017-09-25 | Нусерт Сайенсиз, Инк. | Композиции и способы модулирования метаболических путей |
| WO2013033513A1 (en) | 2011-08-31 | 2013-03-07 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| US8916528B2 (en) | 2011-11-16 | 2014-12-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
| JP6356614B2 (ja) | 2012-02-17 | 2018-07-11 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | 薬剤のミトコンドリア輸送のためのナノ粒子 |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| JP5948139B2 (ja) * | 2012-05-11 | 2016-07-06 | ヒノキ新薬株式会社 | サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤 |
| US9877981B2 (en) | 2012-10-09 | 2018-01-30 | President And Fellows Of Harvard College | NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation |
| SG10201709195TA (en) | 2012-11-13 | 2017-12-28 | Nusirt Sciences Inc | Compositions and methods for increasing energy metabolism |
| EP2968306B1 (en) | 2013-03-15 | 2023-06-07 | Washington University | Administration of nicotinamide mononucleotide in the treatment of dry eye |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| KR20160119863A (ko) | 2014-02-27 | 2016-10-14 | 뉴서트 사이언시스, 인크. | 간 지방증의 감소 또는 예방을 위한 조성물 및 방법 |
| US10398663B2 (en) | 2014-03-14 | 2019-09-03 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| WO2016031869A1 (ja) * | 2014-08-28 | 2016-03-03 | 学校法人 慶應義塾 | スチルベン化合物を有効成分とする角結膜疾患又は老視の予防及び／又は治療のための医薬組成物 |
| JP6520019B2 (ja) * | 2014-08-28 | 2019-05-29 | 学校法人昭和大学 | 新規スチルベン誘導体 |
| JP2018100222A (ja) * | 2015-04-20 | 2018-06-28 | 学校法人慶應義塾 | 角膜損傷の治療剤、改善剤または予防剤 |
| WO2018052019A1 (ja) * | 2016-09-13 | 2018-03-22 | めぐみ 田中 | 視覚機能改善剤及び視覚機能の改善方法 |
| WO2018089797A1 (en) * | 2016-11-14 | 2018-05-17 | Mingwu Wang | Formulations for the treatment of ocular surface diseases and related methods |
| JP6986345B2 (ja) * | 2016-11-18 | 2021-12-22 | ロート製薬株式会社 | 経口組成物及びその製造方法 |
| ES2673942B1 (es) * | 2016-11-23 | 2019-04-09 | Consejo Superior Investigacion | Compuestos acilados para el tratamiento de patologias oculares |
| AU2017390276A1 (en) * | 2017-01-03 | 2019-06-27 | Vitrean, Inc. | Methods and devices for treating a retinal detachment |
| WO2019108875A1 (en) * | 2017-12-01 | 2019-06-06 | Elysium Health, Inc. | Methods and compositions for treating glaucoma |
| WO2020144753A1 (ja) | 2019-01-09 | 2020-07-16 | 公立大学法人大阪 | 神経変性疾患の予防又は治療薬 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383992A (en) * | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
| FR2543550B1 (fr) * | 1983-04-01 | 1985-08-09 | Cortial | Nouveaux derives de la tetrahydroxy-3', 4',5,7 flavone, leur methode de preparation et leur emploi therapeutique |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| MY106598A (en) * | 1988-08-31 | 1995-06-30 | Australian Commercial Res & Development Ltd | Compositions and methods for drug delivery and chromatography. |
| US5589483A (en) * | 1994-12-21 | 1996-12-31 | Geron Corporation | Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
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| US6399655B1 (en) * | 1998-12-22 | 2002-06-04 | Johns Hopkins University, School Of Medicine | Method for the prophylactic treatment of cataracts |
| US6573299B1 (en) * | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
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| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
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| US20060111318A1 (en) * | 2003-04-18 | 2006-05-25 | Advanced Medicine Research Institute | Agent for treating eye diseases |
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| US20050158376A1 (en) * | 2003-10-23 | 2005-07-21 | Sardi William F. | Dietary supplement and method of processing same |
| US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
| EP1723227A4 (en) * | 2004-02-10 | 2007-09-19 | Dartmouth College | NICOTINAMIDRIBOSIDE KINASE COMPOSITIONS AND METHOD FOR THEIR USE |
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| US20060084085A1 (en) * | 2004-06-16 | 2006-04-20 | Sinclair David A | Methods and compositions for modulating Bax-mediated apoptosis |
| US20060024385A1 (en) * | 2004-07-27 | 2006-02-02 | Pedersen Mark A | Metabolic capacity enhancing compositions and methods for use in a mammal |
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| JP2008528510A (ja) * | 2005-01-20 | 2008-07-31 | サートリス ファーマシューティカルズ， インコーポレイテッド | 紅潮および／または薬物誘発性体重増加を処置するためのサーチュイン活性化化合物の使用 |
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| DK1910384T3 (da) * | 2005-08-04 | 2012-12-17 | Sirtris Pharmaceuticals Inc | Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser |
| US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| CN101360421B (zh) * | 2005-11-18 | 2014-06-18 | 康乃尔研究基金会有限公司 | 烟酰核苷组合物及其使用方法 |
| US20100168084A1 (en) * | 2008-05-08 | 2010-07-01 | Huber L Julie | Therapeutic compounds and related methods of use |
| BRPI0922435A2 (pt) * | 2008-12-19 | 2018-09-11 | Sirtris Pharmaceuticals Inc | "composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso." |
-
2005
- 2005-10-28 US US11/374,278 patent/US20070014833A1/en not_active Abandoned
-
2006
- 2006-03-30 WO PCT/US2006/011930 patent/WO2006105403A2/en not_active Ceased
- 2006-03-30 EP EP06749032A patent/EP1863462A2/en not_active Ceased
- 2006-03-30 AU AU2006230478A patent/AU2006230478B2/en not_active Ceased
- 2006-03-30 CA CA002603009A patent/CA2603009A1/en not_active Abandoned
- 2006-03-30 JP JP2008504422A patent/JP2008538215A/ja active Pending
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