JP2008538215A - サーチュイン活性化剤による眼障害の処置 - Google Patents

サーチュイン活性化剤による眼障害の処置 Download PDF

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Publication number
JP2008538215A
JP2008538215A JP2008504422A JP2008504422A JP2008538215A JP 2008538215 A JP2008538215 A JP 2008538215A JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008504422 A JP2008504422 A JP 2008504422A JP 2008538215 A JP2008538215 A JP 2008538215A
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formula
compound
further embodiment
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sirtuin activator
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JP2008538215A5 (https=
Inventor
クリストファー アール． ウエストファール，
ミシェル ディップ，
マイケル ミルバーン，
Original Assignee
サートリス ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2008538215A publication Critical patent/JP2008538215A/ja
Publication of JP2008538215A5 publication Critical patent/JP2008538215A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
JP2008504422A 2005-03-30 2006-03-30 サーチュイン活性化剤による眼障害の処置 Pending JP2008538215A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66717905P 2005-03-30 2005-03-30
US68425205P 2005-05-25 2005-05-25
US11/374,278 US20070014833A1 (en) 2005-03-30 2005-10-28 Treatment of eye disorders with sirtuin modulators
PCT/US2006/011930 WO2006105403A2 (en) 2005-03-30 2006-03-30 Treatment of eye disorders with sirtuin modulators

Publications (2)

Publication Number Publication Date
JP2008538215A true JP2008538215A (ja) 2008-10-16
JP2008538215A5 JP2008538215A5 (https=) 2009-04-09

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JP2008504422A Pending JP2008538215A (ja) 2005-03-30 2006-03-30 サーチュイン活性化剤による眼障害の処置

Country Status (6)

Country Link
US (1) US20070014833A1 (https=)
EP (1) EP1863462A2 (https=)
JP (1) JP2008538215A (https=)
AU (1) AU2006230478B2 (https=)
CA (1) CA2603009A1 (https=)
WO (1) WO2006105403A2 (https=)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008542296A (ja) * 2005-05-25 2008-11-27 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン活性化剤による眼障害の処置
JP2013237618A (ja) * 2012-05-11 2013-11-28 Hinoki Shinyaku Kk サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤
KR20140048212A (ko) 2011-06-29 2014-04-23 가부시키가이샤 롯데 눈 피로 억제 조성물 및 그것을 함유하는 음식품
JP2015187141A (ja) * 2005-07-01 2015-10-29 プレジデント アンド フェローズ オブ ハーバード カレッジ 肥満及びインシュリン耐性障害を治療又は予防するための組成物
JP2016050172A (ja) * 2014-08-28 2016-04-11 学校法人昭和大学 新規スチルベン誘導体
WO2016171152A1 (ja) * 2015-04-20 2016-10-27 学校法人 慶應義塾 角膜障害の治療剤、改善剤または予防剤
JPWO2016031869A1 (ja) * 2014-08-28 2017-06-15 学校法人慶應義塾 スチルベン化合物を有効成分とする角結膜疾患又は老視の予防及び／又は治療のための医薬組成物
WO2018052019A1 (ja) * 2016-09-13 2018-03-22 めぐみ 田中 視覚機能改善剤及び視覚機能の改善方法
JP2018078860A (ja) * 2016-11-18 2018-05-24 学校法人大阪医科薬科大学 経口組成物
JP2019534335A (ja) * 2016-11-14 2019-11-28 ミングゥ・ワン 眼表面疾患の治療のための製剤および関連方法

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WO2014059034A2 (en) 2012-10-09 2014-04-17 President And Fellows Of Harvard College Nad biosynthesis and precursors for the treatment and prevention of cancer and proliferation
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CN105228627B (zh) 2013-03-15 2018-07-13 纽斯尔特科学公司 亮氨酸和烟酸降低脂质水平
PL2968306T3 (pl) 2013-03-15 2024-01-29 Washington University Podawanie mononukleotydu nikotynamidu do leczenia zespołu suchego oka
EP3110507B1 (en) 2014-02-27 2020-11-18 NuSirt Sciences, Inc. Compositions and methods for the reduction or prevention of hepatic steatosis
WO2015138992A1 (en) 2014-03-14 2015-09-17 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
ES2673942B1 (es) * 2016-11-23 2019-04-09 Consejo Superior Investigacion Compuestos acilados para el tratamiento de patologias oculares
AU2017390276A1 (en) * 2017-01-03 2019-06-27 Vitrean, Inc. Methods and devices for treating a retinal detachment
WO2019108875A1 (en) * 2017-12-01 2019-06-06 Elysium Health, Inc. Methods and compositions for treating glaucoma
WO2020144753A1 (ja) 2019-01-09 2020-07-16 公立大学法人大阪 神経変性疾患の予防又は治療薬

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008542296A (ja) * 2005-05-25 2008-11-27 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン活性化剤による眼障害の処置
JP2015187141A (ja) * 2005-07-01 2015-10-29 プレジデント アンド フェローズ オブ ハーバード カレッジ 肥満及びインシュリン耐性障害を治療又は予防するための組成物
KR20140048212A (ko) 2011-06-29 2014-04-23 가부시키가이샤 롯데 눈 피로 억제 조성물 및 그것을 함유하는 음식품
JP2013237618A (ja) * 2012-05-11 2013-11-28 Hinoki Shinyaku Kk サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤
JP2016050172A (ja) * 2014-08-28 2016-04-11 学校法人昭和大学 新規スチルベン誘導体
JPWO2016031869A1 (ja) * 2014-08-28 2017-06-15 学校法人慶應義塾 スチルベン化合物を有効成分とする角結膜疾患又は老視の予防及び／又は治療のための医薬組成物
WO2016171152A1 (ja) * 2015-04-20 2016-10-27 学校法人 慶應義塾 角膜障害の治療剤、改善剤または予防剤
WO2018052019A1 (ja) * 2016-09-13 2018-03-22 めぐみ 田中 視覚機能改善剤及び視覚機能の改善方法
JPWO2018052019A1 (ja) * 2016-09-13 2019-06-24 めぐみ 田中 視覚機能改善剤及び視覚機能の改善方法
US10898738B2 (en) 2016-09-13 2021-01-26 Megumi Tanaka Visual function printing agent, and method for improving visual functions
JP2019534335A (ja) * 2016-11-14 2019-11-28 ミングゥ・ワン 眼表面疾患の治療のための製剤および関連方法
JP2018078860A (ja) * 2016-11-18 2018-05-24 学校法人大阪医科薬科大学 経口組成物

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Publication number Publication date
WO2006105403A2 (en) 2006-10-05
WO2006105403A3 (en) 2007-03-15
AU2006230478B2 (en) 2011-12-22
US20070014833A1 (en) 2007-01-18
AU2006230478A1 (en) 2006-10-05
CA2603009A1 (en) 2006-10-05
EP1863462A2 (en) 2007-12-12

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