JP2008537874A5 - - Google Patents

Info

Publication number

JP2008537874A5

JP2008537874A5 JP2007533727A JP2007533727A JP2008537874A5 JP 2008537874 A5 JP2008537874 A5 JP 2008537874A5 JP 2007533727 A JP2007533727 A JP 2007533727A JP 2007533727 A JP2007533727 A JP 2007533727A JP 2008537874 A5 JP2008537874 A5 JP 2008537874A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

polynucleotide

cell line

rage

Prior art date

2005-09-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229920001184 polypeptide Polymers 0.000 claims 22
• 102000004196 processed proteins & peptides Human genes 0.000 claims 22
• 108090000765 processed proteins & peptides Proteins 0.000 claims 22
• 102000040430 polynucleotide Human genes 0.000 claims 6
• 108091033319 polynucleotide Proteins 0.000 claims 6
• 239000002157 polynucleotide Substances 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 208000024891 symptom Diseases 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 4
• 108010005094 Advanced Glycation End Products Proteins 0.000 claims 2
• 102100029599 Advanced glycosylation end product-specific receptor Human genes 0.000 claims 2
• 101001061840 Homo sapiens Advanced glycosylation end product-specific receptor Proteins 0.000 claims 2
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 239000000825 pharmaceutical preparation Substances 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 229930183010 Amphotericin Natural products 0.000 claims 1
• QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 claims 1
• 206010003210 Arteriosclerosis Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 claims 1
• 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 208000025966 Neurological disease Diseases 0.000 claims 1
• 206010053613 Type IV hypersensitivity reaction Diseases 0.000 claims 1
• 229940009444 amphotericin Drugs 0.000 claims 1
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 1
• 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 206010009887 colitis Diseases 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 208000026278 immune system disease Diseases 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 230000003211 malignant effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 239000007800 oxidant agent Substances 0.000 claims 1
• 230000001590 oxidative effect Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 230000004614 tumor growth Effects 0.000 claims 1
• 230000005951 type IV hypersensitivity Effects 0.000 claims 1
• 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 1