JP2008536865A5 - - Google Patents
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- Publication number
- JP2008536865A5 JP2008536865A5 JP2008506765A JP2008506765A JP2008536865A5 JP 2008536865 A5 JP2008536865 A5 JP 2008536865A5 JP 2008506765 A JP2008506765 A JP 2008506765A JP 2008506765 A JP2008506765 A JP 2008506765A JP 2008536865 A5 JP2008536865 A5 JP 2008536865A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- egfr
- pharmaceutical
- analog
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 23
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims 18
- 229930003448 Vitamin K Natural products 0.000 claims 17
- 235000019168 vitamin K Nutrition 0.000 claims 17
- 239000011712 vitamin K Substances 0.000 claims 17
- 150000003721 vitamin K derivatives Chemical class 0.000 claims 17
- 229940046010 vitamin k Drugs 0.000 claims 17
- 102000001301 EGF receptor Human genes 0.000 claims 16
- 108060006698 EGF receptor Proteins 0.000 claims 16
- 235000012711 vitamin K3 Nutrition 0.000 claims 9
- 239000011652 vitamin K3 Substances 0.000 claims 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 229940122907 Phosphatase inhibitor Drugs 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 208000010201 Exanthema Diseases 0.000 claims 6
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 claims 6
- 201000005884 exanthem Diseases 0.000 claims 6
- 235000019175 phylloquinone Nutrition 0.000 claims 6
- 239000011772 phylloquinone Substances 0.000 claims 6
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims 6
- 229960001898 phytomenadione Drugs 0.000 claims 6
- 206010037844 rash Diseases 0.000 claims 6
- 238000011282 treatment Methods 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 4
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 4
- 206010028124 Mucosal ulceration Diseases 0.000 claims 4
- 206010040943 Skin Ulcer Diseases 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 238000011123 anti-EGFR therapy Methods 0.000 claims 4
- 230000030609 dephosphorylation Effects 0.000 claims 4
- 238000006209 dephosphorylation reaction Methods 0.000 claims 4
- 229940116977 epidermal growth factor Drugs 0.000 claims 4
- 208000025865 Ulcer Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 238000011200 topical administration Methods 0.000 claims 3
- 231100000397 ulcer Toxicity 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 229960005395 cetuximab Drugs 0.000 claims 2
- 208000014834 chemotherapy-induced oral mucositis Diseases 0.000 claims 2
- 229940121647 egfr inhibitor Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 231100000046 skin rash Toxicity 0.000 claims 2
- 208000003265 stomatitis Diseases 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 108010048999 Transcription Factor 3 Proteins 0.000 claims 1
- 102100038313 Transcription factor E2-alpha Human genes 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical group C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67156305P | 2005-04-15 | 2005-04-15 | |
| PCT/US2006/014158 WO2006113479A2 (en) | 2005-04-15 | 2006-04-12 | Vitamin k for prevention and treatment of skin rash secondary to anti-egfr therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012196249A Division JP5620443B2 (ja) | 2005-04-15 | 2012-09-06 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536865A JP2008536865A (ja) | 2008-09-11 |
| JP2008536865A5 true JP2008536865A5 (enExample) | 2009-05-28 |
Family
ID=37115750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506765A Withdrawn JP2008536865A (ja) | 2005-04-15 | 2006-04-12 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
| JP2012196249A Expired - Fee Related JP5620443B2 (ja) | 2005-04-15 | 2012-09-06 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012196249A Expired - Fee Related JP5620443B2 (ja) | 2005-04-15 | 2012-09-06 | 抗ｅｇｆｒ療法に二次的な皮疹の予防および処置のためのビタミンｋ |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7745494B2 (enExample) |
| EP (3) | EP1871353B1 (enExample) |
| JP (2) | JP2008536865A (enExample) |
| KR (1) | KR101332869B1 (enExample) |
| AT (1) | ATE492275T1 (enExample) |
| AU (1) | AU2006236633B2 (enExample) |
| CA (2) | CA2851079A1 (enExample) |
| CY (1) | CY1111786T1 (enExample) |
| DE (1) | DE602006019074D1 (enExample) |
| DK (1) | DK1871353T3 (enExample) |
| ES (1) | ES2358528T3 (enExample) |
| PT (1) | PT1871353E (enExample) |
| WO (1) | WO2006113479A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| CA2851079A1 (en) | 2005-04-15 | 2006-10-26 | Albert Einstein College Of Medicine Of Yeshiva University | Vitamin k for prevention and treatment of skin rash secondary to anti-egfr therapy |
| EP2043685B1 (en) * | 2006-07-03 | 2015-12-23 | Genmab A/S | Prevention of rash in patients undergoing anti-egfr therapy |
| US8815953B2 (en) * | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
| US20100010100A1 (en) * | 2008-07-09 | 2010-01-14 | Hinman Andrew W | Dermatological compositions with anti-aging and skin even-toning properties |
| US20100029784A1 (en) * | 2008-07-30 | 2010-02-04 | Hinman Andrew W | Naphthoquinone compositions with anti-aging, anti-inflammatory and skin even-toning properties |
| JP5765634B2 (ja) | 2008-10-21 | 2015-08-19 | スレッシュホールド ファーマシューティカルズ， インコーポレイテッド | 低酸素活性化型プロドラッグを用いるがんの処置 |
| CN102458473A (zh) * | 2009-06-26 | 2012-05-16 | 英属开曼群岛商安盛开发药物股份有限公司 | 治疗或减缓粘膜皮肤或眼睛毒性的方法 |
| ITPD20100090A1 (it) * | 2010-03-22 | 2011-09-23 | Sanitas Farmaceutici S R L | Formulazione topica per il trattamento di eruzioni cutanee, in particolare conseguenti a trattamenti con farmaci anti egfr |
| WO2012111187A1 (ja) | 2011-02-14 | 2012-08-23 | 株式会社Ｊ－オイルミルズ | 皮膚コラーゲン産生促進剤 |
| EP2712613B1 (en) * | 2012-09-28 | 2017-02-08 | Pharmadab d.o.o. | Vitamin K1 and uses thereof |
| US9421297B2 (en) | 2014-04-02 | 2016-08-23 | Adhezion Biomedical, Llc | Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides |
| WO2016120341A2 (en) | 2015-01-27 | 2016-08-04 | Vitak B.V. | Epidermal skin health |
| CN111601617A (zh) | 2017-12-13 | 2020-08-28 | 上海岸阔医药科技有限公司 | 一种用于预防或治疗与egfr 被抑制相关疾病的方法 |
| JP7520366B2 (ja) | 2018-04-16 | 2024-07-23 | オンクオリティー ファーマシューティカルズ チャイナ リミテッド | 腫瘍療法の副作用の予防または治療方法 |
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-
2006
- 2006-04-12 CA CA2851079A patent/CA2851079A1/en not_active Abandoned
- 2006-04-12 EP EP06750246A patent/EP1871353B1/en active Active
- 2006-04-12 KR KR1020077026480A patent/KR101332869B1/ko not_active Expired - Fee Related
- 2006-04-12 ES ES06750246T patent/ES2358528T3/es active Active
- 2006-04-12 AU AU2006236633A patent/AU2006236633B2/en not_active Ceased
- 2006-04-12 EP EP10195772.8A patent/EP2305224B1/en active Active
- 2006-04-12 DK DK06750246.8T patent/DK1871353T3/da active
- 2006-04-12 AT AT06750246T patent/ATE492275T1/de active
- 2006-04-12 WO PCT/US2006/014158 patent/WO2006113479A2/en not_active Ceased
- 2006-04-12 EP EP11189225A patent/EP2494965A3/en not_active Withdrawn
- 2006-04-12 US US11/886,803 patent/US7745494B2/en not_active Expired - Fee Related
- 2006-04-12 DE DE602006019074T patent/DE602006019074D1/de active Active
- 2006-04-12 PT PT06750246T patent/PT1871353E/pt unknown
- 2006-04-12 JP JP2008506765A patent/JP2008536865A/ja not_active Withdrawn
- 2006-04-12 CA CA2603785A patent/CA2603785C/en not_active Expired - Fee Related
-
2009
- 2009-05-14 US US12/465,980 patent/US20090239952A1/en not_active Abandoned
-
2010
- 2010-05-26 US US12/788,015 patent/US8283382B2/en not_active Expired - Fee Related
-
2011
- 2011-03-16 CY CY20111100295T patent/CY1111786T1/el unknown
-
2012
- 2012-09-06 JP JP2012196249A patent/JP5620443B2/ja not_active Expired - Fee Related
- 2012-09-20 US US13/623,625 patent/US20130225690A1/en not_active Abandoned
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