JP2008536479A5 - - Google Patents

Info

Publication number

JP2008536479A5

JP2008536479A5 JP2007556197A JP2007556197A JP2008536479A5 JP 2008536479 A5 JP2008536479 A5 JP 2008536479A5 JP 2007556197 A JP2007556197 A JP 2007556197A JP 2007556197 A JP2007556197 A JP 2007556197A JP 2008536479 A5 JP2008536479 A5 JP 2008536479A5

Authority

JP

Japan

Prior art keywords

disintegrin domain

disintegrin

recombinant

sequence

chimeric

Prior art date

2006-02-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 101800001224 Disintegrin Proteins 0.000 claims description 32
• 210000004899 c-terminal region Anatomy 0.000 claims description 6
• 108010044426 integrins Proteins 0.000 claims 9
• 102000006495 integrins Human genes 0.000 claims 9
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 6
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 6
• 102000002933 Thioredoxin Human genes 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 108060008226 thioredoxin Proteins 0.000 claims 4
• 229940094937 thioredoxin Drugs 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• XLBBKEHLEPNMMF-SSUNCQRMSA-N 129038-42-2 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)[C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCC(O)=O)C1=CC=CC=C1 XLBBKEHLEPNMMF-SSUNCQRMSA-N 0.000 claims 1
• 102100022337 Integrin alpha-V Human genes 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• 108010022425 Platelet Glycoprotein GPIIb-IIIa Complex Proteins 0.000 claims 1
• 108010048673 Vitronectin Receptors Proteins 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 230000021164 cell adhesion Effects 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 108010025752 echistatin Proteins 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
• 230000001131 transforming effect Effects 0.000 claims 1
• 241000271045 Agkistrodon contortrix contortrix Species 0.000 description 2
• 150000001413 amino acids Chemical class 0.000 description 2
• 108020004999 messenger RNA Proteins 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 239000003998 snake venom Substances 0.000 description 2
• 108010057810 vicrostatin Proteins 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
• 108700021041 Disintegrin Proteins 0.000 description 1
• 102000005741 Metalloproteases Human genes 0.000 description 1
• 108010006035 Metalloproteases Proteins 0.000 description 1
• 108700026244 Open Reading Frames Proteins 0.000 description 1
• 238000010353 genetic engineering Methods 0.000 description 1
• 210000004907 gland Anatomy 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• 230000002797 proteolythic effect Effects 0.000 description 1
• 239000002435 venom Substances 0.000 description 1
• 210000001048 venom Anatomy 0.000 description 1
• 231100000611 venom Toxicity 0.000 description 1