JP2008535830A5 - - Google Patents

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Publication number
JP2008535830A5
JP2008535830A5 JP2008504337A JP2008504337A JP2008535830A5 JP 2008535830 A5 JP2008535830 A5 JP 2008535830A5 JP 2008504337 A JP2008504337 A JP 2008504337A JP 2008504337 A JP2008504337 A JP 2008504337A JP 2008535830 A5 JP2008535830 A5 JP 2008535830A5
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JP
Japan
Prior art keywords
compound
methyl
cancer
chk1
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008504337A
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English (en)
Japanese (ja)
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JP2008535830A (ja
JP5117374B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/011584 external-priority patent/WO2006105262A1/en
Publication of JP2008535830A publication Critical patent/JP2008535830A/ja
Publication of JP2008535830A5 publication Critical patent/JP2008535830A5/ja
Application granted granted Critical
Publication of JP5117374B2 publication Critical patent/JP5117374B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2008504337A 2005-03-29 2006-03-29 Chk1阻害に有用なヘテロアリール尿素誘導体 Expired - Fee Related JP5117374B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66602605P 2005-03-29 2005-03-29
US60/666,026 2005-03-29
PCT/US2006/011584 WO2006105262A1 (en) 2005-03-29 2006-03-29 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009122107A Division JP2009227682A (ja) 2005-03-29 2009-05-20 Chk1阻害に有用なヘテロアリール尿素誘導体

Publications (3)

Publication Number Publication Date
JP2008535830A JP2008535830A (ja) 2008-09-04
JP2008535830A5 true JP2008535830A5 (https=) 2009-07-09
JP5117374B2 JP5117374B2 (ja) 2013-01-16

Family

ID=36677174

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008504337A Expired - Fee Related JP5117374B2 (ja) 2005-03-29 2006-03-29 Chk1阻害に有用なヘテロアリール尿素誘導体
JP2009122107A Pending JP2009227682A (ja) 2005-03-29 2009-05-20 Chk1阻害に有用なヘテロアリール尿素誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009122107A Pending JP2009227682A (ja) 2005-03-29 2009-05-20 Chk1阻害に有用なヘテロアリール尿素誘導体

Country Status (31)

Country Link
US (1) US8093244B2 (https=)
EP (2) EP1869020B1 (https=)
JP (2) JP5117374B2 (https=)
KR (2) KR100912998B1 (https=)
CN (2) CN101151259B (https=)
AR (1) AR056645A1 (https=)
AT (1) ATE490248T1 (https=)
AU (1) AU2006230337B2 (https=)
BR (1) BRPI0609667A2 (https=)
CA (1) CA2602199C (https=)
CR (1) CR9395A (https=)
CY (1) CY1111240T1 (https=)
DE (1) DE602006018590D1 (https=)
DK (1) DK1869020T3 (https=)
EA (1) EA011287B1 (https=)
ES (1) ES2356068T3 (https=)
HR (1) HRP20100678T1 (https=)
IL (1) IL185481A0 (https=)
MA (1) MA29439B1 (https=)
MX (1) MX2007012116A (https=)
NO (1) NO20074944L (https=)
NZ (1) NZ561458A (https=)
PL (1) PL1869020T3 (https=)
PT (1) PT1869020E (https=)
RS (1) RS51616B (https=)
SI (1) SI1869020T1 (https=)
TN (1) TNSN07369A1 (https=)
TW (1) TWI375559B (https=)
UA (1) UA92164C2 (https=)
WO (1) WO2006105262A1 (https=)
ZA (1) ZA200707715B (https=)

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GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
CN105764501A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群治疗效益的组合物
LT3157566T (lt) 2014-06-17 2019-08-12 Vertex Pharmaceuticals Incorporated Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
HK1258570A1 (zh) 2015-09-30 2019-11-15 Vertex Pharmaceuticals Inc. 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法
HRP20220351T1 (hr) 2016-02-04 2022-05-13 Pharmaengine, Inc. 3,5-disupstituirani pirazoli korisni kao inhibitori kinaze 1 kontrolne točke (chk1), i njihove pripreme i primjene
ES3057783T3 (en) 2016-03-15 2026-03-04 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
US20200108074A1 (en) * 2017-03-31 2020-04-09 Seattle Genetics, Inc. Combinations of chk1- and wee1- inhibitors
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
CN112457306A (zh) 2019-09-06 2021-03-09 上海瑛派药业有限公司 3,5-二取代吡唑化合物作为激酶抑制剂及其应用
US12404332B2 (en) * 2020-03-13 2025-09-02 Research Development Foundation Methods for diagnosing and treating cancers

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US6174993B1 (en) 1997-05-21 2001-01-16 The Children's Medical Center Corp. Short peptides which selectively modulate the activity of serine/threonine kinases
US6218109B1 (en) 1997-09-05 2001-04-17 Baylor College Of Medicine Mammalian checkpoint genes and proteins
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AU2001243226A1 (en) 2000-02-25 2001-09-03 The Regents Of The University Of California Scytonemin and methods of using thereof
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