EA011287B1 - Производные гетероарилмочевины, пригодные для ингибирования chk1 - Google Patents

Info

Publication number

EA011287B1

EA011287B1 EA200702094A EA200702094A EA011287B1 EA 011287 B1 EA011287 B1 EA 011287B1 EA 200702094 A EA200702094 A EA 200702094A EA 200702094 A EA200702094 A EA 200702094A EA 011287 B1 EA011287 B1 EA 011287B1

Authority

EA

Eurasian Patent Office

Prior art keywords

urea

ylmethoxy

phenyl

methylpyrazin

chloro

Prior art date

2005-03-29

Links

• Espacenet
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• -1 Heteroaryl urea derivatives Chemical class 0.000 title claims description 86
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• 101150050673 CHK1 gene Proteins 0.000 title 1
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• 238000011282 treatment Methods 0.000 claims abstract description 40
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 78
• 150000003839 salts Chemical class 0.000 claims description 30
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims description 12
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• DZFHIBKVLIUPKD-UHFFFAOYSA-N 1-(5-cyanopyrazin-2-yl)-3-[5-methyl-2-(morpholin-2-ylmethoxy)phenyl]urea Chemical compound C=1N=C(C#N)C=NC=1NC(=O)NC1=CC(C)=CC=C1OCC1CNCCO1 DZFHIBKVLIUPKD-UHFFFAOYSA-N 0.000 claims description 3
• ZNLXMIFDDUGZFX-UHFFFAOYSA-N 1-(5-cyanopyrazin-2-yl)-3-[5-methyl-2-[(4-methylmorpholin-2-yl)methoxy]phenyl]urea Chemical compound C1N(C)CCOC1COC1=CC=C(C)C=C1NC(=O)NC1=CN=C(C#N)C=N1 ZNLXMIFDDUGZFX-UHFFFAOYSA-N 0.000 claims description 3
• NAIANIQLNWNLLT-UHFFFAOYSA-N 1-[2-[(1,4-dimethylpiperazin-2-yl)methoxy]-5-methylphenyl]-3-(5-methylpyrazin-2-yl)urea Chemical compound C1N(C)CCN(C)C1COC1=CC=C(C)C=C1NC(=O)NC1=CN=C(C)C=N1 NAIANIQLNWNLLT-UHFFFAOYSA-N 0.000 claims description 3
• ZVHPDSOOZVPXMU-UHFFFAOYSA-N 1-[4,5-dimethyl-2-(morpholin-2-ylmethoxy)phenyl]-3-(5-methylpyrazin-2-yl)urea Chemical compound C1=NC(C)=CN=C1NC(=O)NC1=CC(C)=C(C)C=C1OCC1OCCNC1 ZVHPDSOOZVPXMU-UHFFFAOYSA-N 0.000 claims description 3
• LTMBULZIIXFVGE-UHFFFAOYSA-N 1-[5-chloro-2-(1,4-oxazepan-2-ylmethoxy)phenyl]-3-(5-methylpyrazin-2-yl)urea Chemical compound C1=NC(C)=CN=C1NC(=O)NC1=CC(Cl)=CC=C1OCC1OCCCNC1 LTMBULZIIXFVGE-UHFFFAOYSA-N 0.000 claims description 3
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• NVXNVZCYLPNQGP-UHFFFAOYSA-N 1-[5-bromo-2-(1,4-oxazepan-2-ylmethoxy)phenyl]-3-(5-methylpyrazin-2-yl)urea Chemical compound C1=NC(C)=CN=C1NC(=O)NC1=CC(Br)=CC=C1OCC1OCCCNC1 NVXNVZCYLPNQGP-UHFFFAOYSA-N 0.000 claims description 2
• WMWHLOFEZHABBA-UHFFFAOYSA-N 1-[5-bromo-2-[(4-methyl-1,4-oxazepan-2-yl)methoxy]phenyl]-3-(5-methylpyrazin-2-yl)urea Chemical compound C1N(C)CCCOC1COC1=CC=C(Br)C=C1NC(=O)NC1=CN=C(C)C=N1 WMWHLOFEZHABBA-UHFFFAOYSA-N 0.000 claims description 2
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