JP2008535496A5 - - Google Patents
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- JP2008535496A5 JP2008535496A5 JP2008505634A JP2008505634A JP2008535496A5 JP 2008535496 A5 JP2008535496 A5 JP 2008535496A5 JP 2008505634 A JP2008505634 A JP 2008505634A JP 2008505634 A JP2008505634 A JP 2008505634A JP 2008535496 A5 JP2008535496 A5 JP 2008535496A5
- Authority
- JP
- Japan
- Prior art keywords
- rnai
- subject
- inducing entity
- body weight
- entity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091030071 RNAI Proteins 0.000 claims 22
- 230000009368 gene silencing by RNA Effects 0.000 claims 22
- 230000001939 inductive effect Effects 0.000 claims 21
- 230000037396 body weight Effects 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 229920006317 cationic polymer Polymers 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66994205P | 2005-04-08 | 2005-04-08 | |
| PCT/US2006/013374 WO2006110688A2 (en) | 2005-04-08 | 2006-04-07 | Rnai therapeutic for respiratory virus infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535496A JP2008535496A (ja) | 2008-09-04 |
| JP2008535496A5 true JP2008535496A5 (enExample) | 2009-05-28 |
Family
ID=37087607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008505634A Pending JP2008535496A (ja) | 2005-04-08 | 2006-04-07 | 呼吸器ウィルス感染用RNAi治療因子 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100254945A1 (enExample) |
| EP (1) | EP1874802A2 (enExample) |
| JP (1) | JP2008535496A (enExample) |
| KR (1) | KR20070118703A (enExample) |
| CN (1) | CN101184839A (enExample) |
| AU (1) | AU2006235364A1 (enExample) |
| CA (1) | CA2603842A1 (enExample) |
| NO (1) | NO20075655L (enExample) |
| NZ (1) | NZ563845A (enExample) |
| WO (1) | WO2006110688A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006085987A2 (en) | 2004-07-09 | 2006-08-17 | University Of Iowa Research Foundation | Rna interference in respiratory epitheial cells |
| CA2602797A1 (en) * | 2005-03-31 | 2007-02-15 | Ronen Kahana | Creating poultry and other animals resistant to viral disease |
| EP2125024B1 (en) | 2007-03-23 | 2013-02-13 | TO-BBB Holding B.V. | Targeted intracellular delivery of antiviral agents |
| EP2146575A4 (en) * | 2007-04-12 | 2010-11-24 | Alnylam Pharmaceuticals Inc | INFLUENZA POLYNUCLEOTIDES, EXPRESSION CONSTRUCTS, COMPOSITIONS AND METHOD FOR THEIR USE |
| JP2010527914A (ja) * | 2007-04-26 | 2010-08-19 | クォーク ファーマシューティカルズ インコーポレーティッド | 呼吸器系への抑制性核酸分子の治療的送達 |
| AU2008251037A1 (en) * | 2007-05-15 | 2008-11-20 | Johnson & Johnson Research Pty Limited | Suppression of viruses involved in respiratory infection or disease |
| EP2527445A3 (en) * | 2007-05-16 | 2013-02-20 | MAT Malta Advanced Technologies Limited | Treatment and prevention of influenza |
| US20100273156A1 (en) * | 2007-05-31 | 2010-10-28 | Becton, Dickinson And Company | Sequences and methods for detecting influenza a and influenza b virus |
| KR101605932B1 (ko) | 2009-12-18 | 2016-03-24 | 노파르티스 아게 | Hsf1-관련 질환을 치료하기 위한 유기 조성물 |
| EP2631291B1 (en) | 2010-10-22 | 2019-05-15 | OliX Pharmaceuticals, Inc. | Nucleic acid molecules inducing rna interference, and uses thereof |
| KR20140027211A (ko) | 2011-04-04 | 2014-03-06 | 유니버시티 오브 아이오와 리써치 파운데이션 | 백신 면역원성의 개선 방법 |
| US9328347B2 (en) | 2011-07-18 | 2016-05-03 | Oregon Health & Science University | siRNA useful in the treatment of flavivirus infection |
| CN103930547A (zh) | 2011-09-02 | 2014-07-16 | 诺华股份有限公司 | 用于治疗hsf1相关疾病的有机组合物 |
| WO2013103434A1 (en) * | 2011-10-19 | 2013-07-11 | Harrisvaccines, Inc. | Methods and compositions to protect aquatic invertebrates from disease |
| KR101567576B1 (ko) * | 2012-05-22 | 2015-11-10 | 올릭스 주식회사 | 세포 내 관통능을 가지고 rna 간섭을 유도하는 핵산 분자 및 그 용도 |
| CN103966212A (zh) * | 2013-02-06 | 2014-08-06 | 霍晋 | A型流感病毒NP基因有干扰作用的siRNA序列的设计及应用 |
| WO2014138792A1 (en) * | 2013-03-14 | 2014-09-18 | Commonwealth Scientific And Industrial Research Organisation | Double-stranded rna |
| WO2017085550A1 (en) | 2015-11-16 | 2017-05-26 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| CN108779464B (zh) | 2016-02-02 | 2022-05-17 | 奥利克斯医药有限公司 | 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病 |
| US10358648B2 (en) | 2016-02-02 | 2019-07-23 | Olix Pharmaceuticals, Inc. | Treatment of atopic dermatitis and asthma using RNA complexes that target IL4Rα, TRPA1, or F2RL1 |
| US11339392B2 (en) | 2016-03-02 | 2022-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Pan-genotypic agents against influenza virus and methods of using the same |
| EP3423107A4 (en) * | 2016-03-02 | 2020-01-15 | The Board of Trustees of the Leland Stanford Junior University | PAN-GENOTYPICAL AGENTS AGAINST INFLUENZA-B VIRUS AND METHOD FOR USE THEREOF |
| WO2021201996A1 (en) * | 2020-02-14 | 2021-10-07 | The Board Of Trustees Of The Leland Stanford Junior University | Pan-genotypic agents against respiratory viruses and methods of using the same |
| KR102339886B1 (ko) | 2016-04-11 | 2021-12-17 | 올릭스 주식회사 | 연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법 |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| WO2018146557A2 (en) | 2017-02-10 | 2018-08-16 | Dong Ki Lee | Long double-stranded rna for rna interference |
| US11952631B2 (en) * | 2017-10-09 | 2024-04-09 | Medizinische Hochschule Hannover | Diagnostics and therapy for human respiratory syncytial virus |
| US11739350B2 (en) | 2018-04-10 | 2023-08-29 | Ottawa Hospital Research Institute | MicroRNA-based compositions and methods used in disease treatment |
| US11702709B2 (en) * | 2021-02-09 | 2023-07-18 | Pathogendx, Inc. | Combinatorial microarray assay for clade variant detection |
| CN115120608A (zh) * | 2021-03-26 | 2022-09-30 | 圣诺生物医药技术(苏州)有限公司 | 一种siRNA药物、药物组合物、siRNA-小分子药物偶联物及其应用 |
| EP4562157A1 (en) * | 2022-07-28 | 2025-06-04 | New York University | Targeting long non-coding rna chromr in interferon-mediated inflammation in humans |
| EP4527927A1 (en) | 2023-09-22 | 2025-03-26 | Medizinische Hochschule Hannover | Oligonucleotide-based strategies to combat respiratory viruses |
| CN118800477B (zh) * | 2024-07-11 | 2025-05-02 | 中国人民解放军军事科学院军事医学研究院 | 禽源性流感病毒溢出风险评估方法、设备、介质及产品 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US4876187A (en) * | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5573907A (en) | 1990-01-26 | 1996-11-12 | Abbott Laboratories | Detecting and amplifying target nucleic acids using exonucleolytic activity |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995014106A2 (en) * | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| ATE247716T1 (de) | 1994-02-07 | 2003-09-15 | Beckman Coulter Inc | Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse |
| JP3898228B2 (ja) * | 1996-04-12 | 2007-03-28 | ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク | 検出プローブ、キット及びアッセイ |
| US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| US20030087851A1 (en) * | 1999-01-20 | 2003-05-08 | Biozak, Inc. | Pharmaceutical composition for treating or preventing influenza, and novel oligonucleotide |
| US6277607B1 (en) * | 1999-05-24 | 2001-08-21 | Sanjay Tyagi | High specificity primers, amplification methods and kits |
| EP1081496A1 (en) * | 1999-08-31 | 2001-03-07 | Becton, Dickinson and Company | Flow-through assay for visually detecting the presence of influenza A and B |
| US20040137471A1 (en) * | 2002-09-18 | 2004-07-15 | Timothy Vickers | Efficient reduction of target RNA's by single-and double-stranded oligomeric compounds |
| EP1658304A4 (en) * | 2002-09-28 | 2009-01-14 | Massachusetts Inst Technology | THERAPY ANTIGRIPPALE |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| US20040242518A1 (en) * | 2002-09-28 | 2004-12-02 | Massachusetts Institute Of Technology | Influenza therapeutic |
| US9486070B2 (en) | 2012-10-10 | 2016-11-08 | Stirworks Inc. | Height-adjustable support surface and system for encouraging human movement and promoting wellness |
-
2006
- 2006-04-07 KR KR1020077025995A patent/KR20070118703A/ko not_active Withdrawn
- 2006-04-07 AU AU2006235364A patent/AU2006235364A1/en not_active Abandoned
- 2006-04-07 CA CA002603842A patent/CA2603842A1/en not_active Abandoned
- 2006-04-07 EP EP06749684A patent/EP1874802A2/en not_active Withdrawn
- 2006-04-07 NZ NZ563845A patent/NZ563845A/xx not_active IP Right Cessation
- 2006-04-07 US US11/910,971 patent/US20100254945A1/en not_active Abandoned
- 2006-04-07 JP JP2008505634A patent/JP2008535496A/ja active Pending
- 2006-04-07 CN CNA2006800114415A patent/CN101184839A/zh active Pending
- 2006-04-07 WO PCT/US2006/013374 patent/WO2006110688A2/en not_active Ceased
-
2007
- 2007-11-06 NO NO20075655A patent/NO20075655L/no not_active Application Discontinuation
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