JP2008503569A5 - - Google Patents
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- Publication number
- JP2008503569A5 JP2008503569A5 JP2007517982A JP2007517982A JP2008503569A5 JP 2008503569 A5 JP2008503569 A5 JP 2008503569A5 JP 2007517982 A JP2007517982 A JP 2007517982A JP 2007517982 A JP2007517982 A JP 2007517982A JP 2008503569 A5 JP2008503569 A5 JP 2008503569A5
- Authority
- JP
- Japan
- Prior art keywords
- lpl
- gene therapy
- seq
- drug
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 238000001415 gene therapy Methods 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 239000013603 viral vector Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58090304P | 2004-06-21 | 2004-06-21 | |
| PCT/NL2005/000446 WO2005123117A1 (en) | 2004-06-21 | 2005-06-20 | Treatment of non alcoholic steatotic hepatitis (nash) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008503569A JP2008503569A (ja) | 2008-02-07 |
| JP2008503569A5 true JP2008503569A5 (enExample) | 2008-07-31 |
Family
ID=34970452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007517982A Pending JP2008503569A (ja) | 2004-06-21 | 2005-06-20 | 非アルコール性脂肪性肝炎（ｎａｓｈ）の治療 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20080280823A1 (enExample) |
| EP (1) | EP1761273B1 (enExample) |
| JP (1) | JP2008503569A (enExample) |
| KR (1) | KR20070057712A (enExample) |
| CN (1) | CN1972709A (enExample) |
| AT (1) | ATE395073T1 (enExample) |
| AU (1) | AU2005253897B2 (enExample) |
| CA (1) | CA2568643A1 (enExample) |
| CY (1) | CY1108552T1 (enExample) |
| DE (1) | DE602005006809D1 (enExample) |
| DK (1) | DK1761273T3 (enExample) |
| ES (1) | ES2306163T3 (enExample) |
| PL (1) | PL1761273T3 (enExample) |
| PT (1) | PT1761273E (enExample) |
| SI (1) | SI1761273T1 (enExample) |
| WO (1) | WO2005123117A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523330A (ja) | 2000-02-04 | 2003-08-05 | チルドレンズ・ホスピタル・リサーチ・ファウンデイション | アテローム性動脈硬化症および関連疾患のための脂質加水分解治療 |
| US20090297496A1 (en) * | 2005-09-08 | 2009-12-03 | Childrens Hospital Medical Center | Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases |
| WO2010134806A1 (en) * | 2009-05-18 | 2010-11-25 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Use of lipoprotein lipase (lpl) in therapy |
| CN102628060A (zh) * | 2012-03-22 | 2012-08-08 | 北京济福霖生物技术有限公司 | 一种低脂奶的生产方法 |
| MA41035A (fr) * | 2014-08-19 | 2017-08-15 | Shire Human Genetic Therapies | Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë |
| CN115109788A (zh) * | 2021-03-23 | 2022-09-27 | 北京锦篮基因科技有限公司 | Aav介导的人脂蛋白脂酶肝脏异位表达载体及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5799200A (en) * | 1999-06-24 | 2001-01-31 | Academic Hospital At The University Of Amsterdam | Lpl variant therapeutics |
| FR2795832B1 (fr) * | 1999-06-30 | 2004-06-18 | Plastic Omnium Valeo Interiors | Dispositif de commande d'actionneur notamment pour vehicule |
| AU6814901A (en) * | 2000-06-01 | 2001-12-11 | Univ North Carolina | Methods and compounds for controlled release of recombinant parvovirus vectors |
-
2005
- 2005-06-20 CA CA 2568643 patent/CA2568643A1/en not_active Abandoned
- 2005-06-20 WO PCT/NL2005/000446 patent/WO2005123117A1/en not_active Ceased
- 2005-06-20 PL PL05753069T patent/PL1761273T3/pl unknown
- 2005-06-20 KR KR1020067027008A patent/KR20070057712A/ko not_active Ceased
- 2005-06-20 US US11/570,917 patent/US20080280823A1/en not_active Abandoned
- 2005-06-20 SI SI200530350T patent/SI1761273T1/sl unknown
- 2005-06-20 DE DE200560006809 patent/DE602005006809D1/de not_active Expired - Lifetime
- 2005-06-20 CN CNA2005800206338A patent/CN1972709A/zh active Pending
- 2005-06-20 EP EP20050753069 patent/EP1761273B1/en not_active Expired - Lifetime
- 2005-06-20 ES ES05753069T patent/ES2306163T3/es not_active Expired - Lifetime
- 2005-06-20 PT PT05753069T patent/PT1761273E/pt unknown
- 2005-06-20 JP JP2007517982A patent/JP2008503569A/ja active Pending
- 2005-06-20 AT AT05753069T patent/ATE395073T1/de active
- 2005-06-20 AU AU2005253897A patent/AU2005253897B2/en not_active Ceased
- 2005-06-20 DK DK05753069T patent/DK1761273T3/da active
-
2008
- 2008-08-11 CY CY20081100842T patent/CY1108552T1/el unknown
-
2010
- 2010-12-03 US US12/960,081 patent/US20110081332A1/en not_active Abandoned