JP2008535496A - 呼吸器ウィルス感染用ＲＮＡｉ治療因子 - Google Patents

呼吸器ウィルス感染用ＲＮＡｉ治療因子 Download PDF

Info

Publication number
JP2008535496A
JP2008535496A JP2008505634A JP2008505634A JP2008535496A JP 2008535496 A JP2008535496 A JP 2008535496A JP 2008505634 A JP2008505634 A JP 2008505634A JP 2008505634 A JP2008505634 A JP 2008505634A JP 2008535496 A JP2008535496 A JP 2008535496A
Authority
JP
Japan
Prior art keywords
sirna
virus
nucleic acid
rnai
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008505634A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008535496A5 (enExample
Inventor
ガ，チン
クマル，ムケシュ
マックスウィゲン，ジェイムズ，アンソニー
Original Assignee
ナステック ファーマスーティカル カンパニー インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ナステック ファーマスーティカル カンパニー インク． filed Critical ナステック ファーマスーティカル カンパニー インク．
Publication of JP2008535496A publication Critical patent/JP2008535496A/ja
Publication of JP2008535496A5 publication Critical patent/JP2008535496A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2008505634A 2005-04-08 2006-04-07 呼吸器ウィルス感染用ＲＮＡｉ治療因子 Pending JP2008535496A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66994205P 2005-04-08 2005-04-08
PCT/US2006/013374 WO2006110688A2 (en) 2005-04-08 2006-04-07 Rnai therapeutic for respiratory virus infection

Publications (2)

Publication Number Publication Date
JP2008535496A true JP2008535496A (ja) 2008-09-04
JP2008535496A5 JP2008535496A5 (enExample) 2009-05-28

Family

ID=37087607

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008505634A Pending JP2008535496A (ja) 2005-04-08 2006-04-07 呼吸器ウィルス感染用ＲＮＡｉ治療因子

Country Status (10)

Country Link
US (1) US20100254945A1 (enExample)
EP (1) EP1874802A2 (enExample)
JP (1) JP2008535496A (enExample)
KR (1) KR20070118703A (enExample)
CN (1) CN101184839A (enExample)
AU (1) AU2006235364A1 (enExample)
CA (1) CA2603842A1 (enExample)
NO (1) NO20075655L (enExample)
NZ (1) NZ563845A (enExample)
WO (1) WO2006110688A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015518721A (ja) * 2012-05-22 2015-07-06 オリックス ファーマシューティカルズ インコーポレイテッドＯｌｉｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途
US10214744B2 (en) 2010-10-22 2019-02-26 Sungkyunkwan University Foundation For Corporate Collaboration Nucleic acid molecules inducing RNA interference, and uses thereof

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006085987A2 (en) 2004-07-09 2006-08-17 University Of Iowa Research Foundation Rna interference in respiratory epitheial cells
CA2602797A1 (en) * 2005-03-31 2007-02-15 Ronen Kahana Creating poultry and other animals resistant to viral disease
EP2125024B1 (en) 2007-03-23 2013-02-13 TO-BBB Holding B.V. Targeted intracellular delivery of antiviral agents
EP2146575A4 (en) * 2007-04-12 2010-11-24 Alnylam Pharmaceuticals Inc INFLUENZA POLYNUCLEOTIDES, EXPRESSION CONSTRUCTS, COMPOSITIONS AND METHOD FOR THEIR USE
JP2010527914A (ja) * 2007-04-26 2010-08-19 クォーク ファーマシューティカルズ インコーポレーティッド 呼吸器系への抑制性核酸分子の治療的送達
AU2008251037A1 (en) * 2007-05-15 2008-11-20 Johnson & Johnson Research Pty Limited Suppression of viruses involved in respiratory infection or disease
EP2527445A3 (en) * 2007-05-16 2013-02-20 MAT Malta Advanced Technologies Limited Treatment and prevention of influenza
US20100273156A1 (en) * 2007-05-31 2010-10-28 Becton, Dickinson And Company Sequences and methods for detecting influenza a and influenza b virus
KR101605932B1 (ko) 2009-12-18 2016-03-24 노파르티스 아게 Ｈｓｆ1-관련 질환을 치료하기 위한 유기 조성물
KR20140027211A (ko) 2011-04-04 2014-03-06 유니버시티 오브 아이오와 리써치 파운데이션 백신 면역원성의 개선 방법
US9328347B2 (en) 2011-07-18 2016-05-03 Oregon Health & Science University siRNA useful in the treatment of flavivirus infection
CN103930547A (zh) 2011-09-02 2014-07-16 诺华股份有限公司 用于治疗hsf1相关疾病的有机组合物
WO2013103434A1 (en) * 2011-10-19 2013-07-11 Harrisvaccines, Inc. Methods and compositions to protect aquatic invertebrates from disease
CN103966212A (zh) * 2013-02-06 2014-08-06 霍晋 A型流感病毒NP基因有干扰作用的siRNA序列的设计及应用
WO2014138792A1 (en) * 2013-03-14 2014-09-18 Commonwealth Scientific And Industrial Research Organisation Double-stranded rna
WO2017085550A1 (en) 2015-11-16 2017-05-26 Olix Pharmaceuticals, Inc. Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3
CN108779464B (zh) 2016-02-02 2022-05-17 奥利克斯医药有限公司 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病
US10358648B2 (en) 2016-02-02 2019-07-23 Olix Pharmaceuticals, Inc. Treatment of atopic dermatitis and asthma using RNA complexes that target IL4Rα, TRPA1, or F2RL1
US11339392B2 (en) 2016-03-02 2022-05-24 The Board Of Trustees Of The Leland Stanford Junior University Pan-genotypic agents against influenza virus and methods of using the same
EP3423107A4 (en) * 2016-03-02 2020-01-15 The Board of Trustees of the Leland Stanford Junior University PAN-GENOTYPICAL AGENTS AGAINST INFLUENZA-B VIRUS AND METHOD FOR USE THEREOF
WO2021201996A1 (en) * 2020-02-14 2021-10-07 The Board Of Trustees Of The Leland Stanford Junior University Pan-genotypic agents against respiratory viruses and methods of using the same
KR102339886B1 (ko) 2016-04-11 2021-12-17 올릭스 주식회사 연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
WO2018146557A2 (en) 2017-02-10 2018-08-16 Dong Ki Lee Long double-stranded rna for rna interference
US11952631B2 (en) * 2017-10-09 2024-04-09 Medizinische Hochschule Hannover Diagnostics and therapy for human respiratory syncytial virus
US11739350B2 (en) 2018-04-10 2023-08-29 Ottawa Hospital Research Institute MicroRNA-based compositions and methods used in disease treatment
US11702709B2 (en) * 2021-02-09 2023-07-18 Pathogendx, Inc. Combinatorial microarray assay for clade variant detection
CN115120608A (zh) * 2021-03-26 2022-09-30 圣诺生物医药技术(苏州)有限公司 一种siRNA药物、药物组合物、siRNA-小分子药物偶联物及其应用
EP4562157A1 (en) * 2022-07-28 2025-06-04 New York University Targeting long non-coding rna chromr in interferon-mediated inflammation in humans
EP4527927A1 (en) 2023-09-22 2025-03-26 Medizinische Hochschule Hannover Oligonucleotide-based strategies to combat respiratory viruses
CN118800477B (zh) * 2024-07-11 2025-05-02 中国人民解放军军事科学院军事医学研究院 禽源性流感病毒溢出风险评估方法、设备、介质及产品

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001124775A (ja) * 1999-08-31 2001-05-11 Becton Dickinson & Co インフルエンザａ型およびｂ型の存在を視覚的に検出するためのフロースルーアッセイ
WO2004028471A2 (en) * 2002-09-28 2004-04-08 Massachusetts Institute Of Technology Influenza therapeutic

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US4876187A (en) * 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5573907A (en) 1990-01-26 1996-11-12 Abbott Laboratories Detecting and amplifying target nucleic acids using exonucleolytic activity
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
WO1995014106A2 (en) * 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
ATE247716T1 (de) 1994-02-07 2003-09-15 Beckman Coulter Inc Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse
JP3898228B2 (ja) * 1996-04-12 2007-03-28 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク 検出プローブ、キット及びアッセイ
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US20030087851A1 (en) * 1999-01-20 2003-05-08 Biozak, Inc. Pharmaceutical composition for treating or preventing influenza, and novel oligonucleotide
US6277607B1 (en) * 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
US20040137471A1 (en) * 2002-09-18 2004-07-15 Timothy Vickers Efficient reduction of target RNA's by single-and double-stranded oligomeric compounds
US20060160759A1 (en) * 2002-09-28 2006-07-20 Jianzhu Chen Influenza therapeutic
US20040242518A1 (en) * 2002-09-28 2004-12-02 Massachusetts Institute Of Technology Influenza therapeutic
US9486070B2 (en) 2012-10-10 2016-11-08 Stirworks Inc. Height-adjustable support surface and system for encouraging human movement and promoting wellness

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001124775A (ja) * 1999-08-31 2001-05-11 Becton Dickinson & Co インフルエンザａ型およびｂ型の存在を視覚的に検出するためのフロースルーアッセイ
WO2004028471A2 (en) * 2002-09-28 2004-04-08 Massachusetts Institute Of Technology Influenza therapeutic

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10214744B2 (en) 2010-10-22 2019-02-26 Sungkyunkwan University Foundation For Corporate Collaboration Nucleic acid molecules inducing RNA interference, and uses thereof
US10829760B2 (en) 2010-10-22 2020-11-10 Olix Pharmaceuticals, Inc. Nucleic acid molecules inducing RNA interference, and uses thereof
JP2015518721A (ja) * 2012-05-22 2015-07-06 オリックス ファーマシューティカルズ インコーポレイテッドＯｌｉｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途
JP2017093448A (ja) * 2012-05-22 2017-06-01 オリックス ファーマシューティカルズ インコーポレイテッドＯｌｉｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途
US10125362B2 (en) 2012-05-22 2018-11-13 Olix Pharmaceuticals, Inc. RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor
JP2019122379A (ja) * 2012-05-22 2019-07-25 オリックス ファーマシューティカルズ インコーポレイテッドＯｌｉｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途
US10883105B2 (en) 2012-05-22 2021-01-05 Olix Pharmaceuticals, Inc. RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor
JP6999590B2 (ja) 2012-05-22 2022-01-18 オリックス ファーマシューティカルズ インコーポレイテッド 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途

Also Published As

Publication number Publication date
CA2603842A1 (en) 2006-10-19
KR20070118703A (ko) 2007-12-17
CN101184839A (zh) 2008-05-21
WO2006110688A2 (en) 2006-10-19
EP1874802A2 (en) 2008-01-09
WO2006110688A3 (en) 2008-01-10
NZ563845A (en) 2010-09-30
WO2006110688A9 (en) 2007-03-15
AU2006235364A1 (en) 2006-10-19
NO20075655L (no) 2007-11-13
US20100254945A1 (en) 2010-10-07

Similar Documents

Publication Publication Date Title
JP2008535496A (ja) 呼吸器ウィルス感染用ＲＮＡｉ治療因子
US20100144843A1 (en) Rnai therapeutic for respiratory virus infection
US20060160759A1 (en) Influenza therapeutic
US8691781B2 (en) Compositions for treating respiratory viral infections and their use
WO2023030246A1 (zh) 一种用于治疗或预防非洲猪瘟的重组prrsv及其药物组合物
US10219492B2 (en) Compounds and methods for altering RSV replication rate
US20090042823A1 (en) Uses of broad spectrum rnai therapeutics against influenza
Deffrasnes et al. Inhibition of human metapneumovirus replication by small interfering RNA
CN101880677B (zh) 针对2009新甲型流感病毒多聚酶基因和核蛋白基因的siRNA序列及其应用
Xu et al. Potent inhibition of respiratory syncytial virus by combination treatment with 2–5A antisense and ribavirin
Ferreira et al. Inhibition of avian metapneumovirus (AMPV) replication by RNA interference targeting nucleoprotein gene (N) in cultured cells
JP2008533990A (ja) インフルエンザ治療剤
Bohle et al. Species specific inhibition of viral replication using dicer substrate siRNAs (DsiRNAs) targeting the viral nucleoprotein of the fish pathogenic rhabdovirus viral hemorrhagic septicemia virus (VHSV)
WO2021228585A1 (en) Sina molecules, methods of production and uses thereof
US20070203082A1 (en) RNAI Agents For Anti-SARS Coronavirus Therapy
Bitko et al. Respiratory viral diseases: access to RNA interference therapy
HK1121182A (en) Rnai therapeutic for respiratory virus infection
CN100365122C (zh) 针对乙型流感病毒多聚酶基因的siRNA序列及其应用
US20210332364A1 (en) siNA MOLECULES, METHODS OF PRODUCTION AND USES THEREOF
Uhl Cellular Conflicts Between RNA Virus and Host Biology
US20100286238A1 (en) Suppression of viruses involved in respiratory infection or disease
Wang Development of RNA-based molecules for the inhibition of influenza A virus
CN102618541A (zh) 用于治疗呼吸道病毒感染的组合物及其用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090407

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090407

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100331

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110802

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120117